High lipoprotein(a) levels predict severity of coronary artery disease in patients hospitalized for acute myocardial infarction. Data from the French RICO survey

Farnier, Michel; Chagué, F.; Maza, M.; Bichat, Florence; Masson, David; Cottin, Yves; Zeller, Marianne

doi:10.1016/j.jacl.2022.07.006

Cited by 10 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Lp(a)-lowering Treatmentmentioning

confidence: 99%

“…Converging evidence proclaims the role of Lp(a) in cardiovascular disease, including myocardial infarction, ischemic stroke and calcific aortic valve disease [ 237 , 238 ]. Its action seems to be mediated not only by its lipid-carrying content but mainly by its ability to carry and deliver oxidized phospholipids (OxPL) directly to tissue targets, which are converted to lysophosphatidic acid by autotaxin, infiltrate the endothelium and promote inflammation [ 238 , 239 ]. Data show the Lp(a)-lowering effect of new antilipidemic agents and establish Lp(a) as a potential new target for decreasing cardiovascular risk as lifestyle modifications are unlikely to have any effects on Lp(a) levels because of the primary genetic basis [ 240 , 241 , 242 ].…”

Section: Lp(a)-lowering Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment

et al. 2023

View full text Add to dashboard Cite

Lipoprotein(a) (Lp(a)) is a low-density lipoprotein (LDL) cholesterol-like particle bound to apolipoprotein(a). Increased Lp(a) levels are an independent, heritable causal risk factor for atherosclerotic cardiovascular disease (ASCVD) as they are largely determined by variations in the Lp(a) gene (LPA) locus encoding apo(a). Lp(a) is the preferential lipoprotein carrier for oxidized phospholipids (OxPL), and its role adversely affects vascular inflammation, atherosclerotic lesions, endothelial function and thrombogenicity, which pathophysiologically leads to cardiovascular (CV) events. Despite this crucial role of Lp(a), its measurement lacks a globally unified method, and, between different laboratories, results need standardization. Standard antilipidemic therapies, such as statins, fibrates and ezetimibe, have a mediocre effect on Lp(a) levels, although it is not yet clear whether such treatments can affect CV events and prognosis. This narrative review aims to summarize knowledge regarding the mechanisms mediating the effect of Lp(a) on inflammation, atherosclerosis and thrombosis and discuss current diagnostic and therapeutic potentials.

show abstract

Section: Lp(a)-lowering Treatmentmentioning

confidence: 99%

Section: Lp(a)-lowering Treatmentmentioning

confidence: 99%

Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…However, AMI patients need to complete continuous follow-ups to evaluate and improve their prognosis. Recently, the Gensini score and the SYNTAX score were used to predict the prognosis of AMI in clinics, but they could not be widely applied due to their complexity [ 3 – 5 ]. It was estimated that more than 50% of malnourished critically ill AMI patients admitted to the intensive care unit (ICU) could have more comorbidities and the risk of organ dysfunction [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

The prognostic nutritional index predicts all-cause mortality in critically ill patients with acute myocardial infarction

Huang

Zhang

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Malnutrition is common in patients with acute myocardial infarction (AMI) and is associated with a poor prognosis. The prognostic value of the prognostic nutritional index (PNI) in patients with AMI remains controversial. We aimed to explore the relationship between PNI and all-cause mortality in critically ill patients with AMI and evaluate the incremental prognostic value of PNI to commonly used prognostic assessment tools. Methods The Medical Information Mart for Intensive Care-IV (MIMIC-IV) database was used to conduct a retrospective cohort analysis on 1180 critically ill patients with AMI. The primary endpoints were defined as 6-month and 1-year all-cause mortality. Cox regression analysis was used to investigate the relationship between admission PNI and all-cause mortality. The effect of adding PNI to sequential organ failure assessment (SOFA) score, or charlson comorbidity index (CCI) on its discriminative ability was assessed using C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results Multivariate cox regression analysis demonstrated that the low PNI was regarded as an independent predictor of 1-year all-cause mortality in AMI patients admitted to ICU (adjusted Hazard Ratio: 95% CI = 1.75 (1.22–2.49)). The ROC test showed that admission PNI had a moderate predictive ability to predict all-cause mortality of critically ill patients with AMI. Furthermore, the net reclassification and integrated discrimination of the CCI alone model improved significantly with PNI. [C-statistic increased from 0.669 to 0.752, p < 0.001; NRI = 0.698, p < 0.001; IDI = 0.073, p < 0.001]. When PNI was added to the SOFA score, the C-statistic significantly improved from 0.770 to 0.805 (p < 0.001), and the NRI and IDI were estimated at 0.573 (p < 0.001) and 0.041 (p < 0.001), respectively. Conclusion PNI could be a novel predictor for identifying patients at high risk of 1-year all-cause mortality in critically ill patients with AMI. The addition of PNI to the SOFA score or CCI may be useful for very early risk stratification.

show abstract

Emerging Cardiovascular Risk Factors

Demeter,

Papp,

Weidner

2024

Preventive Cardiovascular Nursing

View full text Add to dashboard Cite

High lipoprotein(a) levels predict severity of coronary artery disease in patients hospitalized for acute myocardial infarction. Data from the French RICO survey

Cited by 10 publications

References 40 publications

Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment

Lipoprotein(a) in Atherosclerotic Diseases: From Pathophysiology to Diagnosis and Treatment

The prognostic nutritional index predicts all-cause mortality in critically ill patients with acute myocardial infarction

Emerging Cardiovascular Risk Factors

Contact Info

Product

Resources

About