High‐Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis

Wills, Rebecca H.; Tosin, Manuela; O’Connor, Peter B.

doi:10.1002/9781118876015.ch12

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Mass Spectrometry1

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2016

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“…Current mass spectrometry fragmentation techniques include collision induced dissociation, infrared multiphoton dissociation, blackbody radiative dissociation, surface-induced dissociation, electron capture dissociation, and electron transfer dissociation. These techniques can often provide complementary structural information . In addition to natural products chemistry, tandem mass spectrometry is a work horse in small and large biomolecule analysis, including all omics areas.…”

Section: Mass Spectrometrymentioning

confidence: 99%

Structural Analysis of Natural Products

et al. 2016

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Current mass spectrometry, nuclear magnetic resonance spectroscopy, and X-ray diffraction are presented as structure elucidation tools for analytical chemistry of natural products. Discovering new molecular entities combined with dereplication of known organic compounds represent prerequisites for biological assays and for respective applications as pharmaceuticals or molecular markers. Liquid chromatography is briefly addressed with respect to its use in mass spectrometry- and nuclear magnetic resonance-based metabolomics studies.

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Section: Mass Spectrometrymentioning

confidence: 99%