High-performance liquid chromatography in the analysis of multicomponent pharmaceutical preparations

A Review of the Extraction and Determination Methods of Thirteen Essential Vitamins to the Human Body: An Update from 2010

“…Sample extraction and purification is vitally important. In the pretreatment processes of vitamins, different substances can be separated and preconcentrated which can improve the analytical performance significantly (e.g., selectivity, sensitivity, accuracy) [ 30 , 31 ]. In the past, soxhelt extraction and heating under reflux have been the most commonly used methods; both these two methods have limitations due to the high costs of time and organic solvents.…”

“…The number of publications involving vitamins has increased significantly which demonstrates that these issues are becoming more and more popular. A lot of pretreatment and determination methods of vitamins were developed before 2010 [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. At that time, general pretreatment techniques included liquid–liquid extraction (LLE), solid-phase extraction (SPE) and so on, while the determination methods include chromatography methods, electrophoretic methods and others.…”

Simultaneous analysis of water-soluble and fat-soluble vitamins through RP-HPLC/DAD in food supplements and brewer’s yeast

“…Brewer’s yeast has been proposed mainly as a nutritional supplement due to the fact it is inexpensive source of vitamins, nucleic acids and β -glucans [ 39 ]. A great number of pretreatment methods of vitamins are developed [ [40] , [41] , [42] , [43] ] where the general pretreatment techniques, including liquid–liquid extraction (LLE), solid-phase extraction (SPE), ultrasonic assisted extraction (UAE), supercritical fluid extraction (SFE), SPE, LLE and dispersive liquid–liquid microextraction (DLLME) methodology [ [44] , [45] , [46] , [47] , [48] , [49] ]. Nevertheless, it is obvious that the sample extraction and purification approach is of vital importance for the proper pretreatment process, since it can significantly improve the analytical performance in means of selectivity, sensitivity, accuracy etc.…”

Pharmaceuticals and Related Drugs

“…In addition to the citations discussed previously in the General section, a variety of more specific reviews have been published that deal with topically related aspects of separation methodology. Among these are ones that discuss multicomponet analysis by HPLC (128), impurity determination using capillary electromigration methods (129), application of nonaqueous capillary electrophoresis (CE) to assay pharmaceuticals (130), recent developments of benzofurazan-based derivatizing reagents (131), and overviews of chiral analysis (132)(133)(134). In addition to more common separation methodology, in one of the latter reviews (132), the uses of other approaches are considered as costeffective alternatives to providing chiral information.…”