High lovastatin production by Aspergillus terreus in solid-state fermentation on polyurethane foam: An artificial inert support

Baños, Jesús G.; Tomasini, Araceli; Szakács, George; Barrios-González, Javier

doi:10.1016/j.jbiosc.2009.03.006

Cited by 64 publications

(62 citation statements)

References 28 publications

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“…It has been reported that a concentrated medium adequate for SSF, such as 2.5 ! media formulation for submerged culture, is not convenient for secondary metabolites production in SmF [Baños et al, 2009;BarriosGonzález and Tomasini, 1996;Barrios-González et al, 1988]. In order to confirm if this statement applies to A. chrysogenum cultures, a SmF using 2.5 !…”

Section: Resultsmentioning

confidence: 99%

Solid-State and Submerged Fermentations Show Different Gene Expression Profiles in Cephalosporin C Production by Acremonium chrysogenum

et al. 2012

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Despite the importance of Acremonium chrysogenum as the only cephalosporin C (CPC) producer, there is still a limited understanding about the molecular mechanisms regulating antibiotic biosynthesis in this fungus. Based on the previously described relationship between environmental pH and antibiotic production in numerous filamentous fungi, we studied the expression of genes related to CPC production in A. chrysogenum. We report for the first time similarities and differences, characterizing CPC production by A. chrysogenum under a variable pH environment, in submerged and solid-state fermentation. This characterization is supported by measurements of parameters, like CPC production, pH, growth, and expression levels of several genes involved, directly or indirectly, in CPC production. Interesting differences in intermediate (Pen N) and certain biosynthetic gene expression levels were observed. Our results point out some relationships between physiological features and gene expression that open important improvement perspectives for both culture systems.

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Section: Resultsmentioning

confidence: 99%

Solid-State and Submerged Fermentations Show Different Gene Expression Profiles in Cephalosporin C Production by Acremonium chrysogenum

et al. 2012

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“…Nonagglomerative mechanism (agglomerates formed from an individual spore) is found in prokaryotic Streptomyces [47,51]. [26] Significance of A. terreus morphology (minimizing its variations) for lovastatin production in conjunction with mass transfer processes 2 Novak et al [52] Evidence that fed-batch process is more efficient for lovastatin production than the batch one provided the overfeeding is avoided 3 Kumar et al [38] Evidence that fed-batch process is more efficient for lovastatin production than the batch one; determination of k L a during lovastatin production 4 Liu et al [43] Morphologically structured model for lovastatin biosynthesis 5 Hajjaj et al [32] Starvation (lack of substrate) is required for lovastatin production 6 Lai et al [41] Oxygen vector (n-dodecane) increases lovastatin titre in shake flask culture, but not in the bioreactor, and changes fungal morphology 7…”

Section: Fungal Morphology and Lovastatin Formationmentioning

confidence: 99%

Bioprocess Engineering Aspects of the Cultivation of a Lovastatin Producer Aspergillus terreus

Bizukojć

Ledakowicz

2015

Advances in Biochemical Engineering/Biotechnology

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The aim of this work is to review bioprocess engineering aspects of lovastatin (antihypercholesterolemia drug) production by Aspergillus terreus in the submerged culture in the bioreactors of various scale presented in the scientific literature since the nineties of the twentieth century. The key factor influencing the cultivation of any filamentous species is fungal morphology and that is why this aspect was treated as the starting point for further considerations. Fungal morphology is known to have an impact on the following issues connected with the cultivation of A. terreus reviewed in this article. These are broth viscosity in conjunction with non-Newtonian behaviour of the cultivation broths, and multistage oxygen transfer processes: from gas phase (air) to liquid phase (broth) and diffusion in the fungal agglomerates. The latest achievements concerning the controlling A. terreus morphology during lovastatin biosynthesis with the use of morphological engineering techniques were also reviewed. Last but not least, some attention was paid to the type of a bioreactor, its operational mode and kinetic modelling of lovastatin production by A. terreus.

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“…Among the products of significance, many fungal sub-or by-products are listed, such as enzymes, natural drugs, and nutraceuticals (Moore and Chiu 2001;Couto and Sanromán 2005;Ghorai et al 2009;Baños et al 2009). These additives can be obtained by either specific extraction or concentration, used primarily by the industrialized sector, or by the utilization of whole organisms or parts of their recovered biomass.…”

Section: Preservation Of Fungal Materialsmentioning

confidence: 99%

“…For many of the biotechnological fungal products of interest, such as enzymes and secondary metabolites, SSF has been chosen (Baños et al 2009;Saqib et al 2010). This substrate promotes best growing conditions for the fungi as well as specific stability for the compounds they produce (Couto and Sanromán 2006;Singhania et al 2009).…”

Section: Preservation Of Fungal Materialsmentioning

confidence: 99%

“…This fungus has been properly adapted to grow in liquid substrates, with several studies proposing its experimental optimization in SmF for the production of mycelial biomass and exopolysaccharides (Lin and Yang 2006;Fan et al 2007;Hamedi et al 2007). Examples of experimental optimization for several fungal species in SSF for the production of industrially important products have been proposed (Prakash et al 2008;Baños et al 2009). However, for A. subrufescens, few are the citations that report the use of SSF, due probably to the barriers inherent to this methodology (Dalla-Santa et al 2011;Camelini et al 2013a).…”

Section: Preservation Of Fungal Materialsmentioning

confidence: 99%

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Fungal Cultivation and Production of Polysaccharides

Camelini¹,

Rossi²,

Cardozo³

et al. 2014

Polysaccharides

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Many species of higher basidiomycetes have traditionally been used because of their medicinal properties. The positive effects associated to the consumption of those fungi have been mainly attributed to cell wall polysaccharides, which have important structural roles and are present throughout the entire life cycles of fungi. One of the most consumed and studied species native of the Americas is Agaricus subrufescens, a mushroom prescribed in different countries for prophylaxis and noninvasive treatment of numerous health-related disorders. Prior to the process of extraction, purification, and application of these polysaccharides, one needs to be concerned with the preservation of the specimen and production of fungal biomass. Even though basidiomata (syn. fruiting bodies, mushrooms) generally yield larger volumes of biomass when compared to the mycelium, cultivation of mycelium allows a more efficient control of the process and, therefore, is the method of choice of polysaccharide production. Mycelial biomass can be produced by solid-state fermentation (SSF) or submersed fermentation (SmF). Further separation and concentration of bioactive polysaccharides can be done by means of porous membranes, such as tangential flow nanofiltration.

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High lovastatin production by Aspergillus terreus in solid-state fermentation on polyurethane foam: An artificial inert support

Cited by 64 publications

References 28 publications

Solid-State and Submerged Fermentations Show Different Gene Expression Profiles in Cephalosporin C Production by <b><i>Acremonium chrysogenum</i></b>

Solid-State and Submerged Fermentations Show Different Gene Expression Profiles in Cephalosporin C Production by <b><i>Acremonium chrysogenum</i></b>

Bioprocess Engineering Aspects of the Cultivation of a Lovastatin Producer Aspergillus terreus

Fungal Cultivation and Production of Polysaccharides

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