High performance liquid chromatographic determination of panthenol in bulk, premix and multivitamin preparations

Umagat, H.; Tscherne, R.

doi:10.1021/ac50058a052

Cited by 10 publications

(3 citation statements)

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“…(120) After conversion of the drug panthenol to aminopropanol, the fluorescamine reaction provided detection limits of 0.4 µg. (121) The determination of debrisoquine and its hydroxy metabolites was possible by reaction through the guanidine moiety to form fluorescent compounds. (122) A postcolumn photochemical reactor caused the cleavage of methotrexate to form the highly fluorescent 2,4-diaminopteridine-6-carboxyaldehyde.…”

Section: Aminesmentioning

confidence: 99%

Chemical Reagents and Derivatization Procedures in Drug Analysis

Danielson

Gallagher

Bao

2008

Encyclopedia of Analytical Chemistry

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This article describes both pre‐ and postcolumn derivatization chemistry used in conjunction with either chromatography or capillary electrophoresis (CE) to facilitate the determination of drugs. Generally, only prederivatization is used in gas chromatography (GC), principally to enhance the volatility, temperature stability, and/or detectability. The GC section considers derivatization of drugs by reagent class: alkylation, acylation, and silylation. The GC sample‐handling section describes an approach that combines the extraction and derivatization steps together. Both pre‐ and postcolumn derivatization are common approaches for high‐performance liquid chromatography (HPLC) and many of these methods have been adapted for CE. Derivatization for HPLC is often directed toward aliphatic amines, carboxylic acids, or alcohols that are difficult to detect at low levels by absorbance, luminescence, or electrochemical means. In addition, small hydrophilic molecules upon prederivatization are often converted into larger more hydrophobic compounds, making reversed‐phase HPLC easier or even feasible. The HPLC section considers derivatization of drugs based on the following types: alkaloids, amines, antibiotics, barbiturates, carbonyl compounds and carboxylic acids, catecholamines, hydroxy compounds, steroids, and sulfur compounds. For the GC and HPLC sections, tables are included, giving the structures of the more important derivatizing agents, the analytes, and the corresponding reaction products. A brief rationale for derivatization chemistry with CE concludes this article. For CE, derivatization is often done to improve detectability as the path length for absorbance detection is very short and fluorescence can be effective using laser‐based systems.

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Section: Aminesmentioning

confidence: 99%

Chemical Reagents and Derivatization Procedures in Drug Analysis

Danielson

Gallagher

Bao

2008

Encyclopedia of Analytical Chemistry

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“…Liquid chromatographic methods either directly or after hydrolysis and derivatization with fluorescamine were also reported [12,13].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations

Kulikov

Zinchenko

2007

Journal of Pharmaceutical and Biomedical Analysis

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“…The aim of this work was the determination of two active substances, a-bisabolol and D-panthenol, constituents of O W cosmetic emulsions [ l , 21. Most of the recent publications report determinations using high pressure liquid chromatography [3,4]. In this study, these two compounds were estimated using gas chromatography (51. a-Bisabolol is an unsaturated sesquiterpenic liquid alcohol whose boiling point is 260°C.…”

Section: Introductionmentioning

confidence: 99%

Determination of α‐bisabolol and d‐panthenol in cosmetic products by gas chromatography

Andre¹,

Vérité²,

Duclos³

et al. 1991

Intern J of Cosmetic Sci

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Synopsis alpha-bisaboloi and d-panthenol are used in many cosmetic preparations, respectively, for their anti-inflammatory and regenerating properties. Their quantitative determination was an important element of their evaluation in these emulsions. Their concentration has been determined by gas chromatographic techniques, using a flame ionization detector. In both cases, the internal standards have been chosen for their compatibility with the analysis of extracted substances. Owing to the complexity of the cosmetic formulations, a preliminary extraction of alpha-bisabolol and d-panthenol was necessary. For the two substances the preparative separation was based on a liquid-liquid extraction. After dissolving the emulsion in methanol and diluting it with an aqueous buffer solution alpha-bisabolol was then extracted by ethyl acetate and d-panthenol by ethyl formate.

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High performance liquid chromatographic determination of panthenol in bulk, premix and multivitamin preparations

Cited by 10 publications

References 0 publications

Chemical Reagents and Derivatization Procedures in Drug Analysis

Chemical Reagents and Derivatization Procedures in Drug Analysis

Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations

Determination of α‐bisabolol and d‐panthenol in cosmetic products by gas chromatography

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