High field structural MRI reveals specific episodic memory correlates in the subfields of the hippocampus

Travis, Scott G.; Huang, Yushan; Fujiwara, Esther; Radomski, Anna; Olsen, Fraser; Carter, R.; Seres, Peter; Malykhin, Nikolai

doi:10.1016/j.neuropsychologia.2013.11.016

Cited by 80 publications

(91 citation statements)

References 98 publications

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“…Volumes of CA2-3 and CA4-DG were also positively related to memory improvements after training in a study of older adults [42]. A recent study also indicates that the associations between hippocampal subfield volumes and memory performance vary along the longitudinal axis and differ for verbal and visuospatial tasks [71]. To our knowledge, however, the present study is the first to document relationships between hippocampal subfields and learning and memory in development.…”

Section: Discussionmentioning

confidence: 60%

Regional Hippocampal Volumes and Development Predict Learning and Memory

et al. 2014

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The hippocampus is an anatomically and functionally heterogeneous structure, but longitudinal studies of its regional development are scarce and it is not known whether protracted maturation of the hippocampus in adolescence is related to memory development. First, we investigated hippocampal subfield development using 170 longitudinally acquired brain magnetic resonance imaging scans from 85 participants aged 8-21 years. Hippocampal subfield volumes were estimated by the use of automated segmentation of 7 subfields, including the cornu ammonis (CA) sectors and the dentate gyrus (DG), while longitudinal subfield volumetric change was quantified using a nonlinear registration procedure. Second, associations between subfield volumes and change and verbal learning/memory across multiple retention intervals (5 min, 30 min and 1 week) were tested. It was hypothesized that short and intermediate memory would be more closely related to CA2-3/CA4-DG and extended, remote memory to CA1. Change rates were significantly different across hippocampal subfields, but nearly all subfields showed significant volume decreases over time throughout adolescence. Several subfield volumes were larger in the right hemisphere and in males, while for change rates there were no hemisphere or sex differences. Partly in support of the hypotheses, greater volume of CA1 and CA2-3 was related to recall and retention after an extended delay, while longitudinal reduction of CA2-3 and CA4-DG was related to learning. This suggests continued regional development of the hippocampus across adolescence and that volume and volume change in specific subfields differentially predict verbal learning and memory over different retention intervals, but future high-resolution studies are called for.

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Section: Discussionmentioning

confidence: 60%

Regional Hippocampal Volumes and Development Predict Learning and Memory

et al. 2014

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“…In addition, memory functions within the hippocampus in healthy younger subjects appear to be linked to particular hippocampal subregions and subfields (Travis et al, 2014). Therefore, the main goal of the present study was to investigate whether memory deficits in MDD patients are related to reduction in hippocampal subfields volumes, particularly DG and CA 1-3.…”

Section: Introductionmentioning

confidence: 94%

“…Recent neuroimaging studies (Das et al, 2011;Suthana et al, 2011;Travis et al, 2014;Yassa et al, 2011) suggest that the DG and CA1-3 may be particularly important for visuo-spatial memory processes including those involved in pattern separation. Studies have linked those subfields to memory performance in healthy younger (Travis et al, 2014) and older adults (Mueller et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Dentate gyrus volume and memory performance in major depressive disorder

Travis

Coupland

Silversone

et al. 2015

Journal of Affective Disorders

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“…The endowment of neuropsychological information that has been built from decades of academic study of people with DS strongly suggests that these individuals cannot adequately process verbal short-term memory (Baddeley and Jarrold 2007;Naess et al 2011), an ability that hinges on proper and timely feedback between the PFC (Andreasen et al 1995;Bunge et al 2000;Cabeza et al 1997;Cohen et al 1994;Hashimoto and Sakai 2002;Paulesu et al 1993), hippocampus (Ekstrom 2014;Karlsgodt et al 2005;Miller et al 2013;Mueller et al 2011;Schmidt-Wilcke et al 2009;Travis et al 2014), and cerebellum (Andreasen et al 1995;Chen and Desmond 2005;Ghosh et al 2008;Paulesu et al 1993;Ravizza et al 2004Ravizza et al , 2006. Deficient verbal memory might be, in fact, one of the signature cognitive deficits of DS, and work by several investigators has clarified that performance of individuals with trisomy is not an artifact of impaired hearing, phonetic discrimination/speech perception, language competence, cultural background, general forgetting, or word learning capacity (Brock and Jarrold 2004;Jarrold and Baddeley 1997;Frenkel and Bourdin 2009;Jarrold et al 2002;Laws 2002;Marcell and Cohen 1992;Marcell and Weeks 1988;Mosse and Jarrold 2010;Jarrold 2005, 2013).…”

Section: 2mentioning

confidence: 99%

Assessing Cognitive Improvement in People with Down Syndrome: Important Considerations for Drug-Efficacy Trials

Fernandez

Reeves

2015

Cognitive Enhancement

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Experimental research over just the past decade has raised the possibility that learning deficits connected to Down syndrome (DS) might be effectively managed by medication. In the current chapter, we touch on some of the work that paved the way for these advances and discuss the challenges associated with translating them. In particular, we highlight sources of phenotypic variability in the DS population that are likely to impact performance assessments. Throughout, suggestions are made on how to detect meaningful changes in cognitive-adaptive function in people with DS during drug treatment. The importance of within-subjects evaluation is emphasized.

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High field structural MRI reveals specific episodic memory correlates in the subfields of the hippocampus

Cited by 80 publications

References 98 publications

Regional Hippocampal Volumes and Development Predict Learning and Memory

Regional Hippocampal Volumes and Development Predict Learning and Memory

Dentate gyrus volume and memory performance in major depressive disorder

Assessing Cognitive Improvement in People with Down Syndrome: Important Considerations for Drug-Efficacy Trials

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