The fracture position of a friction plug welding (FPW) joint is typically located at or near the thermo-mechanically affected zone (TMAZ). Here, we found that microcracks in all FPW specimens initiate at the deformed plug center (DPC) zone and then propagate through the plug center along 45° shear surfaces, because the lowest hardness occurs at the DPC zone rather than the TMAZ or other zones, and the DPC zone presents a tilt fiber-like microstructure. Such a tilt microstructure stimulates formations and deformations of microvoids and propagation of microcracks along 45° shear surfaces. The ultimate tensile strength (237.7 MPa) and yield strength (220.8 MPa) of the FPW joint reach 78.8% and 85.7% of the base metal, respectively. These results indicate that 6061-T6 aluminum alloy can be effectively joined by the FPW technique.