High NF-κB and STAT3 activity in human urothelial carcinoma: a pilot study

Abstract

NF-κB and STAT3 signaling pathways, as main inflammatory mediators, are found to be activated in urothelial bladder carcinoma indicating that chronic inflammatory processes are accompanying development of this tumor type. Future studies will have to determine possible causative role of inflammatory processes in development of urothelial bladder carcinomas.

STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy

“…It has been observed that expression level of STAT3 correlates with invasion and poor prognosis in bladder cancer [17][18][19]44]. However, other groups could not confirm the prognostic value of STAT3 expression level [14]. We analysed molecular alterations in JAK/STAT proteins in the TCGA dataset including 412 patient specimens of muscle invasive bladder cancer.…”

“…Activation of JAK-STAT signalling, mostly by phosphorylation and protein level of STAT3/5 has been described in bladder cancer by several groups [14,15,20,43,44]. We wanted to specifically focus on involvement of JAK-STAT proteins as prognostic marker and also as potential targets for therapy.…”

“…STAT3, in particular, plays a role in cell cycle regulation, cytokine signalling and apoptosis. Increased protein level and constitutive activation of STAT3 have also been reported in bladder cancer [13][14][15][16][17]. Elevated and increased nuclear level of STAT3 and p-STAT3 have been reported to be associated with invasiveness of the disease and advanced stages of the cancer [13,[17][18][19][20][21].…”

“…The JAK-STAT pathway is one of the most studied pathways in cellular signal transduction with diverse roles in physiological processes including cell growth and differentiation and immune response via cytokine signalling [9]. Dysregulations in this pathway are implicated in carcinogenesis and are also associated with poor prognosis in various cancers including kidney cancer [10], lung cancer [11], cervical cancer [12] and bladder cancer [13,14]. The JAK (Janus Kinase) protein family consists of JAK1-3 and Tyk2 in mammals.…”

Tissue Profile of CDK4 and STAT3 as Possible Innovative Therapeutic Targets in Urinary Bladder Cancer

“…The relation between inflammation and cancer progression has been well established (Yu et al, 2009) has reported that STAT3 is the major inflammation-promoting transcription factor shown to play important roles in cancer progression in various types of tumors. Several studies have reported STAT3 as an important factor in the development of bladder cancer (Degoricija et al, 2014).…”