High Proteoglycan Decorin Levels Are Associated With Acute Coronary Syndrome and Provoke an Imbalanced Inflammatory Response

Abstract

Background and Aims: Acute coronary syndrome (ACS) has become one of the most common causes of disability. It is thus important to identify ACS early in the disease course of patients using novel biomarkers for prompt management. Decorin (DCN) was well-acknowledged for its effect on collagen fibrillogenesis and maintaining tissue integrity. Additionally, DCN could release as secreted proteoglycan under pathological conditions. Hence, we aimed to determine the relationship between serum DCN concentration and ACS.Methods: A total of 388 patients who underwent coronary angiography (CAG) in the cardiovascular center of Ruijin Hospital between June 2016 and December 2017 were enrolled in this study. Blood samples were drawn during CAG surgery to determine the serum DCN level of patients with ACS (n = 210) and control subjects (n = 178) using enzyme-linked immunosorbent assay.Results: We found that the serum DCN levels of ACS patients were elevated compared with those of the control subjects (13.59 ± 0.50 vs. 13.17 ± 0.38, respectively, p < 0.001). Furthermore, the serum DCN level, after being adjusted with other cardiovascular factors, was independently associated with ACS. Moreover, an increased serum DCN level was positively correlated with the number of white blood cells and the level of high-sensitivity C-reactive protein (R = 0.3 and 0.11, respectively). Mechanistically, DCN might have elicited an imbalanced inflammatory response during cardiac ischemia by suppressing the expression of anti-inflammatory genes.Conclusion: Serum DCN is a novel biomarker of ACS and contributes to the increased inflammatory response in ischemic heart disease.

Mechanism of Saffron Extract against Cardiotoxicity Induced by Doxorubicin: 4D Label-Free Quantitative proteomics Analysis and Bioinformatic Study

“…Decorin (DCN) is widely known for its effects on collagen bril production and the maintenance of tissue integrity. DCN can be released as a secreted proteoglycan under pathological conditions, and serum DCN is a novel biomarker of acute coronary syndrome that contributes to the increased in ammatory response in ischemic heart disease [79]. Our study found that DCN was signi cantly upregulated in the DOX group compared to the CONT group, while DCN was signi cantly downregulated in the SE group compared to the DOX group.…”

Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases

“…Accumulating evidence supports the role of certain myokines in CVD, with some having the potential to serve as novel biomarkers reflecting disease development (Table 1 , Ref. [ 12 , 13 , 14 , 18 , 19 , 20 , 21 , 24 , 25 , 26 , 34 , 38 , 39 , 40 , 41 , 44 , 46 , 47 , 54 , 56 , 57 , 60 , 62 , 63 , 65 , 66 , 67 , 72 , 73 , 77 , 78 , 81 , 82 , 83 , 87 , 88 , 89 , 90 , 91 , 95 , 96 , 97 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 113 , 115 , 116 , 117 , 119 , 120 , 121 , 122 , 125 , 126 , 128 ]). Myokines are involved in CVD development and can provide new insights into CVD progression and help identify patients at a high risk of poor prognosis.…”

“…DCN plays a role in the MI remodeling process by promoting cardiomyocyte survival following IR injury [ 124 ]. Serum DCN levels were significantly higher in patients with acute coronary syndrome (ACS) than in the control group [ 125 ]. Notably, serum DCN levels were significantly higher in pre-eclamptic women than in both controls and chronically hypertensive pregnant women [ 126 ].…”

The Proteoglycans Biglycan and Decorin Protect Cardiac Cells against Irradiation-Induced Cell Death by Inhibiting Apoptosis

“…To achieve a homogeneous dose distribution, 2 cm thick polymethylmethacrylate (PMMA) sheets were applied above and below the sample. After the irradiation, cells were treated with 0.001-0.1 nM BGN (Sigma-Aldrich, St. Louis, MO, USA, Cat#B8041) or DCN (Sigma-Aldrich, St. Louis, MO, USA, Cat#D8428) based on previously published plasma concentrations [31][32][33][34] and preliminary experiments or their vehicle solution. To determine the effect of irradiation, a group of cells was kept under control conditions and treated with the vehicle of BGN (distilled water) or DCN (phosphate buffered saline; PBS).…”