2020
DOI: 10.3389/fonc.2020.597813
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High Response Rate and Prolonged Survival of Unresectable Biliary Tract Cancer Treated With a New Combination Therapy Consisting of Intraarterial Chemotherapy Plus Radiotherapy

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Cited by 4 publications
(8 citation statements)
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“…Median OS survival and post-PSM multivariate Cox regression were compared for RT versus no surgery without RT, illustrating that palliative RT significantly improved survival and prognosis (Tables 4, 5). A recent study showed that combination therapy consisting of intraarterial chemotherapy plus external beam RT might further improve these results (33).…”
Section: Discussionmentioning
confidence: 99%
“…Median OS survival and post-PSM multivariate Cox regression were compared for RT versus no surgery without RT, illustrating that palliative RT significantly improved survival and prognosis (Tables 4, 5). A recent study showed that combination therapy consisting of intraarterial chemotherapy plus external beam RT might further improve these results (33).…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, stent placement with hepatic arterial infusion (HAI) alone or combined with other therapies can be considered. Retrospective studies have shown improved OS when combining HAI with systemic chemotherapy or RT compared with either modality alone 28–31. A large multicenter retrospective study compared outcomes for stent placement with HAI and RFA versus stent alone and demonstrated longer median stent patency and survival times for the combination group versus the control group, without differences in adverse events between the 2 groups 32…”
Section: Methodsmentioning
confidence: 99%
“…Retrospective studies have shown improved OS when combining HAI with systemic chemotherapy or RT compared with either modality alone. [28][29][30][31] A large multicenter retrospective study compared outcomes for stent placement with HAI and RFA versus stent alone and demonstrated longer median stent patency and survival times for the combination group versus the control group, without differences in adverse events between the 2 groups. 32 In summary, treatment of MBO is typically performed using endoscopic or percutaneous drainage, usually with stent placement.…”
Section: Management Of Malignant Biliary Obstruction (Mbo)mentioning
confidence: 99%
“…Figure 1 shows the IAC + RT therapy schedule. The protocol was based on our previous report [19], but the off-label drugs epirubicin and etoposide were excluded, and the irradiation method was adapted to the current mainstream. First, blood flow modification and one-shot IAC of CDDP at 50 mg were performed for angiography.…”
Section: Treatmentmentioning
confidence: 99%
“…High RRs have been reported with intra-arterial chemotherapy (IAC) [13][14][15] and radiation therapy (RT) [16][17][18], but the efficacy of IAC with RT for unresectable BTC has not been established. Recently, our retrospective study noted the high efficacy of the combination therapy regimen of IAC and RT (IAC + RT) (mOS: 15.4 months, mPFS: 14.3 months, and RR: 40.4%) in cases of unresectable BTC [19].…”
Section: Introductionmentioning
confidence: 99%