High-frequency percussive ventilation in acute respiratory failure

Abstract

IntroductionHigh-Frequency Percussive Ventilation (HFPV) is a ventilation mode characterised by high-frequency breaths. This study investigated the impact of HFPV on gas exchange and clinical outcomes in acute respiratory failure (ARF) patients during spontaneous breathing, non-invasive ventilation (NIV), and invasive mechanical ventilation (iMV).MethodsThis systematic review included randomised and nonrandomised studies up to August 2023. Inclusion criteria focused on adult ARF patients, HFPV application, comparisons with other ventilation modes, and outcomes related to oxygenation and clinical parameters. A pooled data analysis was performed comparing HFPV with iMV concerning gas exchange, pulmonary infection, and mortality.ResultsOf the 51 identified records, 29 met the inclusion criteria. HFPV was safely and effectively applied to ARF patients during spontaneous breathing or NIV, improving oxygenation. For patients who underwent iMV, HFPV significantly enhanced oxygenation and the arterial partial pressure of carbon dioxide, reduced pulmonary infection occurrence, and improved survival. Barotrauma rates were not elevated with HFPV, and hemodynamic stability remained unaffected. HFPV was also utilised in patients undergoing Extra-Corporeal Membrane Oxygenation, resulting in improved lung recruitment and oxygenation.ConclusionHFPV had favourable effects on physiological and certain clinical outcomes in ARF patients. However, the overall evidence quality remains weak, necessitating large-scale randomised controlled trials for definitive conclusions.