High photostability and enhanced fluorescence of gold nanoclusters by silver doping

Guével, Xavier Le; Trouillet, Vanessa; Spies, Christian; Li, Ké; Laaksonen, Timo; Auerbach, Dagmar; Jung, Gregor; Schneider, Marc

doi:10.1039/c2nr30653k

Cited by 105 publications

(74 citation statements)

References 40 publications

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“…Fluorescence enhancements of AuNCs could be observed for most of the cells while other cells attenuated the fluorescence of AuNCs. The increases of the fluorescence intensities may result from the better protection of the AuNCs by cells against the environment and inhibition of oxygen (O 2 )-mediated quenching [38, 92–97]. While the fluorescence quenching may be attributed to an energy or electron transfer process [98–101] or the aggregation of AuNCs [77, 102] induced by cells.…”

Section: Resultsmentioning

confidence: 99%

Pattern-based sensing of triple negative breast cancer cells with dual-ligand cofunctionalized gold nanoclusters

Tao

Auguste

2017

Biomaterials

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Early detection of breast cancer is a critical component in patient prognosis and establishing effective therapy regimens. Here, we developed an easily accessible yet potentially powerful sensor to detect cancer cell targets by utilizing seven dual-ligand cofunctionalized gold nanoclusters (AuNCs) as both effective cell recognition elements and signal transducers. On the basis of this AuNC multichannel sensor, we have successfully distinguished healthy, cancerous and metastatic human breast cells with excellent reproducibility and high sensitivity. Triple negative breast cancer cells (TNBCs), which exhibit low expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2, were identified. The high accuracy of the blind breast cell sample tests further validates the practical application of the sensor array. In addition, the versatility of the sensor array is further justified by identifying amongst distinct cell types, different cell concentrations and cell mixtures. Notably, the drug-resistant cancer cells can also be efficiently discriminated. Furthermore, the dual-ligand cofunctionalized AuNCs can efficiently differentiate different cells from the peripheral blood of tumor-free and tumor-bearing mice. Taken together, this fluorescent AuNCs based array provides a powerful cell analysis tool with potential applications in biomedical diagnostics.

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Section: Resultsmentioning

confidence: 99%

Pattern-based sensing of triple negative breast cancer cells with dual-ligand cofunctionalized gold nanoclusters

Tao

Auguste

2017

Biomaterials

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“…Moreover, λ em shows small bathochromic shifts for the Ag-doped clusters compared to the bare Au clusters. The QY boost in the photoluminescence is a feature of Ag-doped Au clusters [23,24,26,33,34]; however, the red shift in λ em was rarely reported [35]. We postulate that the shift in λ em for Ag/Au clusters is determined by the surface ligand and the method of Ag doping, but the exact reason is not well understood.…”

Section: Figurementioning

confidence: 87%

“…Moreover, doping Au 25 (SC 2 H 4 Ph) 18 clusters with a single platinum atom greatly enhances cluster stability against oxidation treatment and its catalytic activity [21], whereas doping Au 25 (SC 12 H 25 ) 18 clusters with silver atoms shifts the optical spectra and fluorescence peaks by modulating the electronic structure [22]. Of such bimetallic clusters, Au/Ag alloy clusters [23][24][25][26] are especially fascinating because they often manifest significantly enhanced luminescence, which is beneficial for sensing and bioimaging.…”

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confidence: 98%

Microwave-assisted synthesis of photoluminescent glutathione-capped Au/Ag nanoclusters: A unique sensor-on-a-nanoparticle for metal ions, anions, and small molecules

et al. 2015

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Even though great advances have been achieved in the synthesis of luminescent metal nanoclusters, it is still challenging to develop metal nanoclusters with high quantum efficiency as well as multiple sensing functionalities. Here, we demonstrate the rapid preparation of glutathione-capped Au/Ag nanoclusters (GS-Au/Ag NCs) using microwave irradiation and their unique sensing capacities. Compared to bare GS-Au NCs, the doped Au/Ag NCs possess an enhanced quantum yield (7.8% compared to 2.2% for GS-Au NCs). Several characterization techniques were used to elucidate the atomic composition, particulate character, and electronic structure of the fabricated NCs. According to the X-ray photoelectron spectroscopy (XPS) and X-ray absorption near-edge structure (XANES) spectra, a significant amount of Au exists in the oxidized state as Au(I), and the Ag atoms are positively charged. In contrast to those nanoclusters that detect only one analyte, the GS-Au/Ag NCs can be used as a versatile sensor for metal ions, anions, and small molecules. In this manner, the NCs can be regarded as a unique sensor-on-a-nanoparticle.

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“…In order to develop brighter metallic NCs, silver was introduced in the preparation of Au NCs protected by glutathione. Silver doping Au NCs was prepared by Le Guevel et al as luminescent probes in lung cancer cells (A549). The properties of high photostability and easy detection attract special attention for their possible applications in bioimaging and sensing.…”

Section: Applicationsmentioning

confidence: 99%

Fluorescent Metallic Nanoclusters: Electron Dynamics, Structure, and Applications

Wen

Toh

et al. 2014

Part. Part. Syst. Charact.

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Atomically precise Au nanoclusters (NCs) have emerged as fascinating fluorescent nanomaterials and attracted considerable research interest in both fundamental research and practical applications. Due to enhanced quantum confinement, they possess extraordinary optical, electronic, and magnetic properties and therefore are very promising for a wide range of applications, including biosensing, bioimaging, catalysis, photonics, and molecular electronics. Remarkable progress has been reported for the fundamental understanding, synthesis techniques, and applications. In this review, the updated advances are summarized in Au NCs, including synthesis techniques, optical properties, and applications. In particular, we focus on the optical properties and electron dynamic processes. In addition, the progress in other noble metallic NCs is included in this Review, such as Ag, Cu, Pt, and alloy, which have attracted much research interest recently. Finally, an outlook is presented for such fascinating nanomaterials in both aspects of future fundamental research and potential applications.

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High photostability and enhanced fluorescence of gold nanoclusters by silver doping

Cited by 105 publications

References 40 publications

Pattern-based sensing of triple negative breast cancer cells with dual-ligand cofunctionalized gold nanoclusters

Pattern-based sensing of triple negative breast cancer cells with dual-ligand cofunctionalized gold nanoclusters

Microwave-assisted synthesis of photoluminescent glutathione-capped Au/Ag nanoclusters: A unique sensor-on-a-nanoparticle for metal ions, anions, and small molecules

Fluorescent Metallic Nanoclusters: Electron Dynamics, Structure, and Applications

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