High Frequency Ultrasound Elastography for Estimating the Viscoelastic Properties of the Cornea Using Lamb Wave Model

Weng, Chien-Chang; Chen, Pei-Yu; Chou, Dean; Shih, Cho-Chiang; Huang, Chih-Chung

doi:10.1109/tbme.2020.3044066

Cited by 19 publications

(6 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Weng et al believe that ultrasound is an important bedside technology in emergency medicine, and clinicians can use ultrasound instruments to check and obtain results by themselves, which can make early diagnosis and timely treatment, which is of great value for the diagnosis and treatment of critically ill patients. Lung ultrasound has been used in the diagnosis of adult lung diseases, and the lung ultrasound score can assess the ventilation function and oxygenation status of the adult lungs [ 4 ]. Kim et al suggested that compared with adults, neonatal adipose tissue, small lung volume, and thin muscle layer are more conducive to the diagnosis of lung diseases such as RDS, TTN, MAS, and neonatal pneumonia by lung ultrasound.…”

Section: Literature Reviewmentioning

confidence: 99%

[Retracted] Clinical Value and Imaging Features of Bedside High‐Frequency Ultrasound Imaging in the Diagnosis of Neonatal Pneumonia

Zhu¹,

Chen²,

Jiang³

2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

The aim is to solve the problem of the urgent need of a nonradiation, noninvasive, and simple-to-operate diagnostic method for neonatal pneumonia that can indicate the severity of the disease and dynamically monitor the outcome of the disease. The authors propose a bedside high-frequency ultrasound technique based on methods for evaluation in the detection and treatment of neonatal pneumonia. The results obtained are as follows: the sensitivity of neonatal lung ultrasound in the diagnosis of neonatal pneumonia was 96.6%, the specificity was 93.3%, the positive predictive value was 93.5%, and the negative predictive value was 96.5%. The sensitivity of chest X-ray in the diagnosis of neonatal pneumonia was 93.3%. Compared with the lung ultrasound and chest X-ray in the diagnosis of neonatal pneumonia, the two had a good correlation. The neonatal respiratory score was positively correlated with the lung ultrasound score, and the higher the lung ultrasound score, the more severe the disease. The score decreased by 35% after 3 days of treatment and 68% after 7 days of treatment, indicating that the lung high-frequency ultrasound score can be very effective in characterizing the treatment situation. It has been demonstrated that the lung ultrasound can be used as an imaging method for the diagnosis of neonatal pneumonia. The higher the lung ultrasound score, the more severe the disease, and the lung ultrasound score was positively correlated with the disease severity. With dynamic monitoring of the lung ultrasound and the gradual improvement of clinical symptoms after treatment, the lung ultrasound score gradually decreased; therefore, the lung ultrasound can be used for re-examination of neonatal pneumonia to evaluate the treatment effect and guidance.

show abstract

Section: Literature Reviewmentioning

confidence: 99%

[Retracted] Clinical Value and Imaging Features of Bedside High‐Frequency Ultrasound Imaging in the Diagnosis of Neonatal Pneumonia

Zhu¹,

Chen²,

Jiang³

2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

show abstract

“…Furthermore, previous studies do not provided the high spatial resolution because these imaging systems use the commercial ultrasound probes which do not have enough center frequency. However, high-frequency ultrasound imaging in mechanical wave elastography would be beneficial for the better diagnostics of the diseases as shown in the previous study [3]. Thus, highfrequency ultrasound elastrography is required.…”

Section: Discussionmentioning

confidence: 85%

“…The quantification of directional mechanics of each layer would be beneficial for the better diagnostics of the heart diseases. In addition, high-frequency ultrasound imaging showed the usefulness for eleastography of tissues with thickness less than few millimeters in the previous study [3]. Thus, high-frequency ultrasound elastrography is required.…”

Section: Introductionmentioning

confidence: 90%

Ex Vivo Evaluation of Mechanical Anisotropic Tissues with High-Frequency Ultrasound Shear Wave Elastography

