High-performance liquid chromatographic assay for the determination of sulfadoxine and N-acetyl sulfadoxine in plasma from patients infected with sensitive and resistant Plasmodium falciparum malaria

Dua, V. K.; Gupta, N. C.; Sethi, Prerana; Edwards, Glenn A.; Dash, A. P.

doi:10.1016/j.jchromb.2007.10.016

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…Neither sulphadoxine nor pyrimethine, nor their primary metabolites, are DCA [95,96], thus the mechanisms of secretion of these two drugs are not likely to involve OATs. Therefore, their pharmacokinetics would not be affected by probenecid.…”

Section: Introductionmentioning

confidence: 99%

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

Gutman

Kachur

Slutsker

et al. 2012

Malar J

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The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination.

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Section: Introductionmentioning

confidence: 99%

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

Gutman

Kachur

Slutsker

et al. 2012

Malar J

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“…Separations techniques such as HPLC or CE are still the most commonly used. Lots of HPLC methods were developed for the analysis of antimalarials in biological samples [] but, also for the quality control of medicines []. CE methods were essentially optimized for the analysis of antimalarials in biological samples [] and/or for separation of their isomers [].…”

Section: Introductionmentioning

confidence: 99%

Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting

et al. 2012

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Since antimalarial drugs counterfeiting is dramatically present on the African market, the development of simple analytical methods for their quality control is of great importance. This work consists in the CE analysis of 15 antimalarials (artesunate, artemether, amodiaquine, chloroquine, piperaquine, primaquine, quinine, cinchonine, mefloquine, halofantrine, sulfadoxine, sulfalen, atovaquone, proguanil, and pyrimethamine). Since all these molecules cannot be ionized at the same pH, MEKC was preferred because it also allows separation of neutral compounds. Preliminary experiments were first carried out to select the most crucial factors affecting the antimalarials separation. Several conditions were tested and four parameters as well as their investigation domain were chosen: pH (5-10), SDS concentration (20-90 mM), ACN proportion (10-40%), and temperature (20-35°C). Then, the experimental design methodology was used and a central composite design was selected. Mathematical modeling of the migration times allowed the prediction of optimal conditions (29°C, pH 6.6, 29 mM SDS, 36% ACN) regarding analyte separation. The prediction at this optimum was verified experimentally and led to the separation of 13 compounds within 8 min. Finally, the method was successfully applied to the quality control of African antimalarial medicines for their qualitative and quantitative content.

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Bioanalysis of antimalarials using liquid chromatography

Wahajuddin¹,

Raju²,

Taneja³

2013

TrAC Trends in Analytical Chemistry

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High-performance liquid chromatographic assay for the determination of sulfadoxine and N-acetyl sulfadoxine in plasma from patients infected with sensitive and resistant Plasmodium falciparum malaria

Cited by 8 publications

References 19 publications

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy

Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting

Bioanalysis of antimalarials using liquid chromatography

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