High Expression of Macrophage Migration Inhibitory Factor in the Synovial Tissues of Rheumatoid Joints

Onodera, Shin; Tanji, Hiroshi; Suzuki, Kouji; Kaneda, Kiyoshi; Mizue, Yuka; Sagawa, Akira; Nishihira, Jun

doi:10.1006/cyto.1998.0402

Cited by 91 publications

(56 citation statements)

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“…Indeed, we found that MIF content in synovial fluids of RA patients was significantly higher (85.7 Ϯ 35.2 ng/ml, mean Ϯ S.D.) than in those of OA patients (19.5 Ϯ 5.3 ng/ml) and normal controls (10.4 Ϯ 1.1 ng/ml) (28). It is conceivable that MIF, particularly in RA, plays an important role in tissue destruction of rheumatoid joints.…”

Section: Figmentioning

confidence: 77%

Macrophage Migration Inhibitory Factor Up-regulates Expression of Matrix Metalloproteinases in Synovial Fibroblasts of Rheumatoid Arthritis

Onodera¹,

Kaneda²,

Mizue³

et al. 2000

Journal of Biological Chemistry

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205

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Section: Figmentioning

confidence: 77%

Macrophage Migration Inhibitory Factor Up-regulates Expression of Matrix Metalloproteinases in Synovial Fibroblasts of Rheumatoid Arthritis

Onodera¹,

Kaneda²,

Mizue³

et al. 2000

Journal of Biological Chemistry

Self Cite

236

205

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“…6 MIF was originally described over 30 years ago as a Tlymphocyte-derived factor that inhibited the migration of peritoneal macrophages, 7 but it is now known that several other cell types, including macrophages themselves, are important sources of MIF. 8 MIF levels are elevated in the serum and synovial fluid of patients with rhemuatoid arthritis, 2,9 and within the synovial joint MIF immunostaining can be localized to the synovial lining CD14 + macrophages and fibroblast-like synoviocytes. 2 Upon release MIF is directly pro-inflammatory by activating or promoting cytokine expression (TNF␣, 8,10 IL-1␤, IL-2, 11 IL-6, 8,12 IL-8 13 and IFN␥, 11,14 ), nitric oxide release, 15 matrix metalloproteinase (MMP) expression, 16,17 and induction of the cyclooxygenase-2 (Cox-2) pathway.…”

Section: Introductionmentioning

confidence: 98%

A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

et al. 2002

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“…Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine secreted by a variety of cell types, is a potent monocyte/macrophage chemoattractant and activator (22). MIF has an established role in RA (23,24), being elevated in synovial fluid, tissues, and serum of patients with RA (25,26). Inhibition of its function by antibody blockade, or through genetic deletion, significantly reduces the inflammation and destruction associated with mouse models of RA (27,28).…”

mentioning

confidence: 99%

Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis

Herrero

Nelson

Srikiatkhachorn

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Arthrogenic alphaviruses, such as Ross River virus (RRV), chikungunya, Sindbis, mayaro and o'nyong-nyong viruses circulate endemically worldwide, frequently causing outbreaks of polyarthritis. The exact mechanisms of how alphaviruses induce polyarthritis remain ill defined, although macrophages are known to play a key role. Macrophage migration inhibitory factor (MIF) is an important cytokine involved in rheumatoid arthritis pathogenesis. Here, we characterize the role of MIF in alphavirus–induced arthritides using a mouse model of RRV-induced arthritis, which has many characteristics of RRV disease in humans. RRV-infected WT mice developed severe disease associated with up-regulated MIF expression in serum and tissues, which corresponded to severe inflammation and tissue damage. MIF-deficient (MIF −/− ) mice developed mild disease accompanied by a reduction in inflammatory infiltrates and muscle destruction in the tissues, despite having viral titers similar to WT mice. In addition, reconstitution of MIF into MIF −/− mice exacerbated RRV disease and treatment of mice with MIF antagonist ameliorated disease in WT mice. Collectively, these findings suggest that MIF plays a critical role in determining the clinical severity of alphavirus–induced musculoskeletal disease and may provide a target for the development of antiviral pharmaceuticals. The prospect being that early treatment with MIF-blocking pharmaceuticals may curtail the debilitating arthritis associated with alphaviral infections.

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High Expression of Macrophage Migration Inhibitory Factor in the Synovial Tissues of Rheumatoid Joints

Cited by 91 publications

References 0 publications

Macrophage Migration Inhibitory Factor Up-regulates Expression of Matrix Metalloproteinases in Synovial Fibroblasts of Rheumatoid Arthritis

Macrophage Migration Inhibitory Factor Up-regulates Expression of Matrix Metalloproteinases in Synovial Fibroblasts of Rheumatoid Arthritis

A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis

Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis

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