High expression of CD8 predicts favorable prognosis in patients with lung adenocarcinoma

Abstract

Lung carcinoma is the most common cause of malignant death worldwide. CD8+ T cells, as critical elements in antitumor immunity, could function as good prognostic indicators in various kinds of cancers such as renal cell carcinoma and colorectal cancer, but its prognostic role in lung adenocarcinoma is still unclear. The objective of this study was to explore the prognostic role of CD8 expression in lung adenocarcinoma.Paired tumor and adjacent noncancerous tissues were obtained from 102 patients with lung adenocarcinoma, and CD8 expression of these samples was examined by immunohistochemistry. We evaluated the relationships between the expression of CD8 and pathological grade, TNM stage, clinical stage, as well as overall survival (OS).Expression of CD8 was significantly increased in lung adenocarcinoma compared with that in adjacent lung adenocarcinoma (P < .001). CD8 expression was negatively correlated with pathological grade (r = –0.216, P = .022) and N stage (r = –0.372, P < .001), while no statistical correlation with T stage, or clinical stage. Importantly, OS was numerically increased in patients with high expression of CD8 than the group of intermediate and low CD8 expression (P = .12). Furthermore, CD8 could significantly increase OS (P = .043, HR: .713, 95%CI: .515–.989) by univariate Cox's proportional hazards regression analysis.Our data indicated that expression of CD8, as a protective factor, is correlated with the outcome of patients with lung adenocarcinoma. Furthermore, CD8 might be a novel prognostic biological marker for patients with lung adenocarcinoma.

Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis

“…Twenty-three studies underwent pooled analysis ( Supplementary Table 1 , Supplementary Figure 1H ) [ 23 , 24 , 29 , 31 , 32 , 60 – 64 , 66 – 78 ]. Although CD8+ T cells in the general compartment was not associated with OS (HR 0.80; 0.56–1.15) or DFS (HR 0.70; 0.48–1.02), when analysed according to tumor or stroma compartment, the prognostic value of CD8+ T cells could be appreciated (Table 1 , Figure 3C ).…”

Prognostic value of VISTA in solid tumours: a systematic review and meta-analysis

“…Recently, an increasing number of researchers [21][22][23][24][25][26][27][28][29] have paid great attention to the CD8 (+) TILs in the tumour microenvironment due to their anti-tumour effect. Gabrielson's research 21 illustrated that high numbers of CD8 (+) TILs significantly correlated with a low rate of recurrence and prolonged relapse-free survival in patients with HCC.…”

“…Goode 22 showed that in high-grade serous ovarian cancer, high numbers of CD8 (+) TILs were significantly associated with improved OS. Ye 28 found that high numbers of CD8 (+) TILs predicted favourable prognosis in lung adenocarcinoma patients. These studies may indicate that CD8 (+) TILs are a prognostic biomarker that correlates with a favourable prognosis in solid tumours.…”

AKIP1 expression in tumor tissue as a new biomarker for disease monitoring and prognosis in non‐small cell lung cancer: Results of a retrospective study

“…According to IHC staining, the expression of AKIP1 in the tumor and paired adjacent tissues was assessed by a semiquantitative scoring method based on the average intensity and percentage of positively stained tumor cells. 12 The score of intensity was assessed as follows: 0 (no staining), 1 (weak staining), 2 (moderate staining), and 3 (strong staining). The percentage of positively stained tumor cells was scored according to the following standard: 0, 0%; 1, <25%; 2, 26 ~ 50%; 3, 51 ~ 75%; and 4, >75%.…”