High-performance liquid chromatographic assay of fleroxacin in human serum using fluorescence detection

Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis

“…Hisep column can tolerate 16 ml of serum without significant loss of performance [136]. Hisep material was used for the direct analysis of endogenous compounds [137] and pharmaceuticals in biological matrices [101,135,136,[138][139][140][141][142][143][144].…”

Pharmacokinetics of fluoroquinolones in critical care patients: A bio-analytical HPLC method for the simultaneous quantification of ofloxacin, ciprofloxacin and moxifloxacin in human plasma

“…These molecules are weak heterocyclic amino acids with two reactive sites: an amino group which can be protonated and a carboxyl group which can lose a proton [7]. Due to this amphoteric character of fluoroquinolones, they may exist in cationic, neutral, zwitterionic and anionic forms.…”

“…However, in a wide interval of the pH scale, the molecules will, in an aqueous medium, be present in the ionic form. Careful adjustment of the pH of the mobile phase or adding an ion pair reagent may offer a solution [7].…”

Development of an Immunochromatographic Test Strip for Rapid Simultaneous Detection of Enrofloxacin and Ofloxacin in Tissue of Chicken Muscle and Pork

“…Enrofloxacin (ENR) and ofloxacin (OFL), two synthetic antibiotics of QNs with broadspectrum antibacterial activity, were developed exclusively for use in animals for therapy and prophylaxis and as growthpromoting additives (Brown 1996). Most of QNs (22-87 %) are excreted with active component (Djurdjevic et al 2001). Presently, several QNs are used for treatment of poultry and fish in many countries of the world (Watanabe et al 2002).…”