High-frequency hearing and reflex latency in patients with pigment disorder

Ardıç, Fazíl Necdet; Aktan, Şebnem; Kara, Cüneyt Orhan; Şanlı, Berna

doi:10.1016/s0196-0709(98)90038-2

Cited by 43 publications

(52 citation statements)

References 19 publications

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“…This result can be due to the destruction of melanocytes in the inner ear which have multiple roles critical for hair cell survival, including maintenance of the normal function of the stria vascularis and the cochlea, the development of endocochlear potentials and ion and fluid gradient between the endolymph and perilymph. In studies on this theme, the evaluation of hearing revealed similar results, i.e., decreased hearing at high frequencies [16][17][18]. Ardiç et al [18] explained that Vitiligo seems to be an effective factor in hearing loss and that the mechanism for this condition might be absence of the preventive function of melanocytes in the inner ear.…”

Section: Discussionmentioning

confidence: 89%

“…In studies on this theme, the evaluation of hearing revealed similar results, i.e., decreased hearing at high frequencies [16][17][18]. Ardiç et al [18] explained that Vitiligo seems to be an effective factor in hearing loss and that the mechanism for this condition might be absence of the preventive function of melanocytes in the inner ear. Tosti et al [19] found hearing loss in 16 % of subjects with Vitiligo; they raised the hypothesis that part of the melanocytes was injured by auto-immunity due to Vitiligo.…”

Section: Discussionmentioning

confidence: 89%

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Audiological and Electrophysiological Changes in Patients with Vitiligo

Arya

Munjal

Panda

et al. 2015

Indian J Otolaryngol Head Neck Surg

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The study was conducted to evaluate the audiological and electrophysiological findings in patients with Vitiligo and to compare the findings with otologically and audiologically normal controls. Study group included 50 subjects (25 Males, 25 Females) with Vitiligo (Mean age-27.4 years) and control group contained 40 age-matched normal hearing subjects. Pure tone audiometry (PTA) with extended high frequency audiometry, Otoacoustic emissions (OAEs), Tympanometry, Auditory brainstem responses (ABR) and Middle latency responses (MLR) were conducted in all subjects. Comparison of the study group with the control group showed statistically significant differences (p \ 0.05) on PTA, in Transient otoacoustic emissions (TOAEs) at 1, 2, 3, 4 kHz and in distortion product otoacoustic emissions (DPOAEs) at 357, 499, 704, 1003 Hz. On ABR, statistically significant differences were observed between the groups in wave I (p \ 0.01) in both ears, wave V (p \ 0.05) in left ear and on interpeak latency of I-III (p \ 0.01, p \ 0.05), III-V (p \ 0.01 in left ear) and I-V (p \ 0.01, p \ 0.05) in left and right ears respectively. When patients with localized vitiligo were compared with generalized vitiligo, the SNR of TOAEs was highly significant in both ears at 2 KHz (p \ 0.05), 3 kHz (p \ 0.01) and 4 kHz (p \ 0.05). PTA average of 2 KHz, 4 and 8 kHz (PTA2) showed a significant difference (p \ 0.01) when localized vitiligo was compared to generalized vitiligo. Results support possible auditory and electrophysiological changes in Vitiligo patients along with decreased cochlear function.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

Audiological and Electrophysiological Changes in Patients with Vitiligo

Arya

Munjal

Panda

et al. 2015

Indian J Otolaryngol Head Neck Surg

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“…However, when compared with the control group, the authors found statistically significant differences only in high frequency audiometry. Ardic et al (1998) 7 studied 29 subjects with vitiligo compared with a 41-subject control group, applying audiometry from 250 Hz to 16 KHz. This author found pure tone thresholds between 4 000 Hz and 10 000 Hz in the vitiligo group, which was significantly worse compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

“…It is thus thought that melanin has a protective role against harmful agents in the inner ear. 4,5,7 Loss of melanocytes, resulting in decreased melanin production -as occurs in Vitiligo -could decrease cochlear health.…”

Section: Introductionmentioning

confidence: 99%

Portadores de vitiligo: estudo das emissões otoacústicas e efeito de supressão

Angrisani¹,

Azevedo

Pereira

et al. 2009

Rev. Bras. Otorrinolaringol.

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Vi tiligo is a skin disease characterized by absence of melanin due to melanocytes destruction. Aim: to study the incidence of hearing alterations in patients with vitiligo. Method: prospective audiological evaluation, transientevoked otoacoustic emission recordings and study the effects of suppression in 24 patients with vitiligo. Their ages ranged from 15 to 45 years. Results: 21 patients (87.5%) had normal audiometry; 2 had unilateral hearing loss in the high frequencies and 1 had cochlear moderate hearing loss in the left ear. Of these 21 subjects, 66.7% had no otoacoustic emissions, suggesting cochlear dysfunction. Only 7 patients had otoacoustic emissions present in all frequencies (29.2%) and 17 (70.8%) did not have them, and the highest rate of no otoacoustic emissions happened in the right ear of males. Regarding the suppression study, 6 subjects failed, all of them were females, and their left ears were the most affected. Conclusion: the findings show that patients with vitiligo, particularly males, have a greater predisposition to cochlear dysfunction, especially in the right ear. As far as the suppression effect was concerned, there was a greater alteration in the female efferent system, particularly in the left ear. Hearing alterations did not vary as far as age is concerned, type of vitiligo and time of disease progression.

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“…Although vitiligo affects all races equally, it is more noticeable in dark-skinned people. (Figure 2) [26][27][28][29][30]. …”

Section: Causesmentioning

confidence: 99%