High miR-31-5p expression promotes colon adenocarcinoma progression by targeting TNS1

Mi, Bobin; Li, Qiushi; Li, Tong; Liu, Guohui; Sai, Jiayang

doi:10.18632/aging.103096

Cited by 31 publications

(27 citation statements)

References 46 publications

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“…miR-31 acts as a promoter of cell proliferation, invasion, and migration in vitro and tumorigenesis and metastasis in CRC [ 39 ]. It is reported to be overexpressed in CRC tissues compared to normal tissues [ 40 ]. Similar to our results in plasma, it is also upregulated in serum of CRC patients [ 41 ] where it exhibits along with miR-146a-5p, and miR-148a-3p strong diagnostic ability [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNA as Biomarkers for Colorectal Cancer Diagnosis and Liver Metastasis

et al. 2021

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Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. Stage IV CRC patients have poor prognosis with a five-year survival rate of 14%. Liver metastasis is the main cause of mortality in CRC patients. Since current screening tests have several drawbacks, effective stable non-invasive biomarkers such as microRNA (miRNA) are needed. We aim to investigate the expression of miRNA (miR-21, miR-19a, miR-23a, miR-29a, miR-145, miR-203, miR-155, miR-210, miR-31, and miR-345) in the plasma of 62 Lebanese Stage IV CRC patients and 44 healthy subjects using RT-qPCR, as well as to evaluate their potential for diagnosis of advanced CRC and its liver metastasis using the Receiver Operating Characteristics (ROC) curve. miR-21, miR-145, miR-203, miR-155, miR-210, miR-31, and miR-345 were significantly upregulated in the plasma of surgery naïve CRC patients when compared to healthy individuals. We identified two panels of miRNA that could be used for diagnosis of Stage IV CRC (miR-21 and miR-210) with an area under the curve (AUC) of 0.731 and diagnostic accuracy of 69% and liver metastasis (miR-210 and miR-203) with an AUC = 0.833 and diagnostic accuracy of 72%. Panels of specific circulating miRNA, which require further validation, could be potential non-invasive diagnostic biomarkers for CRC and liver metastasis.

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Section: Discussionmentioning

confidence: 99%

Circulating miRNA as Biomarkers for Colorectal Cancer Diagnosis and Liver Metastasis

et al. 2021

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“…Those who were unresponsive downregulated it [25]. [23].  Additionally, miR-31 knockdown worsened inflammation in a mouse inflammatory bowel disease model [24].…”

Section: Sars-cov-2 Infected mentioning

confidence: 99%

“…miR-146a-5p was also found to downregulate IL-1β and IRAK1 expression [27]. [ [23].  Additionally, miR-31 knockdown worsened inflammation in a mouse inflammatory bowel disease model [24].…”

Section: Sars-cov-2 Infected mentioning

confidence: 99%

“…However, miR-29-3p was thought to promote IL-8 and other cytokine expression in a mouse respiratory disease model [41]. However, miR-31 is also associated with TNS1 downregulation, an enhancer of immune infiltration [23].  Additionally, miR-31 knockdown worsened inflammation in a mouse inflammatory bowel disease model [24].…”

Section: Sars-cov-2 Infected Nhbe Cells (Bronchial)mentioning

confidence: 99%

“… PVT1 was also upregulated in the synovial tissue of arthritis patients [30]. [ [23].  Additionally, miR-31 knockdown worsened inflammation in a mouse inflammatory bowel disease model [24].…”

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confidence: 99%

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Non-Coding RNAs in COVID-19: Emerging Insights and Current Questions

Plowman

Lagos

2021

ncRNA

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The highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the causative agent of coronavirus disease 2019 (COVID-19) in late 2019, igniting an unprecedented pandemic. A mechanistic picture characterising the acute immunopathological disease in severe COVID-19 is developing. Non-coding RNAs (ncRNAs) constitute the transcribed but un-translated portion of the genome and, until recent decades, have been undiscovered or overlooked. A growing body of research continues to demonstrate their interconnected involvement in the immune response to SARS-CoV-2 and COVID-19 development by regulating several of its pathological hallmarks: cytokine storm syndrome, haemostatic alterations, immune cell recruitment, and vascular dysregulation. There is also keen interest in exploring the possibility of host–virus RNA–RNA and RNA–RBP interactions. Here, we discuss and evaluate evidence demonstrating the involvement of short and long ncRNAs in COVID-19 and use this information to propose hypotheses for future mechanistic and clinical studies.

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Development of a miRNA‐based classifier for detection of colorectal cancer molecular subtypes

Adam

Poel²,

Moreno

et al. 2022

Molecular Oncology

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Previously, colorectal cancer (CRC) has been classified into four distinct molecular subtypes based on transcriptome data. These consensus molecular subtypes (CMSs) have implications for our understanding of tumor heterogeneity and the prognosis of patients. So far, this classification has been based on the use of messenger RNAs (mRNAs), although microRNAs (miRNAs) have also been shown to play a role in tumor heterogeneity and biological differences between CMSs. In contrast to mRNAs, miRNAs have a smaller size and increased stability, facilitating their detection. Therefore, we built a miRNA‐based CMS classifier by converting the existing mRNA‐based CMS classification using machine learning (training dataset of n = 271). The performance of this miRNA‐assigned CMS classifier (CMS‐miRaCl) was evaluated in several datasets, achieving an overall accuracy of ~ 0.72 (0.6329–0.7987) in the largest dataset (n = 158). To gain insight into the biological relevance of CMS‐miRaCl, we evaluated the most important features in the classifier. We found that miRNAs previously reported to be relevant in microsatellite‐instable CRCs or Wnt signaling were important features for CMS‐miRaCl. Following further studies to validate its robustness, this miRNA‐based alternative might simplify the implementation of CMS classification in clinical workflows.

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High miR-31-5p expression promotes colon adenocarcinoma progression by targeting TNS1

Cited by 31 publications

References 46 publications

Circulating miRNA as Biomarkers for Colorectal Cancer Diagnosis and Liver Metastasis

Circulating miRNA as Biomarkers for Colorectal Cancer Diagnosis and Liver Metastasis

Non-Coding RNAs in COVID-19: Emerging Insights and Current Questions

Development of a miRNA‐based classifier for detection of colorectal cancer molecular subtypes

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