High glutamine increases stroke risk by inducing the endothelial‐to‐mesenchymal transition in moyamoya disease
Qiheng He,
Junsheng Li,
Chuming Tao
et al.
Abstract:At present, there is limited research on the mechanisms underlying moyamoya disease (MMD). Herein, we aimed to determine the role of glutamine in MMD pathogenesis, and 360 adult patients were prospectively enrolled. Human brain microvascular endothelial cells (HBMECs) were subjected to Integrin Subunit Beta 4 (ITGB4) overexpression or knockdown and atorvastatin. We assessed factors associated with various signaling pathways in the context of the endothelial‐to‐mesenchymal transition (EndMT), and the expression… Show more
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