High levels and gender difference of exhaled nitric oxide in Chinese schoolchildren

Wong, Gary; Liu, E. K.H.; Leung, Ting Fan; Yung, Edmund; Ko, Fanny W.S.; Hui, David S.; Fok, Tai-fai; Lai, Ching‐Long

doi:10.1111/j.1365-2222.2005.02263.x

Cited by 74 publications

(62 citation statements)

References 27 publications

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“…This result is in agreement with the works of Barreto et al 4 and Wong et al, 16 who recently demonstrated a sex difference in eNO levels in schoolchildren. Similarly, Nordvall et al, 17 in a large population sample, found a significantly higher eNO in boys than in girls.…”

Section: Discussionsupporting

confidence: 93%

Factors that influence exhaled nitric oxide in Italian schoolchildren

Cibella

Cuttitta

Grutta³

et al. 2008

Annals of Allergy, Asthma & Immunology

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Background:Conflicting results exist about the meaning of exhaled nitric oxide (eNO) in epidemiologic studies, mainly because of the numerous factors that may affect the measurement.Objectives: To evaluate the role of the factors that influence eNO levels in a sample of schoolchildren with or without respiratory diseases. We studied 335 schoolchildren, ages 10 to 16 years, from 8 schools in Palermo, Italy. After a respiratory questionnaire was completed, spirometry, skin tests, and eNO measurements were performed.Results: Among 335 children, 13.7% reported symptoms of bronchial asthma, 46.9% reported symptoms of rhinitis, and 39.4% were asymptomatic. The ratio of forced expiratory volume in 1 second to forced vital capacity was 87.6% (SD, 6.4%) in the bronchial asthma group, 90.6% (SD, 5.0%) in the rhinitis group, and 90.4% (SD, 5.1%) in the asymptomatic group (P Ͻ .002). Atopic children constituted 52.2% of the bronchial asthma group, 40.1% of the rhinitis group, and 28.8% of the asymptomatic group. Among atopic children, 102 (82%) had a positive skin test result for Dermatophagoides. Median eNO was 12.6 ppb in nonatopic children and 21.2 ppb in atopic children (P Ͻ .001, by Mann-Whitney U test). Among asymptomatic children, atopic children had significantly higher eNO levels than did nonatopic children (P Ͻ .001). In nonatopic children, no difference was found in log transformation eNO among healthy, rhinitic, or asthmatic children. Log transformation eNO increased with the number of positive skin test results (P Ͻ .001). Atopy, asthma, male sex, and indoor allergens were predictors of increased eNO in a logistic model.Conclusions: Atopy (in particular, sensitization to indoor and perennial allergens) is strongly associated with higher eNO levels. Such association is enhanced by asthma.

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Section: Discussionsupporting

confidence: 93%

Factors that influence exhaled nitric oxide in Italian schoolchildren

Cibella

Cuttitta

Grutta³

et al. 2008

Annals of Allergy, Asthma & Immunology

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“…Table 4 summarises the comparison of FeNO of normal adults without known lung diseases between different populations. Compared with the study performed in Sweden by OLIN et al [14] with 1131 subjects, [28]. Another large-scale paediatric study in Canada involving 656 school children aged 9-12 years also found that AsianCanadian subjects had a higher FeNO value than white subjects and the African-Canadian subjects [12].…”

Section: Discussionmentioning

confidence: 67%

Determinants of, and reference equation for, exhaled nitric oxide in the Chinese population

Leung

Wong

et al. 2012

Eur Respir J

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Measurement of fractional exhaled nitric oxide concentration (FeNO) has been proposed as a useful biomarker for monitoring and management of airway diseases. Limited information is available regarding reference levels of FeNO levels in Chinese adults. This study aimed to investigate the reference equation and determinants of FeNO in Chinese adults.1093 (577 males) healthy nonsmoking subjects aged 18-90 years were recruited. FeNO was measured online using a chemiluminescence analyser. Other assessments included spirometry, skin prick tests, total serum IgE levels and eosinophil count in peripheral blood.The geometric mean FeNO was 32.6 (95% reference interval (RI) 31. log(FeNO) 5 0.781 + 0.104(sex) + 0.004(age) + 0.084(atopy) + 0.003(height in cm), where for sex 15male and 05female, age is measured in years, for atopy 15atopic and 05nonatopic, and height is measured in cm.The FeNO of Chinese adults is higher than that of the Caucasian population, and is affected by age, sex, height and atopic status. This study provides useful references for the interpretation of FeNO. @ERSpublications Exhaled NO fraction in Chinese adults is higher than in Caucasians, and is affected by age, sex, height and atopy

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“…Exhaled nitric oxide levels (a surrogate of eosinophilic inflammation) among obese asthmatic children may be the same or even reduced compared to similar leans. [134][135][136][137][138] A few studies in adult obese asthmatics have shown reduced eosinophilic inflammation compared with similar leans. 112,113 Obese asthmatic children did not have elevated airway LTB 4 .…”

Section: Airway Inflammationmentioning

confidence: 99%