High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection

G, Peinhardt

doi:10.1016/s0378-4347(99)00068-7

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…18) Pholedrine in a case of fatal intoxication was also studied using LC-MS/MS. The method developed is very sensitive with a limit of detection of 0.8 ng/ml (S/N = 3) and lower limit of quantitation of 3 ng/ml (S/N = 10).…”

Section: Blood Samplesmentioning

confidence: 99%

High-Performance Liquid Chromatographic Analysis of Drugs of Abuse in Biologic Samples

Nakashima

2005

JOURNAL OF HEALTH SCIENCE

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Recently, drug abuse has become a serious social problem world wide. In Japan, methamphetamine (MP) is the most popular drug of abuse. In addition to MP, the use of 4,5-methylenedioxymethamphetamine (MDMA), called ecstacy, is rapidly increasing, especially among young people. The development of simple and convenient analytical methods for the analysis of these drugs of abuse is necessary for the prediction of and protection from human health risks. Many useful methods have been developed for qualification and quantification of drugs of abuse. Among these, gas chromatography with mass spectrometry (MS) and high-performance liquid chromatography with MS (HPLC-MS or LC-MS) or fluorescence (HPLC-FL) detection are widely used. As highly sensitive methods, precolumn or postcolumn derivatization methods are commonly utilized in HPLC. This review focuses on HPLC methods used for the practical analysis of drugs of abuse, mainly for amphetamine derivatives and MDMAs in biologic samples such as urine, blood, and hair.

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Section: Blood Samplesmentioning

confidence: 99%

High-Performance Liquid Chromatographic Analysis of Drugs of Abuse in Biologic Samples

Nakashima

2005

JOURNAL OF HEALTH SCIENCE

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“…Therefore, a suitable and fast method for determination of MG seems particularly important. Several methods were reported for determination of MG, such as spectrophotometry, 4 high performance liquid chromatography (HPLC), [5][6][7][8] liquid chromatography mass spectrometry, [9][10][11] HPLC-amperometric detection, [12][13][14] flow injection analysis (FIA). 15 Every method has its advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

A novel self-assembly voltammetric sensor for malachite green based on ethylenediamine and graphene oxide

et al. 2012

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A novel self-assembly modified carbon paste electrode based on ethylenediamine and graphene oxide was proposed as a highly sensitive electrochemical sensor for detection of malachite green. The manufacturing operation of the recommended sensor was characterized by cyclic voltammetry and electrochemical impedance spectroscopy. The electrochemical response of malachite green at this sensor was investigated in detail and a new electroanalytical method was erected with high sensitivity and selectivity. The proposed method exhibited good linearity for malachite green over the range from 8.0 Â 10 À9 mol L À1 to 8.0 Â 10 À7 mol L À1 with the detection limit of 5 Â 10 À9 mol L À1 (S/N ¼ 3) by differential pulse voltammetry under optimum conditions. Finally, the practical application was proven by spiking malachite green standards in lake water with recoveries ranging from 98.80% to 101.10%, showing a satisfactory result.

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“…Thus, testing for pOHMA should also be conducted to ensure the reliability of the results. Several analytical methods for pOHMA have been described, [2][3][4][5][6][7][8] including methods based on thin-layer chromatography (TLC). Since pOHMA is a parasubstituted phenolic and a highly polar compound, it is in part excreted as a glucuronate-conjugated form in urine.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Analysis of p-Hydroxymethamphetamine in Urine by Thin-Layer Chromatography

Kato

Kubo²,

Homma³

2005

ANAL. SCI.

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High-performance liquid chromatographic determination of pholedrine in human serum using ion-pair extraction and amperometric detection

Cited by 4 publications

References 15 publications

High-Performance Liquid Chromatographic Analysis of Drugs of Abuse in Biologic Samples

High-Performance Liquid Chromatographic Analysis of Drugs of Abuse in Biologic Samples

A novel self-assembly voltammetric sensor for malachite green based on ethylenediamine and graphene oxide

Fluorescence Analysis of p-Hydroxymethamphetamine in Urine by Thin-Layer Chromatography

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