High Drug Payload 10-Hydroxycamptothecin Nanosuspensions Stabilized by Cholesterol-PEG: &lt;I&gt;In Vitro&lt;/I&gt; and &lt;I&gt;In Vivo&lt;/I&gt; Investigation

Yang, Linjie; Jiang, Jizong; Hong, Jingyi; Jiang, Di; Kuang, Hai‐Xue; Wang, Xiangtao

doi:10.1166/jbn.2015.2050

Cited by 13 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some cases, temperature of antisolvent precipitation influences the particle size and stability of the obtained nanorods (Yang et al., 2015 ), so different temperatures (15 °C, 25 °C, 35 °C and 45 °C) were tested to prepare HICT-NRs at the same HICT/TPGS feeding ratio of 1:1. It turned out that 25 °C was the most proper temperature and the obtained HICT-NRs had the smallest particle size (202 nm), the narrowest size distribution (PDI value, 0.17) and the highest zeta potential (-22.9 mV) ( Supplementary Table S3 ).…”

Section: Resultsmentioning

confidence: 99%

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

et al. 2020

Drug Delivery

Self Cite

View full text Add to dashboard Cite

Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro and in vivo antitumor effects. Nanorods (NRs) were prepared for ICT and HICT by anti-solvent precipitation method using D-alpha tocopherol acid polyethylene glycol succinate (TPGS) as a stabilizer. The prepared ICT-NRs and HICT-NRs had similar diameter (155.5 nm and 201.7 nm), high drug loading content (43.30 ± 0.22% and 41.08 ± 0.19%), excellent stability and a similar sustaining drug release manner. Nanorods improved the in vitro toxicity against 4 different cancer cells in contrast to free ICT or free HICT; however, no significant difference was observed in this regard between ICT-NRs and HICT NRs. In the in vivo study on the anticancer efficacy on MCF-7 and PLC/PRE/5 tumor-bearing mice model, HICR-NRs displayed certain advantage over ICT NRs with higher tumor inhibition rate.

show abstract

Section: Resultsmentioning

confidence: 99%

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

et al. 2020

Drug Delivery

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our previous study, 29 we found that 10-HCPT nanosuspensions were not very stable in normal saline, but were stable in 5% glucose and plasma; therefore, the nanocrystals could be intravenously injected into the tail vein of rats for the pharmacokinetics study.…”

Section: Pharmacokinetic Analysismentioning

confidence: 97%

A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation

Yang¹,

Liu²,

Zhao³

et al. 2016

IJN

Self Cite

View full text Add to dashboard Cite

10-Hydroxycamptothecin (10-HCPT) is a promising anticancer drug with a wide spectrum of antitumor activities. Due to its poor solubility, the carboxylate form that shows high water solubility but minimal anticancer activity and pharmacokinetic defects is used in the marketed 10-HCPT injections, resulting in its limited clinical application. To develop a simple, safe, and highly effective drug delivery system, a modified acid–base microprecipitation combined with a high-pressure homogenization technique was adopted to prepare 10-HCPT nanocrystals. Neither organic solvents nor stabilizers were employed throughout the preparation process. The in vitro and in vivo performances of the resulting10-HCPT nanocrystals were investigated systematically. The nanocrystals were spherical with a small size of ~130 nm, and the actual drug-loading content was as high as 75%. The nanocrystals displayed a sustained release pattern and were proven to have a higher cell uptake and antiproliferative activity than the 10-HCPT injections. The 10-HCPT nanocrystals also showed enhanced drug accumulation in tumors and better anticancer efficacy in 4T1-bearing mice. In summary, the 10-HCPT nanocrystals prepared in this study seem to be a promising delivery system for a new form of 10-HCPT dosages.

show abstract

“…30 In the preparation method, the dropwise method was selected but not the jet stream because our preliminary experiment demonstrated that the jet stream method would lead to a large particle size with a large PDI value or precipitation due to nonuniform nucleus formation and fast crystal growth. The slow speed of the dropwise method could guarantee sufficient drug supersaturation and uniform nucleus formation.…”

Section: Technique Process Optimizationmentioning

confidence: 99%

Annonaceous acetogenins nanosuspensions stabilized by PCL–PEG block polymer: significantly improved antitumor efficacy

Hong

Li²,

et al. 2016

IJN

Self Cite

View full text Add to dashboard Cite

Annonaceous acetogenins (ACGs) have shown superior antitumor activity against a variety of cancer cell lines, but their clinical application has been limited by their poor solubility. In this study, ACGs-nanosuspensions (NSps) were successfully prepared by a precipitation ultrasonic method using monomethoxypoly (ethylene glycol)2000–poly (ε-caprolactone)2000 (mPEG2000–PCL2000) as a stabilizer. The resultant ACGs-NSps had a mean particle size of 123.2 nm, a zeta potential of −20.17 mV, and a high drug payload of 73.68%. ACGs-NSps were quite stable in various physiological solutions, and they exhibited sustained drug release. Compared to free drug, ACGs-NSps exhibited stronger cytotoxicity against 4T1, MCF-7, and HeLa cells. An in vivo real-time biodistribution investigation after labeling with 1,1′-dioctadecyltetramethyl indotricarbocyanine iodide, a noninvasive near-infrared fluorescence probe, demonstrated that ACGs-NSps could effectively accumulate in tumor. An in vivo antitumor activity study in 4T1 tumor-bearing mice revealed that ACGs-NSps achieved much better therapeutic efficacy than the traditional dosage form (oil solution) even at 1/10 of the dose (74.83% vs 45.53%, P <0.05), demonstrating that NSp was a good dosage form for ACGs to treat cancer.

show abstract

High Drug Payload 10-Hydroxycamptothecin Nanosuspensions Stabilized by Cholesterol-PEG: <I>In Vitro</I> and <I>In Vivo</I> Investigation

Cited by 13 publications

References 0 publications

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation

Annonaceous acetogenins nanosuspensions stabilized by PCL–PEG block polymer: significantly improved antitumor efficacy

Contact Info

Product

Resources

About

High Drug Payload 10-Hydroxycamptothecin Nanosuspensions Stabilized by Cholesterol-PEG: <I>In Vitro</I> and <I>In Vivo</I> Investigation

Cited by 13 publications

References 0 publications

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods

A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation

Annonaceous acetogenins nanosuspensions stabilized by PCL&ndash;PEG block polymer: significantly improved antitumor efficacy

Contact Info

Product

Resources

About

Annonaceous acetogenins nanosuspensions stabilized by PCL–PEG block polymer: significantly improved antitumor efficacy