High prevalence of storage mite sensitization in a general adult population

Vidal, Carmen; Boquete, O.; Gudé, Francisco; Rey, José Manuel Gándara; Meijide, L. M.; Fernández-Merino, M C; González‐Quintela, Arturo

doi:10.1111/j.1398-9995.2003.00430.x

Cited by 58 publications

(62 citation statements)

References 23 publications

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“…These results are consistent with those observed for the allergic human population of Galicia, where sensitisation to storage mites (86%) is more prevalent than sensitisation to D. pteronyssinus (50.4%), which was traditionally considered the main allergen in Galicia (Vidal et al, 2004). …”

Section: Discussionsupporting

confidence: 90%

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Goicoa

Espino

Rodriguez

et al. 2008

Acta Veterinaria Hungarica

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Sensitisation to mites is frequent in atopic dogs. The main mite genus involved in canine atopic dermatitis is Dermatophagoides. The importance of storage mite allergens in dogs has been controversial. The aim of this study was to evaluate the sensitisation rates against storage mites (Lepidoglyphus destructor and Tyrophagus putrescentiae) and house dust mites (Dermatophagoides farinae and D. pteronyssinus) in atopic dogs from Galicia, a highly humid and temperate region of Spain, using a FcεRIα-based immunoglobulin E (IgE) in vitro test. The study was performed on 95 dogs suffering from atopic dermatitis and presenting detectable specific serum IgE levels: 91.6% of the dogs tested positive for storage mites, whereas sensitisation to house dust mites was detected in 87.4%. These results indicate the importance of storage mites in this specific geographic area.

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Section: Discussionsupporting

confidence: 90%

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Goicoa

Espino

Rodriguez

et al. 2008

Acta Veterinaria Hungarica

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“…Only patients sensitized to HDM and with symptoms of HDM were included. Patients with positive SPT results for Dermatophagoides also underwent SPTs for L destructor, which is highly prevalent in the region [6][7][8].…”

Section: Study Populationmentioning

confidence: 99%

Association Between Asthma and Sensitization to Allergens of Dermatophagoides pteronyssinus

Vidal¹,

Lojo²,

Juangorena³

et al. 2016

J Investig Allergol Clin Immunol

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Background: Little is known about the role of molecular diagnosis in house dust mite (HDM) allergy. Objective: In this study, we investigated the association between the sensitization profile of adolescent and adult HDM-allergic patients and asthma in a region with high rates of exposure to HDM. Methods: We conducted a cross-sectional study of 384 HDM-allergic patients (38.5%, males; median age, 28 years). A total of 368 patients (95.8%) had rhinitis, and 175 (45.6%) had asthma. Specific IgE (sIgE) to Dermatophagoides pteronyssinus, nDer p 1, rDer p 2, and rPen a 1 was measured in all patients. sIgE to Lepidoglyphus destructor was measured in patients (n=301) with a positive skin test result. Results: Significantly higher concentrations of sIgE to Der p 1 and sIgE to Der p 2 were observed in patients with asthma than in those without asthma. The proportion of asthmatic patients was higher among individuals who reacted (≥0.35 kU A /L) to both Der p 1 and Der p 2 (147/291, 50.5%) than among those who reacted to only 1 allergen (either Der p 1 or Der p 2, 18/55, 32.7%) or neither allergen (10/38, 26.3%, P=.002). Reactivity to both allergens was associated with asthma after adjusting for age and sex (OR, 2.87; 95%CI,. Higher concentrations of sIgE to L destructor were observed in patients with asthma than in patients without asthma. Tropomyosin sIgE ≥0.35 kU A /L was detected in only 6 individuals (1.6%). Conclusions: L destructor may be a relevant allergen in high-exposure areas. Dual sensitization (ie, IgE to both Der p 1 and Der p 2) may help to identify HDM-allergic patients who are at risk of asthma.

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“…Active smoking may even impair responsiveness to therapeutic intervention with corticosteroids (19 -21). Other studies, however, have either failed to find such associations (22)(23)(24) or have found smokers to be at significantly lower risk of developing asthma compared with nonsmokers and ex-smokers (24,25). Indeed, Hjern et al (26) have shown that cigarette smoke may in fact attenuate the development of allergic responses, as indicated by an inverse correlation between the prevalence of allergic asthma or rhinoconjunctivitis and the number of cigarettes smoked.…”

mentioning

confidence: 99%

Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization

Robbins

Pouladi

Fattouh

et al. 2005

The Journal of Immunology

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The purpose of this study was to investigate the impact of mainstream cigarette smoke exposure (MTS) on allergic sensitization and the development of allergic inflammatory processes. Using two different experimental murine models of allergic airways inflammation, we present evidence that MTS increased cytokine production by splenocytes in response to OVA and ragweed challenge. Paradoxically, MTS exposure resulted in an overall attenuation of the immune inflammatory response, including a dramatic reduction in the number of eosinophils and activated (CD69+) and Th2-associated (T1ST2+) CD4 T lymphocytes in the lung. Although MTS did not impact circulating levels of OVA-specific IgE and IgG1, we observed a striking reduction in OVA-specific IgG2a production and significantly diminished airway hyperresponsiveness. MTS, therefore, plays a disparate role in the development of allergic responses, inducing a heightened state of allergen-specific sensitization, but dampening local immune inflammatory processes in the lung.

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High prevalence of storage mite sensitization in a general adult population

Abstract: SMs (T. putrescentiae and L. destructor) are major aeroallergens in adults in the region studied, even in subjects without occupational exposure.

Cited by 58 publications

References 23 publications

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Association Between Asthma and Sensitization to Allergens of Dermatophagoides pteronyssinus

Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization

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