High‐resolution mass spectrometry exhalome profiling with a modified direct analysis in real time ion source

Xu, Li; Zhang, Kai; Geng, Xin; Li, Hongli; Chen, David D. Y.

doi:10.1002/rcm.9406

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…Similarly 75 and LTP-MS for the offline analysis of exhaled breath metabolites collected onto filter paper. 76…”

Section: Katz Et Al Used Picosecond Infrared Laser Ms (Pirl-msmentioning

confidence: 99%

“…Other groups have applied SESI‐MS to identify exhaled breath biomarkers relating to conditions such as sleep apnea 73 and cystic fibrosis, 74 further demonstrating the versatility of the technique to study breath biomarkers of different diseases and disorders. Although less commonly utilized for breath analysis, other AIMS techniques are applied in this area including DART‐MS to monitor changes in breath metabolites throughout the day 75 and LTP‐MS for the offline analysis of exhaled breath metabolites collected onto filter paper. 76 …”

Section: Applications Of Aimsmentioning

confidence: 99%

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Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

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The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means of performing rapid analysis of samples in their native state, both in and out of the laboratory. The capacity to eliminate sample preparation and pre‐MS separation techniques, leading to true real‐time analysis, has led to AIMS naturally gaining a broad interest across the scientific community. Since the introduction of the first AIMS techniques in the mid‐2000s, the field has exploded with dozens of novel ion sources, an array of intriguing applications, and an evident growing interest across diverse areas of study. As the field continues to surge forward each year, ambient ionization techniques are increasingly becoming commonplace in laboratories around the world. This annual review provides an overview of AIMS techniques and applications throughout 2022, with a specific focus on some of the major fields of research, including forensic science, disease diagnostics, pharmaceuticals and food sciences. New techniques and methods are introduced, demonstrating the unwavering drive of the analytical community to further advance this exciting field and push the boundaries of what analytical chemistry can achieve.

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“…Similarly 75 and LTP-MS for the offline analysis of exhaled breath metabolites collected onto filter paper. 76…”

Section: Katz Et Al Used Picosecond Infrared Laser Ms (Pirl-msmentioning

confidence: 99%

Section: Applications Of Aimsmentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

View full text Add to dashboard Cite

show abstract

“…Gas chromatography ion mobility spectrometry (IMS), may offer an opportunity for point-of-care use and methodology development to discriminate between environmental and endogenous VOCs [ 233 , 234 ]. Furthermore, secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) and high-resolution mass spectrometry with direct analysis of a real-time ion source also offer real-time detection of the metabolome [ 235 , 236 ]. Developmental steps in detecting instruments were accompanied by new possibilities of data analysis by machine learning and artificial intelligence [ 237 , 238 ].…”

Section: Breathomics—breath Fingerprintingmentioning

confidence: 99%

Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics

et al. 2023

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Cancers, chronic diseases and respiratory infections are major causes of mortality and present diagnostic and therapeutic challenges for health care. There is an unmet medical need for non-invasive, easy-to-use biomarkers for the early diagnosis, phenotyping, predicting and monitoring of the therapeutic responses of these disorders. Exhaled breath sampling is an attractive choice that has gained attention in recent years. Exhaled nitric oxide measurement used as a predictive biomarker of the response to anti-eosinophil therapy in severe asthma has paved the way for other exhaled breath biomarkers. Advances in laser and nanosensor technologies and spectrometry together with widespread use of algorithms and artificial intelligence have facilitated research on volatile organic compounds and artificial olfaction systems to develop new exhaled biomarkers. We aim to provide an overview of the recent advances in and challenges of exhaled biomarker measurements with an emphasis on the applicability of their measurement as a non-invasive, point-of-care diagnostic and monitoring tool.

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“…However, the AANP-TOFMS method took 30 s due to the equilibration time in the Nafion dehumidification process . Proton-transfer reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry (SIFT-MS) utilizing H 3 O + as the reagent ion showed remarkable ability for sensitive detection of VOCs in breath, including HCN profile monitoring. ,,, The LOD of HCN reached 1–2 ppbv within 1 s. ,, With calibration of the reagent ions and their reactions with HCN, PTR-MS, and SIFT-MS can reduce the influence of humidity on the quantification of HCN. ,− …”

mentioning

confidence: 99%

Online Detection of HCN in Humid Exhaled Air by Gas Flow-Assisted Negative Photoionization Mass Spectrometry

et al. 2023

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Hydrogen cyanide (HCN) is a well-known toxic compound in many fields. The trace amount of endogenous HCN in human exhalation has been associated with the presence of Pseudomonas aeruginosa (PA) infection in cystic fibrosis (CF) patients. Online monitoring of HCN profile is promising to screen PA infection rapidly and accurately. In this study, a gas flowassisted negative photoionization (NPI) mass spectrometry method was developed for monitoring the single-exhalation HCN profile. The sensitivity could be optimized by introducing helium to eliminate the humidity influence and reduce the low mass cutoff effect, with improvements of a factor 150 observed. By employing a purging gas procedure and minimizing the length of the sample line, the residual and response time were greatly reduced. The limit of detection (LOD) of 0.3 ppbv and time resolution of 0.5 s were achieved. HCN profiles of exhalations from different volunteers before or after gargling with water were detected to show the performance of the method. All profiles showed a sharp peak and a stable end-tidal plateau, representing the concentration of oral cavity and end-tidal gas, respectively. The HCN concentration based on the plateau of the profile showed better reproducibility and accuracy, which indicates this method has potential application in the detection of PA infection in CF patients.

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High‐resolution mass spectrometry exhalome profiling with a modified direct analysis in real time ion source

Cited by 5 publications

References 52 publications

Applications of ambient ionization mass spectrometry in 2022: An annual review

Applications of ambient ionization mass spectrometry in 2022: An annual review

Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics

Online Detection of HCN in Humid Exhaled Air by Gas Flow-Assisted Negative Photoionization Mass Spectrometry

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