High myopia and glaucoma: color Doppler imaging of the optic nerve vasculature

Montanari, P.; Marangoni, P; Pinotti, D.; Sinigaglia, Luigi; Ratiglia, Roberto; Raiteri, M.; Berardinelli, L

doi:10.1111/j.1600-0420.1999.tb01143.x

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Dimitrova, et al 78 established a negative correlation (r = -0.34, p = 0.013) between AL and resistance index (RI), indicating longer eyes had lower vascular resistance. Their findings were contradictory to other studies, 73,75 which might be due to the characteristics of their subjects, who had a wide range of refractive errors (-22.0 to +4.3D) and age (23 to 78 years).…”

Section: Myopia-related Hemodynamic Changes In Ocular Vasculaturecontrasting

confidence: 73%

“…The findings with respect to PCA were also diverse. A slower PCA flow 72,74 and a higher RI 72,75 in high myopes were reported in some studies, while others 73,77 found no significant difference between high myopes and emmetropes in any PCA parameter. Dimitrova, et al 78 identified a significant positive correlation between PCA velocities and SE, but the correlation between PCA velocity and AL was not significant.…”

Section: Myopia-related Hemodynamic Changes In Ocular Vasculaturementioning

confidence: 79%

“…Several studies have revealed decreased CRA flow velocities [72][73][74] and elevated vascular resistance 73,75 were recorded in high myopes and impaired CRA hemodynamics were associated with increased severity of myopic degenerative changes, 76 in contrast, Galassi, et al 77 did not detect any difference in CRA parameters between high myopes and nonmyopic controls. Dimitrova, et al 78 established a negative correlation (r = -0.34, p = 0.013) between AL and resistance index (RI), indicating longer eyes had lower vascular resistance.…”

Section: Myopia-related Hemodynamic Changes In Ocular Vasculaturementioning

confidence: 99%

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Structural and haemodynamic properties of ocular vasculature in axial myopia

Zhao

Lam

Cheong

2021

Clinical and Experimental Optometry

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The high prevalence of myopia has become a global concern, especially in East and Southeast Asia. Alarmingly, prevalence of high myopia is increasing. Mechanical stretching caused by excessive eyeball elongation leads to various anatomical changes in the fundus. This stretching force may also lead to the development of vascular abnormalities, which tend to be subtle and easily overlooked. A healthy ocular vasculature is a prerequisite of adequate oxygen supply for normal retinal functions. This review summarizes previous findings on structural and hemodynamic aspects of myopiarelated vascular changes.

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Section: Myopia-related Hemodynamic Changes In Ocular Vasculaturecontrasting

confidence: 73%

Section: Myopia-related Hemodynamic Changes In Ocular Vasculaturementioning

confidence: 79%

Section: Myopia-related Hemodynamic Changes In Ocular Vasculaturementioning

confidence: 99%

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Structural and haemodynamic properties of ocular vasculature in axial myopia

Zhao

Lam

Cheong

2021

Clinical and Experimental Optometry

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“…Myopia-related vascular changes occur to the retrobulbar CRA and its intraretinal branches. In the retrobulbar segment, color Doppler ultrasound, a commonly used technique for examining the retrobulbar circulation, disclosed impaired CRA hemodynamics in highly myopic eyes, as reflected by reduced blood flow velocities 14 – 17 and increased vascular resistance 15 , 18 . The compromised CRA hemodynamics have been associated with increased severity of myopic degenerative changes 19 .…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic and morphological changes of the central retinal artery in myopic eyes

Zhao

Lam

Ying

et al. 2022

Sci Rep

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Due to excessive elongation of the eyeball, myopia-related vascular abnormalities are frequently observed in the central retinal artery (CRA) and its intraretinal branches. In addition to inconsistency in previously reported findings, hemodynamic (reduced flow velocity, increased vascular resistance) and morphological changes (narrower vessel diameter) were usually studied separately. This cross-sectional study evaluated the hemodynamic and morphological characteristics concurrently in a large sample of healthy myopes, by using the color Doppler ultrasound and adaptive optics retinal camera. Results showed that the retrobulbar segment of CRA had a tendency of slightly reduced flow velocity in eyeballs with longer axial length, but the correlation was not significant after adjusting for the multiple correlations. Vascular resistance was not affected by the axial elongation. With respect to the intraretinal branches, no significant changes in longer eyes of total diameter or lumen diameter were observed, while both the wall thickness and the wall cross-sectional area were significantly increased, but only a marginally increase in the wall to lumen ratio was found with increasing axial length. This implies some potential small artery remodeling in the intraretinal CRA branches. Overall, blood supply of the inner retina in healthy young myopes is likely to be maintained. Additionally, morphological parameters of vascular microstructure could be potential biomarkers to monitor myopia progression and understand myopia-related vascular abnormalities in future studies.

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Modern Diagnostic Techniques for the Assessment of Ocular Blood Flow in Myopia: Current State of Knowledge

Grudzińska

Modrzejewska

2018

Journal of Ophthalmology

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Myopia is the most common refractive error and the subject of interest of various studies assessing ocular blood flow. Increasing refractive error and axial elongation of the eye result in the stretching and thinning of the scleral, choroid, and retinal tissues and the decrease in retinal vessel diameter, disturbing ocular blood flow. Local and systemic factors known to change ocular blood flow include glaucoma, medications and fluctuations in intraocular pressure, and metabolic parameters. Techniques and tools assessing ocular blood flow include, among others, laser Doppler flowmetry (LDF), retinal function imager (RFI), laser speckle contrast imaging (LSCI), magnetic resonance imaging (MRI), optical coherence tomography angiography (OCTA), pulsatile ocular blood flowmeter (POBF), fundus pulsation amplitude (FPA), colour Doppler imaging (CDI), and Doppler optical coherence tomography (DOCT). Many researchers consistently reported lower blood flow parameters in myopic eyes regardless of the used diagnostic method. It is unclear whether this is a primary change that causes secondary thinning of ocular tissues or quite the opposite; that is, the mechanical stretching of the eye wall reduces its thickness and causes a secondary lower demand of tissues for oxygen. This paper presents a review of studies assessing ocular blood flow in myopes.

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High myopia and glaucoma: color Doppler imaging of the optic nerve vasculature

Cited by 3 publications

References 3 publications

Structural and haemodynamic properties of ocular vasculature in axial myopia

Structural and haemodynamic properties of ocular vasculature in axial myopia

Hemodynamic and morphological changes of the central retinal artery in myopic eyes

Modern Diagnostic Techniques for the Assessment of Ocular Blood Flow in Myopia: Current State of Knowledge

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