High-flow nasal cannula therapy for acute respiratory failure in patients with chest trauma: A single-center retrospective study

Mu, Gen Hua; Li, Xing; Lu, Zhong Qian; Hu, Shi; Chen, Ping Fa; Deng, Yi

doi:10.1016/j.injury.2020.07.064

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…Early application of NIV alleviated pulmonary edema and prevented its development, and shortened the duration of ventilatory support 18,41 . This study serves to broaden the indications for helmet use and provides a new option for patients with chest trauma in addition to NIV with a face mask 37 and high-flow nasal cannula therapy 42,43 .…”

Section: Discussionmentioning

confidence: 99%

Noninvasive ventilation with a helmet in patients with acute respiratory failure caused by chest trauma: a randomized controlled trial

Liu

Shan

Zhu

et al. 2020

Sci Rep

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Noninvasive ventilation (NIV) is beneficial in acute respiratory failure (ARF) caused by chest trauma; however, NIV-related complications affect the efficacy. We evaluated whether NIV with helmet decreases the incidence of complications and improves its effects in a single center. Patients with ARF after chest trauma were randomized to receive NIV with helmet or face mask. The primary outcome was the rate of NIV-related complications. Secondary outcomes were PaO2/FiO2, patient’s tolerance, intubation rate, length of intensive care unit (ICU) stay, and ICU mortality. The trial was terminated early after an interim analysis with 59 patients. The incidence of complications was lower in the helmet group [10% (3/29) vs 43% (13/30), P = 0.004], and PaO2/FiO2s were higher at 1 h and at the end of NIV (253.14 ± 64.74 mmHg vs 216.06 ± 43.86 mmHg, 277.07 ± 84.89 mmHg vs 225.81 ± 63.64 mmHg, P = 0.013 and 0.012) compared with them in face mask group. More patients reported excellent tolerance of the helmet vs face mask after 4 h of NIV [83% (24/29) vs 47% (14/30), P = 0.004] and at the end of NIV [69% (20/29) vs 30% (9/30), P = 0.03]. Differences in intubation rate, ICU stay, and mortality were non-significant (P = 0.612, 0.100, 1.000, respectively). NIV with helmet decreased NIV-related complications, increased PaO2/FiO2, and improved tolerance compared with NIV with face mask in patients with chest trauma.Trial registration: Registered in the Chinese Clinical Trial Registry (ChiCTR1900025915), a WHO International Clinical Trials Registry Platform (http://www.chictr.org.cn/searchprojen.aspx).

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