High hemoglobin is associated with increased in-hospital death in patients with chronic obstructive pulmonary disease and chronic kidney disease: a retrospective multicenter population-based study

Xu, Le; Chen, Yuanhan; Xie, Zhen; He, Qiang; Chen, Shixin; Liu, Guohui; Liao, Yuanjiang; Chen, Lu; Hao, Li; Sun, Jin; Shi, Wei; Liang, Xinling

doi:10.1186/s12890-019-0933-4

Cited by 13 publications

(18 citation statements)

References 35 publications

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“…Multivariate regression analyses also confirmed the associations seen between each of those blood parameters with female gender. Differences in hemoglobin levels were also reported in male and female patients with COPD, in whom this blood parameter was demonstrated to have predictive value during hospitalizations and at hospital discharge [ 25 , 26 ]. As far as we are concerned, these are novel findings in patients with bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Wang

Villa²,

Dobarganes³

et al. 2021

Biomedicines

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We hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung function, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored.

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Section: Discussionmentioning

confidence: 99%

Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Wang

Villa²,

Dobarganes³

et al. 2021

Biomedicines

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“… 1 COPD is characterized by progressive and persistent airflow limitation resulting in chronic sustained hypoxia and acquired polycythemia, and the latter is closely associated with an increased risk of stroke, venous thromboembolism (VTE), pulmonary hypertension (PH), and mortality. 2 , 3 Furthermore, polycythemia remains present in 2–10% of COPD patients even after long-term oxygen therapy. 4–6…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

Zeng¹,

Yan²,

He³

et al. 2022

COPD

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Purpose Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are associated with polycythemia. However, there still remain unanswered questions about the relationship between overlap syndrome (OVS), where OSA and COPD coexist, and polycythemia. Here, we aimed to establish the prevalence of polycythemia in OVS patients and to explore the impact of OSA on polycythemia. Patients and Methods Patients with COPD underwent overnight polysomnography (PSG), pulmonary function tests, echocardiography, and complete blood counts. All patients were ethnic Han Chinese and free of prolonged oral corticosteroid use, hematological system disease, severe systemic disease, and other sleep-disordered breathing. OVS was defined as COPD patients with an apnea–hypopnea index ≥15 events/h, and polycythemia was defined as an Hb >165 g/L in men and >160 g/L in women. Results Eight-hundred and eighty-six patients with COPD were included in the analysis. The prevalence of polycythemia was significantly higher in OVS patients than COPD-alone patients (6.4% vs 2.9%, p < 0.05). The prevalence of polycythemia increased with OSA severity ( χ 2 = 7.885, p = 0.007), but not in GOLD grade 3–4 COPD patients ( χ 2 = 0.190, p = 0.663). After adjusting for confounders, percentage of total sleep time with SaO 2 <90% (TS 90 ) remained independently associated with an increased odds of polycythemia (OR 1.030, 95% CI 1.015–1.046) and, with an increase in TS 90 , the hemoglobin increased, especially in GOLD grade 1–2 patients ( p < 0.05). Conclusion Patients with OVS have a higher prevalence of polycythemia than those with COPD alone, and TS 90 is an independent factor for polycythemia, especially in GOLD1-2 COPD patients.

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“…Cigarette smoking and chronic obstructive pulmonary disease (COPD) are associated with secondary polycythemia [ 1 , 2 ], which may contribute to pulmonary hypertension (PH) [ 3 , 4 ], venous thromboembolism [ 5 – 7 ], and mortality in COPD [ 8 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

et al. 2021

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Background Secondary polycythemia is associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). However, the prevalence of polycythemia in COPD and the contributing risk factors for polycythemia in COPD have not been extensively studied. Methods We analyzed the presence of secondary polycythemia in current and former smokers with moderate to very severe COPD at the five-year follow-up visit in the observational COPDGene study. We used logistic regression to evaluate the association of polycythemia with age, sex, race, altitude, current smoking status, spirometry, diffusing capacity for carbon monoxide (DLCO), quantitative chest CT measurements (including emphysema, airway wall thickness, and pulmonary artery to aorta diameter ratio), resting hypoxemia, exercise-induced hypoxemia, and long-term oxygen therapy. Results In a total of 1928 COPDGene participants with moderate to very severe COPD, secondary polycythemia was found in 97 (9.2%) male and 31 (3.5%) female participants. In a multivariable logistic model, severe resting hypoxemia (OR 3.50, 95% CI 1.41–8.66), impaired DLCO (OR 1.28 for each 10-percent decrease in DLCO % predicted, CI 1.09–1.49), male sex (OR 3.60, CI 2.20–5.90), non-Hispanic white race (OR 3.33, CI 1.71–6.50), current smoking (OR 2.55, CI 1.49–4.38), and enrollment in the Denver clinical center (OR 4.42, CI 2.38–8.21) were associated with higher risk for polycythemia. In addition, continuous (OR 0.13, CI 0.05–0.35) and nocturnal (OR 0.46, CI 0.21–0.97) supplemental oxygen were associated with lower risk for polycythemia. Results were similar after excluding participants with anemia and participants enrolled at the Denver clinical center. Conclusions In a large cohort of individuals with moderate to very severe COPD, male sex, current smoking, enrollment at the Denver clinical center, impaired DLCO, and severe hypoxemia were associated with increased risk for secondary polycythemia. Continuous or nocturnal supplemental oxygen use were associated with decreased risk for polycythemia.

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High hemoglobin is associated with increased in-hospital death in patients with chronic obstructive pulmonary disease and chronic kidney disease: a retrospective multicenter population-based study

Cited by 13 publications

References 35 publications

Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study

Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

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