High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma

Lyu, Shanshan; Lu, Jiabin; Chen, Wendan; Huang, Weiye; Huang, Haoqi; Xi, Shaoyan; Yan, Shumei

doi:10.3892/ol.2020.12038

Cited by 8 publications

(6 citation statements)

References 32 publications

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“…In esophageal squamous cell carcinoma, eIF4A2 has been found to be more highly expressed in neoplastic tissues than in normal tissues, and patients with high expression levels of eIF4A2 tend to have a poorer prognosis (Lyu et al, 2020). Furthermore, the univariate and multivariate analyses have suggested that eIF4A2 is an independent prognostic factor in esophageal squamous cell carcinoma (Lyu et al, 2020).…”

Section: Expression Patterns Of Eif4a1 and Eif4a2 In Breast Cancermentioning

confidence: 99%

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Xue

et al. 2021

Front. Cell Dev. Biol.

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The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases. In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different translation stages (initiation, mRNA localization, export, and mRNA splicing). These proteins also frequently served as targets of microRNAs (miRNAs) or long noncoding RNAs (lncRNAs) to mediate epithelial-mesenchymal transition (EMT), which was associated with tumor cell invasion and metastasis. To define the differential expression of eIF4A family members, we applied the Tumor Immune Estimation Resource website. We figured out that the eIF4A family genes were differently expressed in specific cancer types. We also found that the level of the eIF4A family genes were associated with abundant immune cells infiltration and tumor purity. The associations between eIF4A proteins and cancer patient clinicopathological features suggested that eIF4A proteins might serve as biomarkers for early tumor diagnosis, histological classification, and clinical grading/staging, providing new tools for precise and individualized cancer treatment.

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Section: Expression Patterns Of Eif4a1 and Eif4a2 In Breast Cancermentioning

confidence: 99%

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Xue

et al. 2021

Front. Cell Dev. Biol.

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“…Since the majority of studies support the involvement of p-eIF4E in cancer progression, future studies should investigate the effects of AA on the phosphorylation status of this protein. Recently, high levels of eIF4A2 were associated with poor prognosis in esophageal squamous cell carcinoma [64].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Investigation of the Effect of Dietary Acrylamide and Evaluation of Its Clinical Relevance in Colon Cancer

Neophytou,

Katsonouri,

Christodoulou

et al. 2023

Toxics

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Dietary exposure to acrylamide (AA) has been linked with carcinogenicity in the gastrointestinal (GI) tract. However, epidemiologic data on AA intake in relation to cancer risk are limited and contradictory, while the potential cancer-inducing molecular pathways following AA exposure remain elusive. In this study, we collected mechanistic information regarding the induction of carcinogenesis by dietary AA in the colon, using an established animal model. Male Balb/c mice received AA orally (0.1 mg/kg/day) daily for 4 weeks. RNA was extracted from colon tissue samples, followed by RNA sequencing. Comparative transcriptomic analysis between AA and mock-treated groups revealed a set of differentially expressed genes (DEGs) that were further processed using different databases through the STRING-DB portal, to reveal deregulated protein–protein interaction networks. We found that genes implicated in RNA metabolism, processing and formation of the ribosomal subunits and protein translation and metabolism are upregulated in AA-exposed colon tissue; these genes were also overexpressed in human colon adenocarcinoma samples and were negatively correlated with patient overall survival (OS), based on publicly available datasets. Further investigation of the potential role of these genes during the early stages of colon carcinogenesis may shed light into the underlying mechanisms induced by dietary AA exposure.

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“…The two are largely redundant and will be interchangeably referred to as DDX2, although there is emerging evidence of different functions in vivo [306] , [307] . A specific role of DDX2B in esophageal squamous cell carcinoma was recently reported [308] . DDX2 upregulation drives translation reprogramming in pancreatic [309] , [310] , breast [311] , [312] and other cancers [302] , [313] , [314] , [315] .…”

Section: Introductionmentioning

confidence: 95%

Action and function of helicases on RNA G-quadruplexes

Caterino

Paeschke

2022

Methods

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High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma

Cited by 8 publications

References 32 publications

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers

In Vivo Investigation of the Effect of Dietary Acrylamide and Evaluation of Its Clinical Relevance in Colon Cancer

Action and function of helicases on RNA G-quadruplexes

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