High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus

Brehm, Katharina Erika Gerda; Kumar, Naveen; Thulke, Hans‐Hermann; Haas, Bernd

doi:10.1016/j.vaccine.2008.01.038

Cited by 130 publications

(108 citation statements)

References 15 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…However, a different approach to predict protection using in vitro analysis and specific antibody responses has also been described by Brehm et al [50]. Taking into consideration that we have vaccinated with SAT2 vaccines, the predicted protection of >85% is based on the comparison of the SAT2 heterologous titres in this study with the protective titres in the study of Brehm et al [50]. This also correlates with the predictions from Barnett et al [49].…”

Section: Discussionsupporting

confidence: 79%

“…From previ-ous work predicting protection using in vitro analysis and specific antibody responses [49] we can anticipate that >88% of animals vac-cinated with either SAT2/ZIM/14/90 or vSAT2 ZIM14 -SAT2 vaccines would be protected against heterologous challenge with the viruses in this study. However, a different approach to predict protection using in vitro analysis and specific antibody responses has also been described by Brehm et al [50]. Taking into consideration that we have vaccinated with SAT2 vaccines, the predicted protection of >85% is based on the comparison of the SAT2 heterologous titres in this study with the protective titres in the study of Brehm et al [50].…”

Section: Discussionmentioning

confidence: 94%

“…Serum samples collected at 21 dpv were also used to assess the neutralizing antibody response against a panel of SAT2 reference viruses and field isolates: SAT2/KNP/19/89, SAT2/ SAR/3/04, SAT2/SAR/1/10, SAT2/SAR/4/12, SAT2/NAM/1/07, SAT2/ NAM/1/08, SAT2/BOT/4/06 and SAT2/ZIM/7/83. The antibody titres were calculated as log 10 of the reciprocal of the final serum dilution that neutralized 100 TCID 50 of virus in 50% of the wells [42].…”

Section: Virus Neutralization Test (Vnt)mentioning

confidence: 99%

See 2 more Smart Citations

Intra-serotype SAT2 chimeric foot-and-mouth disease vaccine protects cattle against FMDV challenge

Maree

Nsamba

Mutowembwa

et al. 2015

Vaccine

View full text Add to dashboard Cite

The genetic diversity of the three Southern African Territories (SAT) types of foot-and-mouth disease virus (FMDV) reflects high antigenic variation, and indications are that vaccines targeting each SATspecific topotype may be needed. This has serious implications for control of FMD using vaccines as well as the choice of strains to include in regional antigen banks. Here, we investigated an intra-serotype chimeric virus, vSAT2 ZIM14 -SAT2, which was engineered by replacing the surface-exposed capsid-coding region (1B-1D/2A) of a SAT2 genome-length clone, pSAT2, with that of the field isolate, SAT2/ZIM/14/90. The chimeric FMDV produced by this technique was viable, grew to high titres and stably maintained the 1B-1D/2A sequence upon passage. Chemically inactivated, oil adjuvanted vaccines of both the chimeric and parental immunogens were used to vaccinate cattle. The serological response to vaccination showed the production of strong neutralizing antibody titres that correlated with protection against homologous FMDV challenge. We also predicted a good likelihood that cattle vaccinated with an intra-serotype chimeric vaccine would be protected against challenge with viruses that caused recent outbreaks in southern Africa. These results provide support that chimeric vaccines containing the external capsid of field isolates induce protective immune responses in FMD host species similar to the parental vaccine.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 94%

Section: Virus Neutralization Test (Vnt)mentioning

confidence: 99%

See 1 more Smart Citation

Intra-serotype SAT2 chimeric foot-and-mouth disease vaccine protects cattle against FMDV challenge

Maree

Nsamba

Mutowembwa

et al. 2015

Vaccine

View full text Add to dashboard Cite

show abstract

“…Antigenic analysis of field isolates in relation to vaccine strains, based on VNTs, play a significant role in evaluating the suitability of existing vaccine strains (Jangra et al, 2005;Paton et al, 2005;Brehm et al, 2008), despite significant variation having been reported with VNTs (Rweyemamu et al, 1978(Rweyemamu et al, , 1984. It is generally accepted that r 1 -values higher than 0.4 demonstrates a good cross-protection of the vaccine against the field isolate (Samuel et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