Lee

Eun

Hwang

et al. 2022

Sensors

View full text Add to dashboard Cite

The use of imaging devices to assess directional mechanics of tissues is highly desirable. This is because the directional mechanics depend on fiber orientation, and altered directional mechanics are closely related to the pathological status of tissues. However, measuring directional mechanics in tissues with high-stiffness is challenging due to the difficulty of generating localized displacement in these tissues using acoustic radiation force, a general method for generating displacement in ultrasound-based elastography. In addition, common ultrasound probes do not provide rotational function, which makes the measurement of directional mechanics inaccurate and unreliable. Therefore, we developed a high-frequency ultrasound mechanical wave elastography system that can accommodate a wide range of tissue stiffness and is also equipped with a motorized rotation stage for precise imaging of directional mechanics. A mechanical shaker was applied to the elastography system to measure tissues with high-stiffness. Phantom and ex vivo experiments were performed. In the phantom experiments, the lateral and axial resolution of the system were determined to be 144 μm and 168 μm, respectively. In the ex vivo experiments, we used swine heart and cartilage, both of which are considered stiff. The elastography system allows us to acquire the directional mechanics with high angular resolution in the heart and cartilage. The results demonstrate that the developed elastography system is capable of imaging a wide range of tissues and has high angular resolution. Therefore, this system might be useful for the diagnostics of mechanically anisotropic tissues via ex vivo tests.

show abstract

“… 24 , 25 Qian et al 26 used a confocal 40-MH needle ultrasound transducer to assess the corneal Young's modulus after formalin treatment at different IOPs. Weng et al 27 used a high-frequency ultrasound array method for ultrafast ultrasound imaging and a Lamb wave model to assess the porcine cornea viscoelasticity. Zhang et al 28 , 29 used a mechanical shaker probe combined with high-frequency ultrasonic elastography to assess the biomechanics of the anterior ocular segment and whole eye tissue.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus

Zhao,

Zhu,

Yan

et al. 2024

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose Validation of the feasibility of novel acoustic radiation force optical coherence elastography (ARF-OCE) for the evaluation of biomechanical enhancement of the in vivo model of keratoconus by clinical cross-linking (CXL) surgery. Methods Twelve in vivo rabbit corneas were randomly divided into two groups. Both groups were treated with collagenase type II, and a keratoconus model was obtained. Then, the two groups were treated with CXL procedures with different irradiation energy of 15 J and 30 J (CXL-15 J and CXL-30 J, respectively). An ARF-OCE probe with an ultrasmall ultrasound transducer was used to detect the biomechanical properties of cornea. An antisymmetric Lamb wave model was combined with the frequency dispersion relationship to achieve depth-resolved elastography. Results Compared with the phase velocity of the Lamb wave in healthy corneas (approximately 3.96 ± 0.27 m/s), the phase velocity of the Lamb wave was lower in the keratoconus region ( P < 0.05), with an average value of 3.12 ± 0.12 m/s. Moreover, the corneal stiffness increased after CXL treatment ( P < 0.05), and the average phase velocity of the Lamb wave was 4.3 ± 0.19 m/s and 4.54 ± 0.13 m/s after CXL-15 J and CXL-30 J treatment. Conclusions The Young's moduli of the keratoconus regions were significantly lower than the healthy corneas. Moreover, the Young's modulus of the keratoconus regions was significantly higher after CXL-30 J treatment than after CXL-15 J treatment. We demonstrated that the ARF-OCE technique has great potential in screening keratoconus and guiding clinical CXL treatment. Translational Relevance This work accelerates the clinical translation of OCE systems using ultrasmall ultrasound transducers and is used to guide CXL procedures.

show abstract

High Frequency Ultrasound Elastography for Estimating the Viscoelastic Properties of the Cornea Using Lamb Wave Model

Cited by 19 publications

References 45 publications

[Retracted] Clinical Value and Imaging Features of Bedside High‐Frequency Ultrasound Imaging in the Diagnosis of Neonatal Pneumonia

[Retracted] Clinical Value and Imaging Features of Bedside High‐Frequency Ultrasound Imaging in the Diagnosis of Neonatal Pneumonia

Ex Vivo Evaluation of Mechanical Anisotropic Tissues with High-Frequency Ultrasound Shear Wave Elastography

In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus

Contact Info

Product

Resources

About