High pressure does not counterbalance the advantages of open techniques over closed techniques during heated intraperitoneal chemotherapy with oxaliplatin

Facy, Olivier; Combier, C; Poussier, M.; Magnin, Guy; Ladoire, Sylvain; Ghiringhelli, François; Chauffert, Bruno; Rat, Patrick; Ortega‐Deballon, Pablo

doi:10.1016/j.surg.2014.06.006

Cited by 29 publications

(28 citation statements)

References 21 publications

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“…It has also been shown that in patients heavily pretreated with OXAL, a redistribution of the pool of intra-erythrocytic OXAL biotransformation products into the plasma may aggravate neurotoxic effect of OXAL [38]. Notably, a current study showed that, in heat intraperitoneal chemotherapy with OXAL which is not standard chemotherapy, the OXAL concentrations in tissue can be around 47-85 mg/Kg (118-214 µM) [39]. Additionally, recent investigations have focused on the utilization of different drug-delivery vehicles in facilitating specific delivery of OXAL to tumor tissues [40,41].…”

Section: Discussionmentioning

confidence: 62%

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca2+-Activated K+ Channels in Human Glioma Cells

Huang

2015

Cell Physiol Biochem

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Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels in glioma cells is poorly understood. OXAL (100 µM) suppressed the amplitude of whole-cell K⁺ currents (I_K); and, either DCEBIO or ionomycin significantly reversed OXAL-mediated inhibition of I_K in human 13-06-MG glioma cells. In OXAL-treated cells, TRAM-34 did not suppress I_K amplitude in these cells. The intermediate-conductance Ca²⁺-activated K⁺ (IK_Ca) channels subject to activation by DCEBIO and to inhibition by TRAM-34 or clotrimazole were functionally expressed in these cells. Unlike cisplatin, OXAL decreased the probability of IK_Ca-channel openings in a concentration-dependent manner with an IC₅₀ value of 67 µM. No significant change in single-channel conductance of IK_Ca channels in the presence of OXAL was demonstrated. Neither large-conductance Ca²⁺-activated K⁺ channels nor inwardly rectifying K⁺ currents in these cells were affected in the presence of OXAL. OXAL also suppressed the proliferation and migration of 13-06-MG cells in a concentration- and time-dependent manner. OXAL reduced IK_Ca-channel activity in LoVo colorectal cancer cells. Taken together, the inhibition by OXAL of IK_Ca channels would conceivably be an important mechanism through which it acts on the functional activities of glioma cells occurring in vivo.

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Section: Discussionmentioning

confidence: 62%

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca2+-Activated K+ Channels in Human Glioma Cells

Huang

2015

Cell Physiol Biochem

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“…A recent study by Facy et al, conducted on a swine model, reported that increased intra-abdominal pressure when applying the closed HIPEC technique resulted in tachycardia, a decrease in blood pressure despite more aggressive fluid resuscitation, and an increase in ventilation pressure [6]. …”

Section: Discussionmentioning

confidence: 99%

“…Even with the application of high pressure with the closed technique, hypothesized to increase drug tissue penetration, the open technique still seems to attain better intraperitoneal distribution and enhanced tissue uptake [6]. …”

Section: Discussionmentioning

confidence: 99%

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Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec

Halkia

Tsochrinis

Vassiliadou

et al. 2015

International Journal of Surgical Oncology

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Background. Peritoneal carcinomatosis (PC) is associated with a poor prognosis. Cytoreductive surgery (CRS) and HIPEC play an important role in well-selected patients with PC. The aim of the study is to present the differences in the intraoperative parameters in patients who received HIPEC in two different manners, open versus closed abdomen. Patients and Methods. The population includes 105 patients with peritoneal carcinomatosis from colorectal, gastric, and ovarian cancer, sarcoma, mesothelioma, and pseudomyxoma peritonei. Group A (n = 60) received HIPEC using the open technique and Group B (n = 45) received HIPEC with the closed technique. The main end points were morbidity, mortality, and overall hospital stay. Results. There were two postoperative deaths (3.3%) in the open group versus no deaths in the closed group. Twenty-two patients in the open group (55%) had grade III-IV complications versus 18 patients in the closed group (40%). There are more stable intraoperative conditions in the closed abdomen HIPEC in CVP, pulse rate, and systolic pressure parameters. Conclusions. Both methods are equal in the HIPEC procedures. Perhaps the closed method is the method of choice for frail patients due to more stable hemodynamic parameters.

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“…The consensus statement issued by the Peritoneal Surface Oncology Group International after the summit in Milan in 2006 reached the conclusion that the best technique to deliver HIPEC is yet the open one, without sufficient evidence in the literature to prove the superiority of one technique over the other regarding outcome, morbidity, and personnel safety (77,78). A study by Facy et al, conducted on a swine model, reported that increased intra-abdominal pressure when applying the closed HIPEC technique resulted in tachycardia, a decrease in blood pressure despite more aggressive fluid resuscitation, and an increase in ventilation pressure (79). Therefore, even though the requirement of minimally invasive procedure makes it more attractive to opt for laparoscopic maneuvers, but however the laparoscopic approach does not guarantee lower morbidity or any improvement in the complications of the procedure.…”

Section: Laparoscopic Hipec Vs Open Hipecmentioning

confidence: 99%

A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical management of advanced gastric cancer: an effective multimodality approach with scope for improvement

Beeharry

Yao

et al. 2016

Transl. Gastroenterol. Hepatol.

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Peritoneal carcinomatosis (PC) is manifested in up to 40% of gastric cancer (GC) patients, after which their 5-year survival drops to less than 5%. The currently most acceptable treatment option for advanced GC (AGC) is systemic chemo and radio therapies with however generally very unsatisfying results and this led to a resurgence of interest in regional therapies like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Small trials have indicated an association with prolonged survival when applying this technique to AGC manifesting with PC. High procedure-related morbidity and mortality associated with the CRS-HIPEC approach have however brought by a polemic on the merits of the latter: with the advent of regulatory approval of more effective as well as novel, more personalized treatment options in AGC, along with advances in tailoring investigational agents specifically for peritoneal delivery, there clearly is a need to outline the appropriate role of CRS-HIPEC in this disease.In a clear objective to improve the therapeutic efficiency of HIPEC, there have been immense developments in the technical aspects of this technology including the use of nanotechnology in more precise drug delivery systems (DDS) or choice of more efficient drugs such as gene-target technology, laparoscopy and so on. Henceforth, in this review, we will be highlighting the past and current status of the CRS + HIPEC procedure, shedding light on the pros and cons in order to boost up the efficiency of this multimodality approach.

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High pressure does not counterbalance the advantages of open techniques over closed techniques during heated intraperitoneal chemotherapy with oxaliplatin

Cited by 29 publications

References 21 publications

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca2+-Activated K+ Channels in Human Glioma Cells

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca2+-Activated K+ Channels in Human Glioma Cells

Peritoneal Carcinomatosis: Intraoperative Parameters in Open (Coliseum) versus Closed Abdomen Hipec

A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical management of advanced gastric cancer: an effective multimodality approach with scope for improvement

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