High Oral Vitamin D<sub>3</sub>Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice

Lerche, Catharina M.; Pinto, Fernanda E.; Philipsen, Peter Alshede; BECH, ELISABETH S.; Jakobsen, Jette; Hædersdal, Merete; Wulf, Hans Christian

doi:10.21873/anticanres.16017

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“…Mice in the control group showed no sign of tumours or pigmentation (Figure S1). These observations were in accordance with those of previous studies 31,32 …”

Section: Resultssupporting

confidence: 94%

Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR

Meyer,

Andersen,

Børsting

et al. 2024

Experimental Dermatology

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Squamous cell carcinoma (SCC) is a common skin cancer, often caused by exposure to ultraviolet radiation (UVR). Recent studies have shown that changes in DNA methylation play a crucial role in the development of cancers. However, methylation patterns of SCC are not well characterised. Identifying biomarkers for the risk of developing SCC could be helpful for early detection and diagnosis and can potentially improve treatment and prevention strategies. This study aimed to investigate methylation changes in the epidermis of mice exposed to UVR for 24 weeks. We examined the DNA methylation levels of 260 199 CpGs using the Illumina Infinium Mouse Methylation BeadChip and studied the epidermis of UVR‐exposed and unexposed mice every 4 weeks for 24 weeks (n = 39). We identified CpGs with large differences in methylation levels (β‐values) between UVR‐exposed and unexposed mice. We also observed differences in the epigenetic age of these mice. We identified CpGs in Rev, Ipmk, Rad51b, Fgfr2, Fgfr3 and Ctnnb1 that may serve as potential biomarkers for SCC risk and could be helpful for the early detection and prevention of SCC. Further investigations are necessary to determine the biological functions and clinical significance of these CpGs.

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“…Mice in the control group showed no sign of tumours or pigmentation (Figure S1). These observations were in accordance with those of previous studies 31,32 …”

Section: Resultssupporting

confidence: 94%

Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR

Meyer,

Andersen,

Børsting

et al. 2024

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

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High Oral Vitamin D₃Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice

Abstract: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Cited by 1 publication

References 24 publications

Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR

Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR

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High Oral Vitamin D3Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice

Abstract: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Cited by 1 publication

References 24 publications

Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR

Changes in mouse epidermal DNA methylation during development of squamous cell carcinoma in response to UVR

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High Oral Vitamin D₃Intake Does Not Protect Against UVR-induced Squamous Cell Carcinoma in Mice