High-performance liquid chromatographic analysis for the determination of domperidone in human plasma

Kobylińska, Maria; Kobylińska, K

doi:10.1016/s0378-4347(00)00245-0

Cited by 45 publications

(36 citation statements)

References 5 publications

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“…This unique combination has comprehensive acid control and prokinetic action which ensures better control and relief from reflux, gastric ulcers, and associated gastrointestinal (GIT) disorders. Many methods like HPLC 4,5 , HPTLC 7 , and LCMS 9 [5][6][7][8][9] have been described in the literature for the determination of DOP and LAF individually or in combination with others. However, there is no spectroscopic method reported for the simultaneous determination of these drugs either as active pharmaceutical ingredient or from dosage forms.…”

Section: Lafutidine (Laf) Is (Furan-2-ylmethylsulphinyl)-n-[(z)-4-[4-mentioning

confidence: 99%

Simultaneous Estimation of Lafutidine and Domperidone by Ultraviolet Spectroscopy

Jadhav¹,

Dhamecha²,

Ghadlinge

et al. 2012

ISRN Analytical Chemistry

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A simple, accurate, and precise method for simultaneous estimation of Lafutidine and Domperidone in combined-dosage form have been described. The method employs formation and solving of simultaneous equations using 279 and 284 nm as two analytical wavelengths. This method allows the simultaneous determination of Lafutidine and Domperidone in concentration ranges employed for this purpose with the standard deviation of <1.0% in the assay of tablet.

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Section: Lafutidine (Laf) Is (Furan-2-ylmethylsulphinyl)-n-[(z)-4-[4-mentioning

confidence: 99%

Simultaneous Estimation of Lafutidine and Domperidone by Ultraviolet Spectroscopy

Jadhav¹,

Dhamecha²,

Ghadlinge

et al. 2012

ISRN Analytical Chemistry

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“…Différentes techniques permettant la détection et/ou la quantification des neuroleptiques dans le sang et les cheveux ont déjà été décrites, les plus sensibles employant la chromatographie en phase liquide couplée à la spectrométrie de masse (LC-MS/MS) [1][2][3][4][5]. En ce qui concerne les apparentés (méto-clopramide et dompéridone), des techniques ont également été publiées [6][7][8][9][10][11][12][13][14][15][16], mais aucune concentration capillaire de ces molécules n'a été rapportée à ce jour dans la littérature.…”

Section: Introductionunclassified

Recherche et dosage de quatre neuroleptiques et apparentés en LC-MS/MS dans les cheveux et les poils : à propos d’un cas pédiatrique

et al. 2011

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Résumé -Un enfant de 6 ans est hospitalisé en réanimation pédiatrique en raison d'une encéphalite d'aggravation rapide l'ayant mené dans le coma, sans diagnostic précis. Le quatrième jour, une recherche sanguine de toxiques ré-vèle la présence d'halopéridol et de rispéridone non prescrits a priori à l'enfant, à des concentrations thérapeutiques. Cinq mois plus tard, cet enfant est transféré pour rééducation à l'hôpital de Garches. Devant le contexte psychiatrique familial, les médecins évoquent la possibilité d'un syndrome de Münchausen par procuration. Une analyse de cheveux est demandée afin de confirmer l'éventuelle administration des deux neuroleptiques. Les cheveux étant relativement courts, un prélèvement de poils de jambe est également réalisé. L'halopéridol et la rispéridone n'ont pas été retrouvés en chromatographie liquide couplée à la spectrométrie de masse (CL-SM/SM) ni dans les cheveux ni dans les poils, ne permettant pas d'éclairer le diagnostic. En revanche, il a été retrouvé les molécules correspondant au traitement reçu durant l'hospitalisation. Ont ainsi été mis en évidence dans les deux segments de cheveux étudiés et les poils du métoclopramide ( Mots clés : Neuroleptiques, métoclopramide, dompéridone, cheveux, poils, syndrome de Münchausen, CL/SM/SM Abstract -We report here the case of a 6-year-old boy, hospitalized in a paediatric resuscitation service because of severe encephalitis which left him in a coma, without any specific diagnosis. Four days after his entry, a blood analysis of toxics was carried out and revealed haloperidol and risperidon at therapeutic concentrations. Months later, the boy was transferred for re-education to Garches Hospital. Knowing about the psychiatric familial context, doctors considered Münchausen syndrome by proxy. So, a hair analysis was requested in order to confirm the possible administration of these two neuroleptics. Analysis was carried out on hair samples and leg hair with liquid chromatography coupled with mass spectrometry (LC-MS/MS). Haloperidol and risperidon were not found, probably because sampling was too late. However, with a quantification method developed and validated on this occasion, we measured in two segments of the hair and in leg hair metoclopramid (301 and 210 pg/mg in hair, 799 pg/mg in leg hair) and domperidon (703 pg/mg, 1176 pg/mg and 108 pg/mg, respectively). Diazepam and its metabolites, nordiazepam and oxazepam, were also measured in hair (373 and 391 pg/mg, 271 and 249 pg/mg and 68 and 111 pg/mg, respectively), all these compounds reflecting the hospital treatment. We report here the first description of domperidon and metoclopramid concentrations in a Caucasian blond child's hair and leg hair in chronic therapeutic use.

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“…Several other analytical methods reported for quantitative determination of domperidone include spectrophotometry [3][4][5], high performance liquid chromatography [6][7][8][9][10][11], anodic differential pulse voltammetry [12], and titrimetry [13]. However, most of these methods require expensive and sophisticated instruments and are time consuming.…”

Section: Introductionmentioning

confidence: 99%

Novel potentiometric sensors for the selective determination of domperidone

2009

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The fabrication and electrochemical response characteristics of two novel potentiometric sensors for the selective determination of domperidone (DOM) are described. The two fabricated sensors incorporate DOM-PTA (phosphotungstic acid) ion pair as the electroactive material. The sensors include a PVC membrane sensor and a carbon paste sensor. The sensors showed a linear, stable, and near Nernstian slope of 56.5 and 57.8 mV/decade for PVC membrane and carbon paste sensors, respectively over a relatively wide range of DOM concentration (1.0 9 10 -1 -1.0 9 10 -5 and 1.0 9 10 -1 -3.55 9 10 -6 M). The response time of DOM-PTA membrane sensor was less than 25 s and that in the case of carbon paste sensor was less than 20 s. A useful pH range of 4-6 was obtained for both types of sensors. A detection limit of 7.36 9 10 -5 M was obtained for PVC membrane sensor and 1.0 9 10 -6 M was obtained for carbon paste sensor. The proposed sensors showed very good selectivity to DOM in the presence of a large number of other interfering ions. The analytical application of the developed sensors in the determination of the drug in pharmaceutical formulations such as tablets was investigated. The results obtained are in good agreement with the values obtained by the standard method. The sensors were also applied for the determination of DOM in real samples such as urine by the standard addition method.

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High-performance liquid chromatographic analysis for the determination of domperidone in human plasma

Cited by 45 publications

References 5 publications

Simultaneous Estimation of Lafutidine and Domperidone by Ultraviolet Spectroscopy

Simultaneous Estimation of Lafutidine and Domperidone by Ultraviolet Spectroscopy

Recherche et dosage de quatre neuroleptiques et apparentés en LC-MS/MS dans les cheveux et les poils : à propos d’un cas pédiatrique

Novel potentiometric sensors for the selective determination of domperidone

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