High Molecular Weight Adiponectin as a Predictor of Long-Term Clinical Outcome in Patients With Coronary Artery Disease

Inoue, Teruo; Kotooka, Norihiko; Morooka, Toshifumi; Komoda, Hiroshi; Uchida, Toshihiko; Aso, Yoshimasa; Iwamoto, Toshihiko; Okuno, Takehiko; Node, Koichi

doi:10.1016/j.amjcard.2007.03.062

Cited by 114 publications

(87 citation statements)

References 23 publications

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“…29,30 However, cohort studies have not shown a clearer relationship between levels of high-molecular-weight adiponectin and CHD risk, two studies reporting no association, 25,31 and one showing a protective effect. 32 On the other hand, all studies, including the present one, have reported associations of levels of total or high-molecular-weight adiponectin with the main characteristics of the insulinresistance syndrome such as weight and visceral adipose mass, triglycerides and HDL cholesterol. [33][34][35][36] Clinical and cell cultures studies also describe other mechanisms for a high level of adiponectin such as a favorable effect on lipoprotein size 37 and a reduced lipid accumulation in Prospective epidemiological study of myocardial infarction G Luc et al macrophages, 38 both effects which would be responsible for decreased CHD risk.…”

Section: Discussionmentioning

confidence: 90%

Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study

et al. 2009

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Background: Adipokines play an important role in glucose, lipid and lipoprotein metabolisms, as well as in coagulation and inflammatory processes. So far, studies have evaluated the association of individual adipokines with future coronary heart disease (CHD) event and provided mixed results. Objectives: We sought to investigate the association of a set of adipocytokines, including total adiponectin, adipsin, resistin, leptin and plasminogen activator inihibitor-1 (PAI-1), with future CHD events in apparently healthy men. Methods: We built a nested case-control study within the PRIME Study, a multicenter prospective cohort of 9779 healthy European middle-aged men. Total adiponectin, adipsin, resistin, leptin and PAI-1 were measured in the baseline plasma sample of 617 men who developed a first CHD event (coronary death, myocardial infarction, stable or unstable angina) during 10 years of follow-up and in 1215 study-matched controls, by multiplex assays using commercial kits. HRs for CHD were estimated by conditional logistic regression analysis. Results: Median concentrations of total adiponectin, adipsin and resistin were similar in cases and in controls, whereas those of leptin and PAI-1 were higher in cases than in controls, 6.30 vs 5.40 ng ml À1 , and 10.09 vs 8.48 IU ml À1 , respectively. The risk of future CHD event increased with increasing quintiles of baseline leptin and PAI-1 concentrations only in unadjusted analysis (P-value for trend o0.003 and o0.0001, respectively). However, these associations were no longer significant after adjustment for usual CHD risk factors including hypertension, diabetes, smoking, total cholesterol, triglycerides and HDL cholesterol. Conversely, baseline CRP and IL-6 levels remained associated with CHD risk in multivariate analysis. Conclusions: In apparently healthy men, circulating total adiponectin, adipsin, resistin, leptin and PAI-1 were not independent predictors of future CHD event.

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Section: Discussionmentioning

confidence: 90%

Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study

et al. 2009

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“…Recently, longitudinal data concerning HMW adiponectin have been reported. For example, a decreased HMW adiponectin level was found to be an independent risk factor for progression to type 2 diabetes in Japanese Americans during a 5.4-year followup study 24) , and Inoue et al reported that the serum HMW adiponectin level was a predictor of cardiovascular events in patients with CAD during a 7-year follow-up study 25) .…”

Section: What Is Adiponectin?mentioning

confidence: 99%

Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders

Hara

Yamamoto

Seino-Yoshihara

et al. 2010

JAT

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In 1996, adiponectin was reported to be the most abundant transcript in adipose tissue. Animal studies revealed that administering adiponectin improves insulin resistance and blood glucose levels and inhibits atherosclerosis. In the present article, we review the significance of measuring serum high-molecular-weight (HMW) adiponectin levels in human subjects.Our cross-sectional studies revealed that the serum HMW adiponectin concentration was 1.9 times higher in healthy Japanese females than males and had a strong positive correlation with HDLcholesterol but a negative correlation with BMI and the homeostasis model assessment insulin resistance index (HOMA-IR). They also indicated that the serum HMW adiponectin concentration had a stronger association with HOMA-IR and metabolic syndrome than the total adiponectin concentration.Our longitudinal study, a 6-year follow-up of Japanese men, suggested that a decreased level of HMW adiponectin is a predictor of progression to metabolic syndrome. In another intervention study, lifestyle modification for 3 months induced a decrease in BMI and waist circumference and an increase in serum HMW adiponectin but not the total adiponectin level in 16 Japanese males with metabolic syndrome.Administering thiazolidinediones to diabetic patients increased the serum HMW adiponectin concentration 3 fold and improved glucose and lipid profiles and blood pressure. Some people may inherit a lower serum concentration of adiponectin, and have a higher risk of developing cardiovascular diseases.It is suggested that HMW adiponectin is a useful marker for the evaluation and care of subjects with metabolic syndrome and related disorders.

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“…Recently, a novel sandwich enzyme-linked immunosorbent assay (ELISA) kit has been developed that accurately determines serum HMW adiponectin levels without requiring any sample pretreatment 13) . Although there is evidence that HMW adiponectin levels measured by this method are decreased in patients with type 2 diabetes 14) and coronary artery disease 15) , clinical data on HMW adiponectin levels are still insufficient. This study was…”

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confidence: 99%

Association between High Molecular Weight Adiponectin Levels and Metabolic Parameters

Fujimatsu

Kotooka

Inoue

et al. 2009

JAT

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Aim: Low plasma adiponectin levels have been demonstrated to be linked to obesity and insulin resistance. It has also been suggested that high molecular weight (HMW) adiponectin is more important for vascular protection than the total amount of adiponectin, although clinical data of HMW adiponectin are lacking. The purpose of this study was to investigate HMW adiponectin levels in Japanese rural residents and to elucidate their clinical significance. Methods: We measured plasma HMW adiponectin levels in 1,183 subjects (643 men) who participated in our annual health check program in Kashima-city, Saga, Japan. Results: The median plasma level of HMW adiponectin was significantly lower in men than women (2.6, 1.6 − 4.0 vs 6.5, 3.7 − 8.6 g/mL, p 0.001), respectively. Multivariate linear regression analysis showed that body weight, B-type natriuretic peptide (BNP) and high density lipoprotein cholesterol were independently associated with HMW adiponectin in both genders. Triglyceride and serum creatinine levels were associated with HMW adiponectin in men only. Conclusions: HMW adiponectin levels were lower in men than in women and were associated with BNP independently. A prospective follow-up of the subjects in this study is required to determine the usefulness of HMW adiponectin as a biomarker for predicting the development of cardiovascular disease. J Atheroscler

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High Molecular Weight Adiponectin as a Predictor of Long-Term Clinical Outcome in Patients With Coronary Artery Disease

Cited by 114 publications

References 23 publications

Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study

Adipocytokines and the risk of coronary heart disease in healthy middle aged men: the PRIME Study

Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders

Association between High Molecular Weight Adiponectin Levels and Metabolic Parameters

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