High resolution functional localization of epileptogenic focus with glutamate and electrical signals detection by ultramicroelectrode arrays

Xiao, Guihua; Xu, Shengwei; Song, Yilin; Dai, Yuchuan; Li, Xinrong; Xie, Jingyu; Wang, Yiding; Yu, Xing

doi:10.1016/j.snb.2020.128137

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…As shown in Figure 7D, the solution-gate FET consists of two metallic contacts (namely the source and drain) and a reference electrode (typically Ag/AgCl) immersed into the electrolyte as the gate A-C) Reproduced with permission. [64] Copyright 2020, Elsevier. D) Schematic illustration of solution-gate FET for the detection of electrical signals of NDs.…”

Section: Transmissible Responsive Systemsmentioning

confidence: 99%

“…For instance, the group of Cai fabricated an ultramicroelectrode array which contained four shanks ( Figure 7 A ) with four tips on each of them (Figure 7B ) for detecting glutamate (Glu) and electrical signals concurrently to locate epilepsy lesions. [ 64 ] 16 electrodes with the diameter of 1 µm were distributed orientationally on the tips (Figure 7C ), with one of them modified with glutamate oxidase enzyme for Glu concentration monitoring while the others for electrical signals detection. Similarly, the group of Cai reported a microelectrode array with 9 channels for synergistic detection of dopamine and electrical signals in the rat model of Parkinson's disease.…”

Section: Advanced Strategies For Tspci Of Ndsmentioning

confidence: 99%

“…B) Zoom-in view of red dashed box in (A), showing four tips on every shank. C) Zoom-in view of blue dashed box in (B), showing electrode with the diameter of 1 μm on every tip.A-C) Reproduced with permission [64]. Copyright 2020, Elsevier.…”

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confidence: 99%

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Advanced Temporally‐Spatially Precise Technologies for On‐Demand Neurological Disorder Intervention

2023

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Temporal‐spatial precision has attracted increasing attention for the clinical intervention of neurological disorders (NDs) to mitigate adverse effects of traditional treatments and achieve point‐of‐care medicine. Inspiring steps forward in this field have been witnessed in recent years, giving the credit to multi‐discipline efforts from neurobiology, bioengineering, chemical materials, artificial intelligence, and so on, exhibiting valuable clinical translation potential. In this review, the latest progress in advanced temporally‐spatially precise clinical intervention is highlighted, including localized parenchyma drug delivery, precise neuromodulation, as well as biological signal detection to trigger closed‐loop control. Their clinical potential in both central and peripheral nervous systems is illustrated meticulously related to typical diseases. The challenges relative to biosafety and scaled production as well as their future perspectives are also discussed in detail. Notably, these intelligent temporally‐spatially precision intervention systems could lead the frontier in the near future, demonstrating significant clinical value to support billions of patients plagued with NDs.

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Section: Transmissible Responsive Systemsmentioning

confidence: 99%

Section: Advanced Strategies For Tspci Of Ndsmentioning

confidence: 99%

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Advanced Temporally‐Spatially Precise Technologies for On‐Demand Neurological Disorder Intervention

2023

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“…Epilepsy is a common neurological disorder, affecting about 50 million people worldwide [1,2]. When the excitatory and inhibitory activities are out of balance, the abnormal discharges of neurons cause paroxysmal brain dysfunction, manifested as limb twitching or abnormal conscious behavior [3].…”

Section: Introductionmentioning

confidence: 99%

Flexible Electrocorticography Electrode Array for Epileptiform Electrical Activity Recording under Glutamate and GABA Modulation on the Primary Somatosensory Cortex of Rats

Song

Xiao

et al. 2020

Micromachines

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Epilepsy is a common neurological disorder. There is still a lack of methods to accurately detect cortical activity and locate lesions. In this work, a flexible electrocorticography (ECoG) electrode array based on polydimethylsiloxane (PDMS)-parylene was fabricated to detect epileptiform activity under glutamate (Glu) and gamma-aminobutyric acid (GABA) modulation on primary somatosensory cortex of rats. The electrode with a thickness of 20 μm has good flexibility to establish reliable contact with the cortex. Fourteen recording sites with a diameter of 60 μm are modified by electroplating platinum black nanoparticles, which effectively improve the performance with lower impedance, obtaining a sensitive sensing interface. The electrode enables real-time capturing changes in neural activity under drug modulation. Under Glu modulation, neuronal populations showed abnormal excitability, manifested as hypsarrhythmia rhythm and continuous or periodic spike wave epileptiform activity, with power increasing significantly. Under GABA modulation, the excitement was inhibited, with amplitude and power reduced to normal. The flexible ECoG electrode array could monitor cortical activity, providing us with an effective tool for further studying epilepsy and locating lesions.

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“…Therefore, this article uses Microelectrode arrays (MEAs) implanted in the rat brain to explore the neuronal level of HU model on the hippocampus learning, memory and other functions. MEAs including silicon electrodes have been shown to be used to collect electrophysiological signals with high signal-to-noise ratio in the hippocampus of rat brain [17]- [19]. The purpose of this study was to detect neuroelectrophysiological signals in the CA1 region of the hippocampus of the long-term and acute HU model rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of Long-Term and Acute Hindlimb Unloading Model on Neuroelectrophysiological Signals of Hippocampal Interneurons and Pyramidal Cells Using Microelectrode Arrays

Wang

Liu

et al. 2020

IEEE Access

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Microgravity is the key environment of weightlessness experienced by all astronauts during spaceflights that cause severe physiological alterations in the human body. The effect of microgravity on the nervous system has not been elucidated. In this study, hindlimb unloading rats were used as the simulated microgravity model, and self-designed novel microelectrode arrays were used as the essential tools. The special arrangement of detection sites and platinum nanoparticles modification made the electrodes have excellent performance at the neuron level. By comparing the changes of the neuroelectrophysiological signals in the CA1 regions of rats in different periods of long-term and shortterm modeling, the following results were obtained. In the long-term model, the firing rates reached a peak after about seven days of modeling, and then kept decreasing till 28 days. The average firing rates and individual single cell firing rates of the acute model rose immediately after modeling. Analysis of power spectral density signals showed that the signals shifted to the low frequency band after both long-term and acute modeling. The neurons in the CA1 were classified into pyramidal cells and interneurons. The continuous observation of neurons under the acute modeling showed that the firing rates and amplitude of pyramidal cells have a greater increase than interneurons. The self-designed novel implantable microelectrode arrays provide an advanced tool for the detection of neurons in hindlimb unloading rats. The hippocampal nerve cells were impaired after modulation, and that pyramidal cells were more susceptible than interneurons.

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High resolution functional localization of epileptogenic focus with glutamate and electrical signals detection by ultramicroelectrode arrays

Cited by 8 publications

References 35 publications

Advanced Temporally‐Spatially Precise Technologies for On‐Demand Neurological Disorder Intervention

Advanced Temporally‐Spatially Precise Technologies for On‐Demand Neurological Disorder Intervention

Flexible Electrocorticography Electrode Array for Epileptiform Electrical Activity Recording under Glutamate and GABA Modulation on the Primary Somatosensory Cortex of Rats

Effects of Long-Term and Acute Hindlimb Unloading Model on Neuroelectrophysiological Signals of Hippocampal Interneurons and Pyramidal Cells Using Microelectrode Arrays

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