Predicting antigenic sites on the foot-and-mouth disease virus capsid of the South African Territories types using virus neutralization data

Maree

Blignaut

Esterhuysen

et al. 2011

Journal of General Virology

View full text Add to dashboard Cite

Foot-and-mouth disease virus (FMDV) outer capsid proteins 1B, 1C and 1D contribute to the virus serotype distribution and antigenic variants that exist within each of the seven serotypes. This study presents phylogenetic, genetic and antigenic analyses of South African Territories (SAT) serotypes prevalent in sub-Saharan Africa. Here, we show that the high levels of genetic diversity in the P1-coding region within the SAT serotypes are reflected in the antigenic properties of these viruses and therefore have implications for the selection of vaccine strains that would provide the best vaccine match against emerging viruses. Interestingly, although SAT1 and SAT2 viruses displayed similar genetic variation within each serotype (32 % variable amino acids), antigenic disparity, as measured by r 1 -values, was less pronounced for SAT1 viruses compared with SAT2 viruses within our dataset, emphasizing the high antigenic variation within the SAT2 serotype. Furthermore, we combined amino acid variation and the r 1 -values with crystallographic structural data and were able to predict areas on the surface of the FMD virion as antigenically relevant. These sites were mostly consistent with antigenic sites previously determined for types A, O and C using mAbs and escape mutant studies. Our methodology offers a quick alternative to determine antigenic relevant sites for FMDV field strains.

show abstract

“…However, the protective efficacy of FMD vaccine can be evaluated through vaccine matching using indirect serological methods (Rweyemamu 1984a;Rweyemamu 1984b) and it can also be calculated using the relatedness between the field isolate and available vaccine strains using in vivo challenge tests (Brehm et al, 2008;Goris et al, 2008). Selection of viruses for vaccine matching is very important and should be based on epidemiological information, including stages of an epidemic, geographical locations or range of host species (Alonso et al, 1993;Paton et al, 2005) by incorporating a minimum of two isolates from outbreak (OIE, 2008).…”

Section: Introductionmentioning

confidence: 99%

Foot-and-mouth disease virus isolates: Candidate strains for trivalent vaccine development in Nigeria

Ibu¹,

Abenga²,

Lazarus³

et al. 2016

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

A quality foot and mouth disease (FMD) vaccine is a prerequisite for effective control in addition to other zoosanitary measures and effective biosecurity practices in disease endemic sub-Saharan countries like Nigeria. To ensure an effective control programme by vaccination, countries that practice mass vaccination campaigns need to conduct vaccine matching studies to establish a relationship between prevalent field isolates with available vaccine for effective control. To this effect, a research was conducted in order to select foot-and-mouth disease viruses (FMDV) that will give a quality vaccine containing relevant serotypes and matching strains as a pre-requisite for effective vaccine. The study was conducted using two dimensional virus neutralization assays to determine the antigenic relationship 'r' value between the candidate vaccine strains and the field isolates. A total of forty-two specimens (epithelial tissue) were send to the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD) for virus detection and antigen serotyping and some of the field isolates were selected for vaccine matching based on geographic location and topotypes/subtype. The isolates selected were two each of serotype O, A and SAT 2 from bovine species. The selected field isolates revealed high antigenic similarity with the vaccine strains tested showing 'r' value greater than 0.3 which suggests a close relationship between field isolates and vaccine strain tested. A potent vaccine containing the vaccine strain is likely to confer protection in vaccinated candidates. A vaccine match with 'r' value less than 0.3 suggests poor protection against challenge with the isolates. The result of this study has indicated that the selected field isolates could be used as vaccine strains for a candidate trivalent FMD vaccine production in Nigeria.

show abstract

High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus

Cited by 130 publications

References 15 publications

Intra-serotype SAT2 chimeric foot-and-mouth disease vaccine protects cattle against FMDV challenge

Intra-serotype SAT2 chimeric foot-and-mouth disease vaccine protects cattle against FMDV challenge

Predicting antigenic sites on the foot-and-mouth disease virus capsid of the South African Territories types using virus neutralization data

Foot-and-mouth disease virus isolates: Candidate strains for trivalent vaccine development in Nigeria

Contact Info

Product

Resources

About