High Perceived Stress is Associated With Increased Risk of Ulcerative Colitis Clinical Flares

Sauk, Jenny; Ryu, Hyo Jin; Labus, Jennifer S.; Khandadash, Ariela; Ahdoot, Aaron I.; Lagishetty, Venu; Katzka, William; Wang, Hao; Naliboff, Bruce D.; Jacobs, Jonathan P.; Mayer, Emeran A.

doi:10.1016/j.cgh.2022.07.025

Cited by 21 publications

(6 citation statements)

References 39 publications

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“…This stress is due to new situations that face the pigs at the slaughterhouse, with various stressful stimuli such as strange sounds and mixing with unfamiliar pigs [ 17 ]. Previous reports have indicated that stress can increase faecal CALP in humans, suggesting that this increase could be related to the regulation of the immune system by stress [ 18 ], while other reports have associated these increases with the activation of inflammatory processes in the gut that occurs in stressful conditions [ 19 , 20 ]. The increases found in our study in the stress due to pre-slaughter lairage were lower than those found in sepsis, however further studies with other types of stress should be performed to evaluate if in some cases the increases could be high enough to mask a septic situation.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Calprotectin (S100A8/A9) in the Saliva of Pigs: Validation Data of A Commercially Available Automated Assay and Changes in Sepsis, Inflammation, and Stress

López-Martínez

Martı́nez-Subiela

Cerón

et al. 2023

Animals

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Calprotectin (CALP, S100A8/A9), also named myeloid-related protein 8/14, is a dimer complex of S100A8 and S100A9 that belongs to the S-100 protein family. It is involved in inflammation and has a wide range of proinflammatory functions, such as cytokine production and regulation of leukocyte adhesion, migration, and phagocytosis. In humans, CALP traditionally can be measured in faeces, serum, and saliva as a biomarker of inflammation and sepsis. The objective of this study was to validate an automated assay for CALP measurements in the saliva of pigs, having the advantage of the use of a non-invasive sample that is easy to collect. The assay was precise and accurate. CALP in saliva measured by this assay showed significant changes depending on the hour of the day. It also showed significant increases in the saliva of pigs after the administration of lipopolysaccharide (LPS), and showed a rise, although with increases of lower magnitude, after a stressful stimulus. Further studies should be made to gain knowledge about the possible practical applications of the measurements of CALP in the saliva of pigs as a biomarker to evaluate the animals’ health and welfare.

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Section: Discussionmentioning

confidence: 99%

Measurement of Calprotectin (S100A8/A9) in the Saliva of Pigs: Validation Data of A Commercially Available Automated Assay and Changes in Sepsis, Inflammation, and Stress

López-Martínez

Martı́nez-Subiela

Cerón

et al. 2023

Animals

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“…Taking into account the evolution of symptoms prior to and during flares may help to recognise a new flare in a patient with IBD. Moreover, asking about the presence of psychological factors such as anxiety, depression or stress is relevant, since these can increase the risk of a flare 9,10 . However, since the use of only patient reported outcome measurements (PROMs) has a low sensitivity to identify ongoing inflammation, in particular in CD, objectifiable diagnostic approaches should be used to prove or rule out ongoing active disease 11 .…”

Section: Guide To Making the Diagnosismentioning

confidence: 99%

Review article: A practical approach to persistent gastrointestinal symptoms in inflammatory bowel disease in remission

Aliu,

Bosch,

Keszthelyi

et al. 2024

Aliment Pharmacol Ther

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SummaryBackgroundPersistent gastrointestinal symptoms are prevalent in adult patients with inflammatory bowel disease (IBD), even when endoscopic remission is reached. These symptoms can have profound negative effects on the quality of life of affected patients and can be difficult to treat. They may be caused by IBD‐related complications or comorbid disorders, but they can also be explained by irritable bowel syndrome (IBS)‐like symptoms.AimsTo provide a practical step‐by‐step guide to diagnose and treat persistent gastrointestinal symptoms in patients with IBD in remission via a personalised approach.MethodsWe scrutinised relevant literature on causes, diagnostics and treatment of persistent gastrointestinal symptoms (abdominal pain or discomfort, bloating, abdominal distension, diarrhoea, constipation and faecal incontinence) in patients with IBD in remission.ResultsA graphical practical guide for several steps in diagnosing, identifying potential triggers and adequate treatment of persistent gastrointestinal symptoms in IBD in remission is provided based on supporting literature. The first part of this review focuses on the diagnostic and treatment approaches for potential IBD‐related complications and comorbidities. The second part describes the approach to IBS‐like symptoms in IBD in remission.ConclusionsPersistent gastrointestinal symptoms in IBD in remission can be traced back to potential pathophysiological mechanisms in individual patients and can be treated adequately. For both IBD‐related complications and comorbidities and IBS‐like symptoms in IBD in remission, pharmacological, dietary, lifestyle or psychological treatments can be effective. A systematic and personalised approach is required to reduce the burden for patients, healthcare systems, and society.

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“… 65 , 66 Only 3 observational studies have been conducted to investigate the bidirectional relationship of the brain–gut system in individuals with IBD. 67 , 68 , 69 Gracie et al 68 found an association of heightened baseline clinical disease activity and abnormal anxiety scores, although no such association was observed with depression scores. The second observational study showed a mutual relationship between perceived stress and symptoms.…”

Section: The Bgm System In Gastrointestinal and Metabolic Disordersmentioning

confidence: 99%

“…The second observational study showed a mutual relationship between perceived stress and symptoms. 67 In a longitudinal study, Sauk et al 69 found that increased perceived stress and associated increased tonic sympathetic nervous system activity was an independent risk factor for clinical IBD flares. As previously mentioned, recent research also showed that during states of inflammation in the gut, the PVB closes as a protective barrier, but in doing so increases the risk of anxiety-like behavior and cognitive deficits.…”

Section: The Bgm System In Gastrointestinal and Metabolic Disordersmentioning

confidence: 99%

Advances in Brain–Gut–Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications

Dong,

Mayer

2024

Cellular and Molecular Gastroenterology and Hepatology

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High Perceived Stress is Associated With Increased Risk of Ulcerative Colitis Clinical Flares

Cited by 21 publications

References 39 publications

Measurement of Calprotectin (S100A8/A9) in the Saliva of Pigs: Validation Data of A Commercially Available Automated Assay and Changes in Sepsis, Inflammation, and Stress

Measurement of Calprotectin (S100A8/A9) in the Saliva of Pigs: Validation Data of A Commercially Available Automated Assay and Changes in Sepsis, Inflammation, and Stress

Review article: A practical approach to persistent gastrointestinal symptoms in inflammatory bowel disease in remission

Advances in Brain–Gut–Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications

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