High intraocular pressure is associated with cardiometabolic risk factors in South Korean men: Korean National Health and Nutrition Examination Survey, 2008–2010

Chung

2015

Eye

Purpose Many studies have reported associations between elevated intraocular pressure (IOP) and systemic health parameters, which suggest a common mechanism links IOP elevation and various related cardiometabolic risk factors. Furthermore, according to a recent study, serum apolipoprotein B (APO B) level is a predictor of coronary artery disease. This study was undertaken to analyse the relationship between serum apolipoprotein levels and IOP.

Section: Discussionsupporting

confidence: 66%

Section: Discussioncontrasting

confidence: 43%

Apolipoprotein B: novel indicator of elevated intraocular pressure

Chung

2015

Eye

Bosn J of Basic Med Sci

“…Indeed, there is research showing increased levels of TC, TG and LDL, and decreased HDL in POAG and NTG patients [35][36][37]. Furthermore, one population analysis has linked dyslipidemia with increased IOP in people not receiving glaucoma treatment, suggesting that hyperlipidemia may play a role in the onset of glaucoma [38]. In this study, we have found higher levels of TC in glaucoma patients and TG in NTG patients only, compared to healthy controls.…”

Section: Discussionsupporting

confidence: 60%

Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma

Yılmaz¹,

Çoban²,

Bayındır³

et al. 2015

This study entailed a cross-examination of oxidant/antioxidant balance, high-density lipoprotein (HDL)-linked paraoxonase 1 (PON1) phenotypes, and levels of serum routine lipids among patients with normal tension glaucoma (NTG) or pseudoexfoliative glaucoma (PEXG) compared with healthy control groups. We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma. The study included 32 patients with NTG, 31 patients with PEXG, and 40 control subjects. Levels of PON1 and arylesterase enzymatic activity, total oxidant status (TOS), and total antioxidant status were measured by spectrophotometry and OS indexes (OSI) were calculated. The phenotype distribution of PON1 was determined using the dual substrate method. Blood serum levels of HDL, low-density lipoprotein, total cholesterol (TC), and triglyceride (TG) were measured. The TOS and OSI values in the NTG group were significantly higher compared with the other groups (both p < 0.01). The phenotype distribution found in the glaucoma and control groups were NTG: QQ, 59.4%; QR, 37.5%; RR, 3.1%; PEXG: QQ, 45.1%; QR, 48.4%; RR, 6.5%; and in the control group: QQ, 42.5%; QR, 50.0%; RR, 7.5%. Serum TC levels were significantly higher than the control in both NTG and PEXG groups, whereas TG was significantly higher in NTG only (p < 0.01 and p < 0.02, respectively). Hyperlipidemia, OS and variations in phenotype distribution of PON1 may play a role in the pathogenesis of different types of glaucoma.

“…High BP and diabetes are well known established risk factors associated with cardiovascular disease (CVD). Furthermore, several studies have demonstrated the positive association between IOP and cardiometabolic risk factors or metabolic syndrome 6 7. Therefore, the relationship between IOP and cardiovascular risk factors raises the possibility that increased IOP may be associated with CVD.…”

Section: Introductionmentioning

confidence: 99%

Intraocular pressure and coronary artery calcification in asymptomatic men and women

Chang

Kim

et al. 2015

Br J Ophthalmol