High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

Faienza, Maria Felicia; Brunetti, Giacomina; Sanesi, Lorenzo; Colaianni, Graziana; Celi, Monica; Piacente, Laura; Damato, G.; Schipani, Ernestina; Colucci, Silvia; Grano, Maria

doi:10.1016/j.diabres.2018.03.046

Cited by 68 publications

(55 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These authors found a negative correlation between HbA1c and vitamin D in T1DM patients, while a positive one was found with bone mineral density and bone remolder markers evaluated by the BTT-Z score and osteocalcin, respectively. Their results highlighted that in T1DM children and adolescents on continuous subcutaneous insulin infusion, elevated irisin levels predicted a better metabolic control and the possible association through irisin of a better glycemic control and bone health [ 36 ].…”

Section: Irisin and Type 1 Diabetesmentioning

confidence: 99%

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Muñoz

Camarillo-Romero

García

2018

International Journal of Endocrinology

View full text Add to dashboard Cite

The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin has also been described as a hormone that may have a key role in glucose homeostasis. The way the association of type 2 diabetes with obesity occurs is not fully understood. In recent years, the possible pathways through which irisin could interact with other organs such as the brain or bone have been described. The present paper intends to review the new findings and possible new directions in irisin research.

show abstract

Section: Irisin and Type 1 Diabetesmentioning

confidence: 99%

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Muñoz

Camarillo-Romero

García

2018

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…However, its importance is still not fully understood. The localization of this peptide has been determined in many tissues [37][38][39]. Gur et al [40] determined that irisin is located in the cytoplasm of the cells of all examined tissues including testis.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of Vitamin D on imidacloprid-induced testicular injury in rats

2019

View full text Add to dashboard Cite

Introduction: The degenerative effects of imidacloprid via oxidative stress are known. Irisin is a recently discovered peptide with energy regulator and antioxidant effects. In addition, the antioxidant potential of Vitamin D has been reported in previous studies. The current study was performed to investigate the effect of Vitamin D on testis morphology and irisin immunoreactivity in imidacloprid-treated rats. Material and methods: Thirty-two Wistar albino male rats were divided into groups: control (n = 6), corn oil (n = 6), Vitamin D (n = 6), imidacloprid (n = 7) and imidacloprid + Vitamin D (n = 7). Testis tissues were used to evaluate the histopathological, biochemical and immunohistochemical changes. Oxidative state in testis tissue was determined with total antioxidant and oxidant status markers, total antioxidant status (TAS) and total oxidant status (TOS) respectively. Results: In microscopic examination, degenerative changes in the seminiferous tubule epithelium, interstitial edema and increased irisin immunoreactivity were observed in animals given imidacloprid. Also increased TOS and decreased TAS levels were measured in these animals. It was observed that Vitamin D improved the testicular damage histopathologically when compared to the imidacloprid group. However, increase in TAS levels and decrease in both TOS levels and irisin immunoreactivity were found insignificant in animals given Vitamin D. Conclusions: In the present study it was observed that Vitamin D ameliorated testis injury caused by imidacloprid. Furthermore, imidacloprid was found to increase the immunoreactivity of irisin. In the light of our findings, we conclude that the use of Vitamin D could be beneficial against testicular damage caused by imidacloprid.

show abstract

“…In healthy children, irisin levels are positively correlated with bone mineral status and circulating osteocalcin [26]. High irisin levels have also been observed in children and adolescents with type 1 diabetes mellitus (T1DM), as they are associated with a better metabolic control and improved bone mass [27]. These evidences suggest that irisin might be considered as one of the bone formation markers during childhood.…”

Section: Physical Activity and Bone Health: The Metabolic Inflammatomentioning

confidence: 97%

How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review

Faienza

Lassandro

Chiarito

et al. 2020

IJERPH

Self Cite

View full text Add to dashboard Cite

Bone remodeling is a lifelong process, due to the balanced activity of the osteoblasts (OBs), the bone-forming cells, and osteoclasts (OCs), the bone-resorbing cells. This equilibrium is mainly regulated by the WNT-ß-cathenin pathway and the RANK-RANKL/OPG system, respectively. Bone ageing is a process which normally occurs during life due to the imbalance between bone formation and bone resorption, potentially leading to osteoporosis. Bone loss associated with bone ageing is determined by oxidative stress, the result of the increasing production of reactive oxygen species (ROS). The promotion of physical exercise during growth increases the chances of accruing bone and delaying the onset of osteoporosis. Several studies demonstrate that physical exercise is associated with higher bone mineral density and lower fracture incidence, and the resulting bone mineral gain is maintained with ageing, despite a reduction of physical activity in adulthood. The benefits of exercise are widely recognized, thus physical activity is considered the best non-pharmacologic treatment for pathologies such as osteoporosis, obesity, diabetes and cardiovascular disease. We reviewed the physiological mechanisms which control bone remodeling, the effects of physical activity on bone health, and studies on the impact of exercise in reducing bone ageing.

show abstract

High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes

Cited by 68 publications

References 42 publications

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Protective effect of Vitamin D on imidacloprid-induced testicular injury in rats

How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review

Contact Info

Product

Resources

About