High Genetic Diversity of Newcastle Disease Virus in Poultry in West and Central Africa: Cocirculation of Genotype XIV and Newly Defined Genotypes XVII and XVIII

Snoeck, Chantal J.; Owoade, A. A.; Couacy‐Hymann, Emmanuel; Alkali, B. R.; Okwen, Patrick; Adeyanju, Adeniyi T.; Komoyo, Giscard F.; Nakouné, Emmanuel; Faou, Alain Le; Muller, Claude P.

doi:10.1128/jcm.00684-13

Cited by 178 publications

(191 citation statements)

References 57 publications

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“…Over the years, epizootiology of ND in Nigeria has been based mostly on conventional methods viz: serological [6,69,71,75,83,85,92] and virus isolation with biological characterization [5,28,40,48,62,70,74,96]. Recently, however, attempts were made by using molecular techniques at defining the genotypes and molecular epidemiology of the circulating virus in West and Central Africa including Nigeria [19,99,[101][102][103]108].…”

Section: Epizootiology Of Nd In Nigeriamentioning

confidence: 99%

“…1a) each has been described and are responsible for the current ND outbreaks being experienced across the sub-region. These genotypes and sub-genotypes are in circulation and have not been detected elsewhere outside the sub-region, making them indigenous [19,95,99,[101][102][103]108]. All NDV genotypes that have been reported to be circulating in Nigeria are shown in Fig.…”

Section: Epizootiology Of Nd In Nigeriamentioning

confidence: 99%

“…Initially, due to the genetic relatedness of the currently circulating genotypes indigenous to West Africa, earlier studies on NDV genotyping in West Africa, grouped the viruses to lineage 5 and 7 (genotype XIV and VII) [19,94,99]. The classification was later streamlined to genotypes XIV, XVII, and XVII with the existence of the unified nomenclature for the classification of NDV as proposed by Diel et al [25] and expanded by Snoeck et al [101]. Movements of poultry and poultry products within and outside states and the sub-region have assisted in the spread of the disease.…”

Section: Challenges and Way Forwardmentioning

confidence: 99%

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Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

2016

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Over the years, Newcastle disease (ND) has defied all available control measures. The disease has remained at the forefront of infectious diseases afflicting poultry production after avian influenza. Despite the continuous global use of million doses of ND vaccine annually, the causative pathogen, avian paramyxovirus type 1 also known as Newcastle disease virus (NDV) has continued to evolve causing, even more, a threat not only to the unvaccinated but the vaccinated flocks inclusive. The disease has been well studied in the developed countries where the virus is found in circulation. However, limited information exists on the epizootiology and circulating genotypes of the virus in developing countries where the majority of the flocks are raised on the extensive management system. Identification of virulent NDV in apparently healthy free-range ducks in this system calls for concern and pragmatic approach to investigate factor(s) that favour the virus inhabiting the ducks without clinical manifestation of the disease. Recently, novel genotypes (XIV, XVII, and XVIII) with peculiarity to West and Central African countries have been discovered and due to lack or poor surveillance system possibility of hitherto unreported genotypes are likely. This review elucidates and discusses available literature on the diversity of the circulating NDV genotypes across the West Africa countries and the epizootiology (molecular) of the disease in Nigeria with the view of identifying gaps in knowledge that can assist in the development of effective vaccines and control strategies to combat the peril of the disease.

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Section: Epizootiology Of Nd In Nigeriamentioning

confidence: 99%

Section: Epizootiology Of Nd In Nigeriamentioning

confidence: 99%

Section: Challenges and Way Forwardmentioning

confidence: 99%

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Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

2016

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“…Class I viruses are mostly loNDV found in wild birds, and contain nine genotypes (1-9), but class II viruses were originally broken into multiple genotypes representing loNDV and vNDV. Almost all virulent NDV strains isolated from wild and domestic birds belong to class II, which can be further subdivided into at least 18 genotypes from I to XVIII [12].…”

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confidence: 99%

Molecular characterization and phylogenetic study of the fusion genes of Newcastle disease virus from the recent outbreaks in Ahvaz, Iran

2016

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Newcastle disease (ND) is an acute and highly contagious disease affecting many domestic and wild species of birds. Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an epizootic on the poultry industry. In this study, partial sequences of fusion genes of three Newcastle disease virus (NDV) isolates collected during 2013-14 outbreaks from the vaccinated commercial broiler chicken farms with high mortality around Ahvaz city (Southwest of Iran) were characterized. All three isolates showed the amino acid sequence 112RRQKRF117 at the C-terminus of the F2 protein and phenylalanine at the N-terminus of the F1 protein residue 117. These amino acid sequences were identical to a known virulent motif. The phylogenetic analysis revealed that the Iranian ND isolates in this study are closely related to the genotype VIId of class II NDV strains. Our results specified that there are velogenic NDV circulating in Ahvaz commercial broiler flocks and causing outbreaks in poultry industry.

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“…According to F genes, NDVs can be categorized into classes I and II (Diel et al, 2012). Class I has nine genotypes, while class II has at least 18 genotypes identified so far (Kim et al, 2007;Snoeck et al, 2013). Virulence intensity of NDVs can be classified according to basic amino acid sequences from 112 to 117 of the F protein as virulent (112R/K-R-Q-K/R-R 117) or with low virulence (112 G/E-K/R-Q-G/E-R-L 117), according to Kim et al(2008).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic and Pathotypic Characterization of a Newcastle Disease Virus Strain Isolated from Ducks and Pigeons in Hubei, China

Wang

Zhang

et al. 2018

Rev. Bras. Cienc. Avic.

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Newcastle disease is a highly contagious disease responsible for major outbreaks and considerable economic losses in the poultry industry in China. There is still little information available regarding gene characterization of the NDV, especially in ducks and pigeons. Therefore, the aim of this study was to investigate NDV isolated from ducks and pigeons in Hubei, China. In this study, three NDVs from ducks and pigeons were isolated between 2013 and 2015.The fusion protein (F) gene of the NDV isolates was sequenced and phylogenetically analyzed. The clinical signs and gross histopathological lesions were examined. Phylogenetic analysis of these strains indicated that all the sequences are classified as genotype II. The isolates shared a 112 G-R-Q-G-R-L 117motif at the F protein cleavage site, indicating that these three isolates strains are lentogenic. Necropsy and histopathology showed the typical pathological changes. It was concluded that commercial ducks and pigeons in Hubei province carry lentogenic NDV strains with regular genetic divergence, indicating that these species may act as the main reservoirs of NDV in poultry. Therefore, strategies and surveillance should be undertaken to reduce the risk of ND outbreaks.

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High Genetic Diversity of Newcastle Disease Virus in Poultry in West and Central Africa: Cocirculation of Genotype XIV and Newly Defined Genotypes XVII and XVIII

Cited by 178 publications

References 57 publications

Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

Newcastle disease in Nigeria: epizootiology and current knowledge of circulating genotypes

Molecular characterization and phylogenetic study of the fusion genes of Newcastle disease virus from the recent outbreaks in Ahvaz, Iran

Phylogenetic and Pathotypic Characterization of a Newcastle Disease Virus Strain Isolated from Ducks and Pigeons in Hubei, China

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