High incidence and recurrence of transitional cell carcinoma in Taiwanese patients with end‐stage renal disease

Abstract

The data shows that Taiwanese patients with ESRD had high incidence (0.9%) and recurrence (35.7%) of TCC.

Does Chinese Herb Nephropathy Account for the High Incidence of End-Stage Renal Disease in Taiwan?

“…It has been shown that patients who underwent renal transplant in Taiwan had a high cumulative incidence of TCC [33], accounting for 50% of all malignancies occurring after transplantation. In the present study, the cumulative rate of TCC in all ESRD patients was compatible with that of patients with previous reports [34,35]. Because of the late onset of TCC in these patients, long-term follow-up is highly suggested, especially for patients with a previous history of upper urinary tract urothelial carcinoma [36].…”

Shorter hemodialysis duration is a risk factor for the recurrence of urothelial carcinoma of the bladder in patients on maintenance hemodialysis

“…In Asia, UC of the bladder (UCB) is the major cancer affecting MHD patients [8,16]. In the present study, for the first time, we showed that shorter HDD is an independent risk factor for the occurrence and recurrence of UCB, although the SIR of bladder cancer in maintenance hemodialysis patients has been reported to be higher than that of their healthy counterparts [7].…”

“…In particular, Chen et al reported a high frequency of UC in uremic patients [17]. Several hypotheses are proposed to explain this finding, including impaired DNA repair ability, immune defects, nutritional deficiencies, and chronic urinary tract infection [2,8,16]. Wu et al evaluated 73 patients with upper urinary tract urothelial carcinoma (UUT-UC) on dialysis therapy and identified a high recurrence rate in these patients [12].…”

“…Standardized incidence ratios (SIR) for bladder cancer were increased in all categories of primary renal diseases except diabetes and familial, hereditary diseases [7]. On the other hand, bladder cancers in patients requiring MHD often present aggressive histological features [8]. To date, several studies have suggested that conservative therapy in patients with noninvasive tumors appears to be well-tolerated while urinary tract exenteration is associated with high morbidity and mortality [9,10].…”

Urothelial Carcinoma in Renal Transplant Recipients

“…Physicians who are taking care of hemodialysis patients and renal transplant recipients should be highly alert with presence of hematuria which warrants detailed study of the entire urinary system and image study of the native and transplanted kidneys Tai et al, 2009;Liao et al, 2004). Only 19.4% of patients had history of long-term consumption of Chinese herbs and 3.1% had history of using analgesic compounds (Wang et al, 2011). Contamination of drinking water is considered to be another carcinogenic factor.…”