High-resolution scanning surface-plasmon microscopy

Somekh, Michael Geoffrey; Liu, Shugang; Velinov, T.; See, C. W.

doi:10.1364/ao.39.006279

Cited by 73 publications

(44 citation statements)

References 17 publications

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“…The interference term from a uniform sample, assuming a linearly polarised reference beam of uniform amplitude, and linearly polarised light incident in the back focal plane (bfp) is given by (Somekh et al, 2000b):…”

Section: Interferometric Microscopy Methods For Determination Of Locamentioning

confidence: 99%

Surface plasmon microscopy: resolution, sensitivity and crosstalk

Pechprasarn

Somekh

2012

Journal of Microscopy

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SummaryThis paper develops the theoretical framework to understand the capability of the interferometric surface plasmon microscope to quantify sample properties in a confined region. We use rigorous diffraction theory to quantify the ability of the system to measure local properties and eliminate crosstalk from adjacent regions. We argue that the interferometric system in the defocused condition defines the measured point of excitation and reradiation of the surface plasmons; which greatly improves localisation. We also present results for the noninterferometric microscope, which confirm that the interferometric based system can perform quantitative measurements over smaller regions.

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Section: Interferometric Microscopy Methods For Determination Of Locamentioning

confidence: 99%

Surface plasmon microscopy: resolution, sensitivity and crosstalk

Pechprasarn

Somekh

2012

Journal of Microscopy

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“…On the other hand, Zare et al has shown that when the wavelength of excitation light switches from 638 nm to 532 nm, the propagation length on gold-plated surface can be reduced from 8.3 µm to 0.5 µm (in air), without significantly compromising the refractive index sensitivity [128]. Finally, by focusing the laser beam to a narrow line and scanning the laser line across the surface, the lateral resolution can be greatly improved, though it decreases temporal resolution for time-course scanning due to the scanning process [145,146].…”

Section: Spatial Resolution and Image Reconstructionmentioning

confidence: 99%

Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing

Aguirre

Long

et al. 2018

Chemosensors

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Abstract:The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.

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“…Thanks to the development of SPR techniques, some novel SPR-based microscopies have been proposed, such as, SPR enhanced fluorescence microscopy [47,48], surface enhanced Raman microscopy [49], SPR enhanced second harmonic generation microscopy [17,18], surface plasmon enhanced two-photon florescence [50], SPR multi-photon microscopy [51], wide-field SPR microscopy [52], SPR scanning near-field optical microscopy [53,54], far-field optical microscope based on in-plane surface plasmon imaging [55,56], and scanning surface plasmon microscopy SSPM [27,57,58]. Some of these new generation microscopies not only inherit the high sensitivity and sometimes SPR to interface, but also have a higher resolution beyond the diffraction limit of excitation light.…”

Section: Surface Plasmon Microscopymentioning

confidence: 99%