High energy X-ray scattering tomography applied to bone

Stock, Stuart R.; Carlo, Francesco De; Almer, Jonathan

doi:10.1016/j.jsb.2007.10.001

Cited by 82 publications

(54 citation statements)

References 41 publications

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“…Unfortunately, the restriction to random orientation or fiber symmetry of the scattering particles limits this technique to rather simple cases which are usually not given in hierarchical biological tissues. A similar approach has recently also been reported for WAXS on a bone specimen using selected HAP reflections, 112 although no comprehen- Scanning texture analysis in human osteons using a 1 m x-ray beam at the microfocus beamline ID13 ͑ESRF, Grenoble͒. ͑a͒ shows the geometry used for the measurements.…”

Section: Fb23 Oskar Paris: From Diffraction To Imaging Fb23mentioning

confidence: 98%

From diffraction to imaging: New avenues in studying hierarchical biological tissues with x-ray microbeams (Review)

Paris

2008

Biointerphases

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Load bearing biological materials such as bone or arthropod cuticle have optimized mechanical properties which are due to their hierarchical structure ranging from the atomic/molecular level up to macroscopic length scales. Structural investigations of such materials require new experimental techniques with position resolution ideally covering several length scales. Beside light and electron microscopy, synchrotron radiation based x-ray imaging techniques offer excellent possibilities in this respect, ranging from full field imaging with absorption or phase contrast to x-ray microbeam scanning techniques. A particularly useful approach for the study of biological tissues is the combination x-ray microbeam scanning with nanostructural information obtained from x-ray scattering [small-angle x-ray scattering (SAXS) and wide-angle x-ray scattering (WAXS)]. This combination allows constructing quantitative images of nanostructural parameters with micrometer scanning resolution, and hence, covers two length scales at once. The present article reviews recent scanning microbeam SAXS/WAXS work on bone and some other biological tissues with particular emphasis on the imaging capability of the method. The current status of instrumentation and experimental possibilities is also discussed, and a short outlook about actual and desirable future developments in the field is given.

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Section: Fb23 Oskar Paris: From Diffraction To Imaging Fb23mentioning

confidence: 98%

From diffraction to imaging: New avenues in studying hierarchical biological tissues with x-ray microbeams (Review)

Paris

2008

Biointerphases

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“…However, such approaches assume isotropic azimuthal scattering, ignoring the anisotropy in the diffraction patterns. Approaches that take into account the structural anisotropy have also been proposed [158][159][160], where diffraction information is reconstructed for different azimuthal angles. These studies provide tissue anisotropy information in a tomographic way.…”

Section: X-ray Scattering/diffraction Tensor Tomographymentioning

confidence: 99%

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

Georgiadis

Müller

Schneider

2016

J. R. Soc. Interface.

114

100

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Bone's remarkable mechanical properties are a result of its hierarchical structure. The mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's building blocks at an ultrastructural level. The organization of bone's ultrastructure with respect to the orientation and arrangement of mineralized collagen fibrils has been the matter of numerous studies based on a variety of imaging techniques in the past decades. These techniques either exploit physical principles, such as polarization, diffraction or scattering to examine bone ultrastructure orientation and arrangement, or directly image the fibrils at the sub-micrometre scale. They make use of diverse probes such as visible light, X-rays and electrons at different scales, from centimetres down to nanometres. They allow imaging of bone sections or surfaces in two dimensions or investigating bone tissue truly in three dimensions, in vivo or ex vivo, and sometimes in combination with in situ mechanical experiments. The purpose of this review is to summarize and discuss this broad range of imaging techniques and the different modalities of their use, in order to discuss their advantages and limitations for the assessment of bone ultrastructure organization with respect to the orientation and arrangement of mineralized collagen fibrils.

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“…Microcracking should be correlated directly with dropping internal strains. The X-ray scattering tomography (Stock et al, 2008a) might be applied to teeth and extended to 3D strain mapping of the DEJ vicinity.…”

Section: Possible Future Research Directionsmentioning

confidence: 99%

High energy X-ray scattering quantification of in situ-loading-related strain gradients spanning the dentinoenamel junction (DEJ) in bovine tooth specimens

Almer

Stock

2010

Journal of Biomechanics

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High energy X-ray scattering tomography applied to bone

Cited by 82 publications

References 41 publications

From diffraction to imaging: New avenues in studying hierarchical biological tissues with x-ray microbeams (Review)

From diffraction to imaging: New avenues in studying hierarchical biological tissues with x-ray microbeams (Review)

Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils

High energy X-ray scattering quantification of in situ-loading-related strain gradients spanning the dentinoenamel junction (DEJ) in bovine tooth specimens

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