High nuclearity nickel compounds with three, four or five metal atoms showing antibacterial activity

Alexiou, Maria; Tsivikas, I.; Dendrinou‐Samara, Catherine; Pantazaki, Αnastasia A.; Trikalitis, Pantelis N.; Lalioti, Nikolia; Kyriakidis, D.A.; Kessissoglou, Dimitris P.

doi:10.1016/s0162-0134(02)00591-3

Cited by 118 publications

(67 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[4][5][6][7][8][9][10][11][12][13][14][15][16] Hydrazone ligands create an environment similar to the one present in biological systems usually by making coordination through oxygen and nitrogen atoms. Various important properties of carbonic acid hydrazides, along with their applications in medicine and analytical chemistry, have led to increased interest in their complexation characteristics with transition metal ions.…”

Section: Introductionmentioning

confidence: 99%

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

et al. 2012

View full text Add to dashboard Cite

3 )] (6). Structural characterization of these compounds 4-6 were accomplished by using various physico-chemical techniques. Single crystal X-ray diffraction data of complexes 4 and 5 proved their distorted square planar geometry. In order to ascertain the potential of the above synthesised compounds towards biomolecular interactions, additional experiments involving interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were carried out. All the ligands and corresponding nickel(II) chelates have been screened for their scavenging effect towards O 2 − , OH and NO radicals. The efficiency of complexes 4-6 to arrest the growth of HeLa, HepG-2 and A431 tumour cell lines has been studied along with the cell viability test against the non-cancerous NIH 3T3 cells under in vitro conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

et al. 2012

View full text Add to dashboard Cite

show abstract

“…32 In this work, the first factor is the main factor. 2 (DMF)(CH 3 OH)) with the low MIC value (12 -25 μg/mL), 33 the MIC value of compound 2 is much higher. Based on these data, it is still not ready to correlate the nuclear and ligand numbers to the antibacterial activity.…”

Section: Antibacterial Activitiesmentioning

confidence: 99%

Synthesis, Crystal Structure and Bioactivities of a Novel Propeller Shaped Manganese Complex with the Ligand N′‐Benzylidenesalicylhydrazide

Sun

Cheng

et al. 2009

Chin. J. Chem.

View full text Add to dashboard Cite

A new propeller shaped mononuclear manganese(III) complex of the general formula: [MnL 3 (H 2 O)], where HL is N'-benzylidenesalicylhydrazide, was synthesized and characterized. The crystal structure of the title compound was characterized by X-ray single crystal diffractometry, which belongs to a triclinic system with space group P-1, cell dimensions of a＝11.6411 Å, b＝12.728 Å, c＝16.346 Å, α＝110.357°, β＝96.555°, γ＝108.996°, V＝2075.2 Å 3 , Z＝2 and D calc ＝1.265 g/cm 3 . In this complex, the metal ion is in an octahedral coordination environment, enforcing the stereochemistry of the ligands as a propeller configuration. Antibacterial screening data indicate that the complex has stronger antibacterial activity against the tested microorganisms than the ligand.

show abstract

“…Cultures for Gram (+ve) and Gram (-ve) were incubated at 37°C. A control test with no active ingredient was also performed [22]. The MIC was determined using two-fold serial dilutions in liquid media containing a 0.2-3,500 µM variation of the test compound concentration.…”

Section: In-vitro Antimicrobial Screeningmentioning

confidence: 99%

“…The binding of DNA via the intercalation mode usually results in hypochromism and bathchromism [22][23][24][25][26], because the intercalation mode involves a strong stacking interaction between an aromatic chromophore and the DNA base pair [27]. With the selection of the appropriate absorbance peak, spectrophotometric wavelength scans of each Cu(II) complexes were performed.…”

Section: Absorbance Titration Experimentsmentioning

confidence: 99%

Third generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA–interaction approach

Patel

Parmar

Gandhi

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

High nuclearity nickel compounds with three, four or five metal atoms showing antibacterial activity

Cited by 118 publications

References 49 publications

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

Variation in the biomolecular interactions of nickel(ii) hydrazone complexes upon tuning the hydrazide fragment

Synthesis, Crystal Structure and Bioactivities of a Novel Propeller Shaped Manganese Complex with the Ligand N′‐Benzylidenesalicylhydrazide

Third generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA–interaction approach

Contact Info

Product

Resources

About