High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome

Fine, Kenneth D.; Kim, Do; Schulte, Kathleen Q.; Ogunji, F. O.; Guerra, Rudy; Osowski, Lori D.; McCormack, Jeffrey M.

doi:10.1111/j.1572-0241.2000.02255.x

Cited by 118 publications

(35 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human leukocyte antigen (HLA) studies have shown an association between MC and HLA-DQ2 or DQ1/3, and recently an association has reported between MC and HLA-DR3-DQ2 haplotype and with TNF2 allele carriage, irrespective of the presence of concomitant celiac disease [50,51] . Variants of the MMP-9 gene have been reported to be associated with CC [52] .…”

Section: Geneticsmentioning

confidence: 99%

Diagnosis and management of microscopic colitis

Tysk¹,

Bohr²,

Nyhlin³

et al. 2008

WJG

View full text Add to dashboard Cite

Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4-6/100 000 inhabitants, with a peak incidence in 60-70-year-old individuals and a noticeable female predominance for collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue and fecal incontinence are common symptoms, which impair the health-related quality of life of the patient. There is an association with other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented shortterm treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low.

show abstract

Section: Geneticsmentioning

confidence: 99%

Diagnosis and management of microscopic colitis

Tysk¹,

Bohr²,

Nyhlin³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…An interesting point of view is the possibility of an abnormal reaction to a luminal antigen. This is supported by the reported coincidence of coeliac disease (CD) and LC and the detection of anti-gliadin, anti-endomysial and anti-tissue transglutaminase antibodies in up to 17% of the patients with LC [8][9][10].…”

Section: Introductionmentioning

confidence: 57%

Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease

2010

View full text Add to dashboard Cite

Lymphocytic colitis (LC) is a disease of unknown aetiology. Among other pathogenetic possibilities, an abnormal reaction to a luminal antigen has been discussed. To clarify this fact, we characterized the inflammatory infiltrate in LC and compared it with the Th1 response-related coeliac disease (CD). Biopsies from 10 LC and 10 CD patients were analyzed by immunohistochemistry for detection of T-bet, the master regulator of Th1 response and its antagonist GATA-3 in T cells employing double labellings. In LC, 10-20% of intraepithelial lymphocytes (IEL) expressed GATA-3 and the remaining T-bet, whereas in CD, all IEL were T-bet-positive. The T cells in the lamina propria of LC (65-70% CD4+; 30-35% CD8+) showed a mixed expression pattern of T-bet and GATA-3. The majority of the CD4+ T cells were GATA-3+, while T-bet and GATA-3 were expressed at a similar frequency by the CD8+ T cells. Most of the T cells in the lamina propria of CD specimens were CD4+, showing a predominant T-bet expression. Also, most of the CD8+ lamina propria T cells in CD were T-bet+. We conclude that in contrast to CD, which exhibits immunophenotypical features of a Th1-response, LC shows features of a mixed Th1/Th2 immune response.

show abstract

“…Reports of familial clustering of MC [79], associations with certain HLA haplotypes (HLA-DQ2 or DQ1,3) [80], and polymorphisms in TNF-a gene [81] suggest a possible underlying genetic component. The strong association with autoimmune conditions suggests an underlying immune dysregulation.…”

Section: Microscopic Colitis (Mc)mentioning

confidence: 99%

Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded

et al. 2012

View full text Add to dashboard Cite

The interpretation of colonic biopsies related to inflammatory conditions can be challenging because the colorectal mucosa has a limited repertoire of morphologic responses to various injurious agents. Only few processes have specific diagnostic features, and many of the various histological patterns reflect severity and duration of the disease. Importantly the correlation with endoscopic and clinical information is often cardinal to arrive at a specific diagnosis in many cases.

show abstract

High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome

Cited by 118 publications

References 35 publications

Diagnosis and management of microscopic colitis

Diagnosis and management of microscopic colitis

Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease

Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded

Contact Info

Product

Resources

About