High level of interleukin-10 in serum after therapy is characteristic of prostate carcinoma patients with high Gleason score, high tumor volume and present peritumoral infiltration

Abstract

Background/Aim. Recent data implicate at significance of certain cytokines in the appearance and development of CP, as well as their association with pathohistological and/or clinical characteristics of prostate cancer. The aim of our study was to examine the relationship between the IL-10 concentration with pathohistological and clinical disease characteristics of CP patients. Methods. IL-10 concentration was determined in serum, urine and pms samples of 88 CP patients (initially and after therapy), 20 BPH patients and 15 healthy controls. Results. Comparing to BPH and control groups, CP patients had the highest average sera IL-10 concentration. Interestingly, BPH patients demonstrated the highest concentration in urine and pms samples. Also, patients with G3 gradus and with the highest Gleason score (4+4) demonstrated the highest IL-10 sera level. CP patients without any patohistological sign of tumor invasion had significantly increased serum IL-10, either before or after therapy, comparing to patient group with evident invasion of tumor cells. Therapy induced different IL-10 profile in serum and urine samples. After therapy there was clear significant IL-10 increase in sera of patients of unfavorable Gleason score (4+4), with present infiltration of tumor cells in peritumor tissue (lymphatic, vascular and combined) and in patients with high tumor volumen. Conclusion. CP patients without any pathohistological signs of tumor invasion before therapy have significantly increased serum IL-10 concentration comparing to those with signs of tumor invasion. There is a clear dissociation of IL-10 value between a serum sample and local, urine and pms samples from particular patient. After therapy, high IL-10 sera concentration is present only in patients with high Gleason score, present infiltration of peritumor tissue and high tumor volume.