High-resolution computed tomography in cystic fibrosis

Taccone, A; Romanò, Luca; Marzoli, A; Girosi, Donata; Dell'Acqua, A; Romano, C.

doi:10.1016/0720-048x(92)90137-x

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…It has been shown that thin-section CT scans are superior to chest radiographs to monitor structural aspects of pulmonary disease in cystic fibrosis (18). Radiation dose is of concern, however, since life expectancy is increasing in patients with cystic fibrosis (19).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Disease Assessment in Cystic Fibrosis: Comparison of CT Scoring Systems and Value of Bronchial and Arterial Dimension Measurements

Jong

Ottink²,

Robben³

et al. 2004

Radiology

161

101

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Section: Discussionmentioning

confidence: 99%

Pulmonary Disease Assessment in Cystic Fibrosis: Comparison of CT Scoring Systems and Value of Bronchial and Arterial Dimension Measurements

Jong

Ottink²,

Robben³

et al. 2004

Radiology

161

101

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“…This preponderance of irreversible lesions, such as bronchiectasis, is due to a greater structural involvement of the airways in the Pa group, which comprised individuals who were chronically exposed to infection/inflammation. (17,18) The presence of bronchiectasis seems to be one of the most important factors in the longitudinal deterioration of pulmonary function in patients with CF. (12) A study involving 82 patients with CF and evaluating 12 risk factors for developing irreversible lesions (such as bronchiectasis) found that only colonization with mucoid P. aeruginosa was significantly correlated with the presence of bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

Escore tomográfico em pacientes com fibrose cística colonizados por Pseudomonas aeruginosa ou Staphylococcus aureus

et al. 2012

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Objective: To compare HRCT findings in cystic fibrosis (CF) patients chronically colonized with Pseudomonas aeruginosa or Staphylococcus aureus using the modified Bhalla CT scoring system, as well as to evaluate intraobserver and interobserver reliability of the method. Methods: This was a retrospective cross-sectional study involving 41 CF patients, 26 of whom were chronically colonized with P. aeruginosa (Pa group), and 15 of whom were colonized with S. aureus (Sa group).Two independent radiologists evaluated the HRCT scans of these patients using the modified Bhalla CT scoring system in two different moments. Intraobserver and interobserver reliability was calculated using the intraclass correlation coefficient (ICC). Results: There was good intraobserver and interobserver agreement (ICC > 0.8). Scores were higher in the Pa group than in the Sa group for observer 1 (mean, 13.50 ± 3.90; median, 13.5 vs. mean, 5.00 ± 5.28; median, 3.0) and for observer 2 (mean, 11.96 ± 5.07; median, 12.0 vs. mean, 5.07 ± 5.65; median, 5.0). In addition, HRCT findings, such as bronchiectasis, bronchial wall thickening, mucus plugging, generation of bronchial divisions, and mosaic attenuation/perfusion pattern, were more prevalent in the Pa group. Conclusions: The modified Bhalla CT scoring system was reproducible and reliable for use in the evaluation of HRCT scans, allowing distinctions to be drawn between the two groups of patients under study. The higher scores in the Pa group provided evidence of greater pulmonary impairment in that group.Keywords: Cystic fibrosis; Tomography; Staphylococcus aureus; Pseudomonas aeruginosa. ResumoObjetivo: Comparar achados de TCAR em pacientes com fibrose cística (FC) colonizados cronicamente por Pseudomonas aeruginosa ou Staphylococcus aureus, empregando o escore de Bhalla modificado, e avaliar as confiabilidades intraobservador e interobservador do método. Métodos: Estudo transversal retrospectivo incluindo 41 pacientes portadores de FC, 26 dos quais colonizados cronicamente por P. aeruginosa (grupo Pa) e 15 por S. aureus (grupo Sa). Dois radiologistas analisaram independentemente em duas ocasiões, as imagens de TCAR desses pacientes e aplicaram o escore de Bhalla modificado. As confiabilidades intra e interobservador foram avaliadas segundo o coeficiente de correlação intraclasse (CCI). Resultados: Houve boa concordância intraobservador e interobservador (CCI > 0,8). Os resultados dos escores do grupo Pa foram mais elevados que os do grupo Sa para o observador 1 (média de 13,50 ± 3,90 e mediana de 13,5 vs. média de 5,0 ± 5,28 e mediana de 3,0) e para o observador 2 (média de 11,96 ± 5,07 e mediana de 12,0 vs. média de 5,07 ± 5,65 e mediana de 5,0). Alterações tomográficas, como bronquiectasias, espessamento das paredes brônquicas, formação de tampões mucosos, comprometimento de gerações de divisões brônquicas e padrão de atenuação em mosaico, foram mais prevalentes no grupo colonizado por P. aeruginosa. Conclusões: O escore de Bhalla modificado se mostrou reprodutível e confiável p...

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“…As bronchial atresia can be associated with sequestration, a search for associated other anomalies should be done [18].…”

Section: Discussionmentioning

confidence: 99%

“…Bronchocele can be a common finding in cystic fibrosis i.e. two thirds can have this finding [18].This population is prone to have Allergic Bronchopulmonary Aspergillosis (ABPA ), a fungal sensitization leading to further mucus secretion and damage to underlying airways [19]. ABPA is characterized by high density (70 HU) mucus accumulation hyperattenuated mucus (HAM) in some cases.…”

Section: Discussionmentioning

confidence: 99%

Bronchocele, a common but underrecognized condition: a systematic review

Kakarla

2022

Monaldi Arch Chest Dis

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Bronchocele is an abnormal accumulation of mucus often with associated bronchial dilatation. It can be due to either increased production or impaired drainage of mucus in the airways. Diseases like chronic bronchitis, bronchial asthma, bronchiectasis are characterized by high mucus production and other atypical conditions are bronchorrhea and plastic bronchitis with different physical characteristics and compositions of mucus. Improper drainage can lead to bronchocele formation due to underlying benign, malignant tumours or bronchial stenosis. Allergic bronchopulmonary aspergillosis (ABPA) has a peculiar appearance with high attenuated mucus (HAM) in imaging. Careful evaluation of bronchocele is needed as it can be associated with bronchial obstruction or rare causes like plastic bronchitis. Proper identification, evaluation for the underlying cause is key for not missing the underlying diagnosis and accurate treatment.

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High-resolution computed tomography in cystic fibrosis

Cited by 9 publications

References 12 publications

Pulmonary Disease Assessment in Cystic Fibrosis: Comparison of CT Scoring Systems and Value of Bronchial and Arterial Dimension Measurements

Pulmonary Disease Assessment in Cystic Fibrosis: Comparison of CT Scoring Systems and Value of Bronchial and Arterial Dimension Measurements

Escore tomográfico em pacientes com fibrose cística colonizados por Pseudomonas aeruginosa ou Staphylococcus aureus

Bronchocele, a common but underrecognized condition: a systematic review

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