High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

Abstract

In this work, the β-cyclodextrin-MXene (β-CD-MXene) composite was employed as a modifier for carbon fiber paper (CFP) electrodes and quantification of L-methionine (L-Met). The β-CD-MXene composite was prepared by hydrothermal synthesis route by adding β-CD and Ti3C2Tx MXenes obtained via the Minimally intensive layer delamination technique. Cyclic voltammetry (CV) and Differential Pulse Voltammetry (DPV) were conducted to study the influence of scan rate and pH on the electrooxidation of L-Met studies using the β-CD-MXene/CFP electrode. The layered structure of the exfoliated Ti3C2Tx MXenes with charge transfer efficiency in combination with the host-guest interaction ability of β-CD enhances the electrooxidation of L-Met. The β-CD-MXene/CFP electrode showcased high sensitivity, reproducibility, and stability, and the anodic peak currents were in linearity with L-Met concentration within the range of 0.09–540 μM and LOD of 0.03 μM under various optimized conditions. In addition, the developed sensor showcases highly selective and non-interfering sensing of L-Met.