High-performance PCB-based capillary pumps for affordable point-of-care diagnostics

Vasilakis, Nikolaos; Papadimitriou, Konstantinos I.; Morgan, Hywel; Prodromakis, Themis

doi:10.1007/s10404-017-1935-2

Cited by 22 publications

(12 citation statements)

References 28 publications

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“…On the other hand, passive microfluidics is other typical and well-known method used for driving fluids [ 95 ]. This method has also been used for printed circuit boards to develop high-performance PCB-based capillary pumps for affordable point-of-care diagnostics [ 96 , 97 ]. The flow can be created without actuation; for example, take the PCB-based self-breathing fuel cells [ 98 , 99 ].…”

Section: Other Methodsmentioning

confidence: 99%

Lab-on-PCB and Flow Driving: A Critical Review

Perdigones

2021

Micromachines

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Lab-on-PCB devices have been developed for many biomedical and biochemical applications. However, much work has to be done towards commercial applications. Even so, the research on devices of this kind is rapidly increasing. The reason for this lies in the great potential of lab-on-PCB devices to provide marketable devices. This review describes the active flow driving methods for lab-on-PCB devices, while commenting on their main characteristics. Among others, the methods described are the typical external impulsion devices, that is, syringe or peristaltic pumps; pressurized microchambers for precise displacement of liquid samples; electrowetting on dielectrics; and electroosmotic and phase-change-based flow driving, to name a few. In general, there is not a perfect method because all of them have drawbacks. The main problems with regard to marketable devices are the complex fabrication processes, the integration of many materials, the sealing process, and the use of many facilities for the PCB-chips. The larger the numbers of integrated sensors and actuators in the PCB-chip, the more complex the fabrication. In addition, the flow driving-integrated devices increase that difficulty. Moreover, the biological applications are demanding. They require transparency, biocompatibility, and specific ambient conditions. All the problems have to be solved when trying to reach repetitiveness and reliability, for both the fabrication process and the working of the lab-on-PCB, including the flow driving system.

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Section: Other Methodsmentioning

confidence: 99%

Lab-on-PCB and Flow Driving: A Critical Review

Perdigones

2021

Micromachines

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“…175 Vasilakis et al reviewed a simple highspeed lling passive capillary pump integrated with lab-onprinted circuit board technology (Lo-PCB), with induced capillary pressure to produce stable ow rates. 176 Akyazi et al developed a new concept for uid ow manipulation in micro paper-based analytical devices (PADs), where the ionogel (considered to be a negative passive pump) could drive uids by the swelling effect, which controlled the ow direction and volume to the outlet. 177 Frimat et al described a new single-cell trapping procedure within the micro sieve electrode array (SEA) through capillary phenomena for an organized positioning of neurons to produce higher biocompatibility.…”

Section: Capillarymentioning

confidence: 99%

Advances in passively driven microfluidics and lab-on-chip devices: a comprehensive literature review and patent analysis

et al. 2020

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“…Although they are continuously evolving, e.g. constantly updated capillary injection technology , the flow rate of sample stream is usually not sufficient for the flow cytometry. Syringe pumps and peristaltic pumps are more suitable for the microfluidic flow cytometry, since they are able to provide higher flow rate.…”

Section: Flow Control In Microfluidic Flow Cytometrymentioning

confidence: 99%

New advances in microfluidic flow cytometry

Gong

Fan

et al. 2018

Electrophoresis

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In recent years, researchers are paying the increasing attention to the development of portable microfluidic diagnostic devices including microfluidic flow cytometry for the point‐of‐care testing. Microfluidic flow cytometry, where microfluidics and flow cytometry work together to realize novel functionalities on the microchip, provides a powerful tool for measuring the multiple characteristics of biological samples. The development of a portable, low‐cost, and compact flow cytometer can benefit the health care in underserved areas such as Africa or Asia. In this article, we review recent advancements of microfluidics including sample pumping, focusing and sorting, novel detection approaches, and data analysis in the field of flow cytometry. The challenge of microfluidic flow cytometry is also examined briefly.

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High-performance PCB-based capillary pumps for affordable point-of-care diagnostics

Cited by 22 publications

References 28 publications

Lab-on-PCB and Flow Driving: A Critical Review

Lab-on-PCB and Flow Driving: A Critical Review

Advances in passively driven microfluidics and lab-on-chip devices: a comprehensive literature review and patent analysis

New advances in microfluidic flow cytometry

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