High performance of coating hydroxyapatite layer on 316L stainless steel using ultrasonically and alkaline pretreatment

Fadli, Ahmad; Prabowo, Agung; Yenti, Silvia Reni; Huda, Feblil; Liswani, Ayla Annisa; Hutauruk, Donda Lamsinar Br

doi:10.1016/j.jksus.2023.102681

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Because of its crystallographic composition, chemical structure, and similarity with the native tissue, HA forms a chemical connection between the osseous tissue and the surface of the biomedical implant. This encourages growth stimulation, and, therefore, the osseointegration process [96,97].…”

Section: Hydroxyapatite Applicationsmentioning

confidence: 99%

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Radulescu,

Vasile,

Andronescu

et al. 2023

IJMS

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Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.

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Section: Hydroxyapatite Applicationsmentioning

confidence: 99%

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Radulescu,

Vasile,

Andronescu

et al. 2023

IJMS

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“…Additionally, the large surface area of HA nanocrystals facilitates their rapid dissolution by osteoclasts, contributing to the maintenance of calcium ions in body fluids and promoting appropriate bone remodeling rates [ 3 ]. Due to these properties, synthetic hydroxyapatite has been used for many decades in the field of biomedical applications due to its similarity to native HA-containing bone [ 4 ]. This similarity results in high biocompatibility and osteogenic properties [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Osteogenic Potential of Nano-Hydroxyapatite and Strontium-Substituted Nano-Hydroxyapatite

Kontogianni

Coelho²,

Gauthier

et al. 2023

Nanomaterials

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Nanohydroxyapatite (nanoHA) is the major mineral component of bone. It is highly biocompatible, osteoconductive, and forms strong bonds with native bone, making it an excellent material for bone regeneration. However, enhanced mechanical properties and biological activity for nanoHA can be achieved through enrichment with strontium ions. Here, nanoHA and nanoHA with a substitution degree of 50 and 100% of calcium with strontium ions (Sr-nanoHA_50 and Sr-nanoHA_100, respectively) were produced via wet chemical precipitation using calcium, strontium, and phosphorous salts as starting materials. The materials were evaluated for their cytotoxicity and osteogenic potential in direct contact with MC3T3-E1 pre-osteoblastic cells. All three nanoHA-based materials were cytocompatible, featured needle-shaped nanocrystals, and had enhanced osteogenic activity in vitro. The Sr-nanoHA_100 indicated a significant increase in the alkaline phosphatase activity at day 14 compared to the control. All three compositions revealed significantly higher calcium and collagen production up to 21 days in culture compared to the control. Gene expression analysis exhibited, for all three nanoHA compositions, a significant upregulation of osteonectin and osteocalcin on day 14 and of osteopontin on day 7 compared to the control. The highest osteocalcin levels were found for both Sr-substituted compounds on day 14. These results demonstrate the great osteoinductive potential of the produced compounds, which can be exploited to treat bone disease.

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