High oxygen affinity hemoglobins

Mangin, O.

doi:10.1016/j.revmed.2016.06.003

Cited by 37 publications

(35 citation statements)

References 64 publications

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“…However, in those with symptoms for which the raised Hct may be contributory or if a previous thrombotic episode has occurred, or in individuals who are asymptomatic but who have affected family members with the same genetic lesion and a thrombotic episode, venesection to a target of 0·52 is suggested. This advice particularly pertains to those with high oxygen affinity haemoglobins (Mangin, ).…”

Section: Management Of Secondary Erythrocytosismentioning

confidence: 99%

A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis

et al. 2018

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Section: Management Of Secondary Erythrocytosismentioning

confidence: 99%

A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis

et al. 2018

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“…There exist also many case reports, which showed psychiatric disease symptoms in erythrocytosis. Apart from JAK2 ‐mutation associated polycythemia vera, erythrocytosis occurs in mutations of globin genes, which enhance oxygen affinity of Hb to supraphysiological levels (Mangin, 2016). These occurrences indicate that perturbations in Hb metabolism may associate with mental disorders.…”

Section: Background: New Evidence Suggest That Hemoglobins (Hbs) Are mentioning

confidence: 99%

Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects

Altinöz¹,

Ince

2017

Intl J of Devlp Neuroscience

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Hemoglobin (Hb) expression in the central nervous system is recently shown. Cooccurences of mental disorders (mainly bipolar disorder (BD) and tic disorders) with β- or α-thalassemia trait or erythrocytosis were witnessed, which may be due to peripheral or central hypoxia/hyperoxia or haplotypal gene interactions. β-Globin genes reside at 11p15.5 close to tyrosine hydroxylase, dopamine receptor DRD4 and Brain Derived Neurotrophic Factor, which involve in psychiatric diseases. α-Globin genes reside at 16p13.3 which associates with BD, tic disorders, ATR-16 Syndrome and Rubinstein Taybi Syndrome (RTS). CREB-Binding Protein (CEBBP)-gene is mutated in RTS, which commonly associates with mood disorders. 16p13.3 region also contains GRIN2A gene encoding N-methyl-d-aspartate receptor-2A and SSTR5 (Somatostatin Receptor-5), again involving in mental disorders. We demonstrated a protective role of minor HbA2 against post-partum episodes in BD and association of higher minor HbF (fetal hemoglobin) levels with family history of psychosis in a BD-patient cohort. HbA2 increases in cardiac ischemia and in mountain dwellers indicating its likely protection against ischemia/hypoxia. HMGIY, a repressive transcription factor of δ-globin chain of HbA2 is increased in lymphocytes of schizophrenics. In autism, deletional mutations were found in BCL11A gene, which cause persistence of HbF at high levels in adulthood. Also, certain polymorphisms in BCL11A strongly associate with schizophrenia. Further, many drugs from anabolic steroids to antimalarial agents elevate HbF and may cause mania. We ascribe a protective role to HbA2 and a maladaptive detrimental role to HbF in psychopathology. We believe that future studies on hemoglobins may pave to discover novel pathogenesis mechanisms in mental disorders.

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“…The P 50 value is the partial pressure of oxygen required to achieve 50% HGB saturation measured under the standard condition (whole blood with a normal level of 2,3-diphosphoglycerate (2,3-DPG), 37°C, pH 7.40), and the average P 50 is 26 ± 2 mmHg in the normal population of the plains [5]. However, we have no idea on whether P 50 could change during entering high-altitude environment.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the differences between the Tibetan and Han populations in the hemoglobin–oxygen affinity of red blood cells and in the adaptation to high-altitude environments

Liu

et al. 2017

Hematology

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High oxygen affinity hemoglobins

Cited by 37 publications

References 64 publications

A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis

A guideline for the management of specific situations in polycythaemia vera and secondary erythrocytosis

Hemoglobins emerging roles in mental disorders. Metabolical, genetical and immunological aspects

Investigation of the differences between the Tibetan and Han populations in the hemoglobin–oxygen affinity of red blood cells and in the adaptation to high-altitude environments

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